Clinical trials: Parotid Tumor
Adenocarcinoma, Adenocystic Carcinoma
The Registry of Oncology Outcomes Associated With Testing and Treatment
This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation.
- Conditions
- Adenocarcinoma, Adenocystic Carcinoma, Anal Cancer, Appendix Cancer
- Trial name
- ROOT (NCT04028479)
- Testing
- Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Taproot Health
Nasopharyngeal Neoplasms
Study Using Intensity-modulated Radiation Therapy in Patients With Nasopharynx Cancer to Permit Sparing of Contralateral Parotid Gland Function
One of the side effects of standard radiation therapy for cancer of the nasopharynx is a permanent lessening of normal mouth moisture (saliva).
- Trial name
- NCT00123864
- Testing
- Intensity-modulated radiation therapy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Alberta Health services
Parotid Tumor, Parotid Neoplasms
Trident Landmark as a Safe and Easy Method for Facial Nerve Trunk Identification During Superficial Parotidectomy
The parotid has a close relationship with the extra temporal course of the facial nerve. The study aimed to evaluate the accuracy and safety of trident landmark during superficial parotidectomy in the identification of the facial…
- Conditions
- Parotid Tumor, Parotid Neoplasms, Surgery, Head and Neck Disorder
- Trial name
- NCT04803032
- Testing
- Superficial parotidectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Parotid Neoplasm, Bupivacaine
Clinical Tolerance of an Intraparotid Injection of Bupivacaine, Combined With Dexamethasone, After Parotidectomy for Benign Tumor
There has been a paradigm shift toward less invasive surgical techniques for parotidectomies, primarily to mitigate post-surgical complications.
- Conditions
- Parotid Neoplasm, Bupivacaine, Dexamethasone
- Trial name
- PAROCAINE (NCT07812259)
- Testing
- Intraparotid injection of bupivacaine/ dexamethasone
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Head and Neck Cancer
Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment
Primary Objective: To determine if amifostine in combination with IMRT can mitigate the decrease in production of saliva by the submandibular and sublingual salivary glands in patients with HNSCC. Secondary Objectives: 1.
- Trial name
- NCT00409331
- Testing
- Amifostine, Intensity- Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Parotid Gland Neoplasm
Pattern and Surgical Treatment of Parotid Gland Neoplasms
in these study we analyze pattern of parotid gland neoplasms according to histopathological types, most common type clinical presentation and type of surgical treatment(superficial parotidectomy or total parotidectomy radical…
- Trial name
- NCT05505318
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Squamous Cell Carcinoma of Head and Neck (SCCHN), Metastatic Colorectal Cancer
Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy
This was an open-label, phase Ib, multicenter clinical trial to determine the MTD/RDE of the orally administered c-MET inhibitor INC280 in combination with cetuximab.
- Trial name
- NCT02205398
- Testing
- INC280, cetuximab
- Where
- 15 sites in United States, Belgium and 5 more
- Volunteers
- 13 people
- Sponsor
- Novartis Pharmaceuticals
Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
Background: Radiation can cause the parotid salivary glands to make less saliva (dry mouth). This can cause problems like infections and tooth decay. Researchers hope a new drug can help people with dry mouth caused by radiation.
- Conditions
- Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
- Trial name
- NCT02446249
- Testing
- AAV2hAQP1
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MeiraGTx, LLC
Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary
Optical Detection of Peripheral Nerve Bundles During Surgery
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue.
- Conditions
- Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary, Malignant Lymphoma of Lymph Nodes of the Cervix, Carcinoma of Parotid Gland
- Trial name
- NerveSpect (NCT01731379)
- Testing
- Surgical resection
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Philips Healthcare
Oropharynx Cancer, Head and Neck Cancer
Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia
Radiation-induced xerostomia (dry mouth) is one of the most common and severe toxicities experienced by patients undergoing radiation treatment for head and neck cancer.
- Conditions
- Oropharynx Cancer, Head and Neck Cancer, Xerostomia
- Trial name
- NCT06276946
- Testing
- standard radiotherapy, experimental radiotherapy
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer
Using Intensity-Modulated Radiation Therapy to Permit Sparing of Parotid Gland Function
Radiotherapy is the primary treatment modality or an important adjunct treatment for many patients with H\&N carcinoma. Local control is directly related to dose and to the technical accuracy with which the dose is delivered to…
- Trial name
- NCT00137475
- Testing
- Intensity-Modulated Radiation Therapy
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- AHS Cancer Control Alberta
Head and Neck Cancer
Parotid-gland Stem-cell Sparing Intensity-modulated Radiotherapy
Rationale: Radiation-induced parotid gland dysfunction, often leading to xerostomia is the most-frequently occurring side-effect with a major impact on patient-reported quality of life after radiotherapy for head and neck cancer…
- Trial name
- SCS-IMRT (NCT01955239)
- Testing
- Intensity-modulated Radiotherapy
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- University Medical Center Groningen
Radiation Injuries, Xerostomia
Structure and Functional Status of Parotid Glands Exposed to Therapeutic Irradiation
Therapeutic irradiation to the head and neck for cancer damages salivary glands present in the radiation field. Despite long recognition of radiation-induced salivary hypofunction, and the associated oral morbidities, the…
- Trial name
- NCT00001523
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Parotid Neoplasms, Post-operative Complications
Swedish National Parotidectomy Study (SNaPs): Drainless Versus Standard Surgery
The purpose of this study The purpose of this study is to find out if it is safe to perform surgery on the parotid gland (the large salivary gland in front of the ear) without using a wound drain.
- Conditions
- Parotid Neoplasms, Post-operative Complications, Seroma as Procedural Complication
- Trial name
- SNaPs (NCT07620184)
- Testing
- Active wound drainage (Standard of Care), Omission of active wound drain
- Where
- 3 sites in Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University Hospital
Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm
Customized 3D Printed Oral Stents During Head and Neck Radiotherapy
This clinical trial studies the effect of customized 3 dimensional (3D) printed oral tents on patients with head and neck cancer who are receiving radiotherapy.
- Conditions
- Head and Neck Carcinoma, Malignant Parotid Gland Neoplasm, Maxillary Sinus Carcinoma, Nasal Cavity Carcinoma
- Trial name
- NCT04870762
- Testing
- Best Practice, Medical Device Usage and Evaluation
- Where
- 7 sites in United States
- Volunteers
- 88 people
- Sponsor
- M.D. Anderson Cancer Center
Parotid Tumor
FArial NErf MRI in the Preoperative Assessment of PArotide Tumors
1. st visit: Inclusion, 3Tesla injected parotid MRI performed as part of routine care for characterization, to which two specific high resolution sequences will be added.
- Trial name
- NEFAPA (NCT04613349)
- Testing
- MRI
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Nasopharyngeal Carcinoma, Radiation-induced Xerostomia
Impact on Xerostomia for Nasopharyngeal Carcinoma Patients Treated With or Without Superficial Parotid Lobe-sparing Intensity-modulated Radiotherapy
This is a prospective phase II clinical randomized controlled study, the purpose of this study is to assess whether superficial parotid lobe-sparing intensity-modulated radiotherapy (SPLS-IMRT) can decrease the incidence of…
- Trial name
- NCT05020067
- Testing
- superficial parotid lobe-sparing intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Xerostomia, Radiation-induced Parotid Damage,Predictivevalue,Head and Neck Cancer
Prospective Study on Monitoring Parotid Gland Injury After Radiotherapy for Head and Neck Tumors Using Multimodal Radiomics
Exploring a non-invasive and objective method for ultra early quantitative assessment of radiation-induced parotid gland injury.
- Trial name
- NCT06792526
- Testing
- IVIM Imaging MRF Imaging
- Volunteers
- 20 people
- Sponsor
- Hainan People's Hospital
Advanced Cancer, Anal Carcinoma
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
In this study, participants with multiple types of advanced (unresectable and/or metastatic) solid tumors who have progressed on standard of care therapy will be treated with pembrolizumab (MK-3475).
- Conditions
- Advanced Cancer, Anal Carcinoma, Anal Cancer, Biliary Cancer
- Trial name
- NCT02628067
- Testing
- pembrolizumab
- Volunteers
- 1,609 people
- Sponsor
- Merck Sharp & Dohme LLC
Radiofrequency Ablation
Radiofrequency Ablation for Warthin's Tumor
This study is a safety and feasibility study to determine if ultrasound guided radiofrequency ablation of parotid Warthin's tumor under local anesthesia is a safe and effective procedure compared to Parotidectomy while using less…
- Trial name
- NCT05078541
- Testing
- Ultrasound-guided Radiofrequency Ablation of Parotid Warthin's Tumor
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong