Clinical trials: Partial Nephrectomy
Kidney Tumors Treated With Minimally Invasive Surgery
Partial Nephrectomy in Low Pressure
The main objective is to prospectively assess the impact of low insufflation pressure using AirSeal system (7mm Hg) during RAPN on post-operative patient pain (main location and intensity), 24 hours after surgery.
- Trial name
- P-NeLoP (NCT05404685)
- Testing
- Low insufflation pressure (7mm Hg) for Robotic Assisted Partial Nephrectomy, Standard insufflation pressure (12mm Hg) for Robotic Assisted Partial Nephrectomy
- Where
- 15 sites in France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Bordeaux
Kidney Injury
Intraoperative Near Infrared Spectroscopy of Kidney for Prediction of Acute and Sub-acute Kidney Injury in Partial Nephrectomy
Intra-operative NIRS measurements of kidney during partial nephrectomy, after reperfusion, for monitoring ischemia and prediction of postoperative renal dysfunction.
- Trial name
- NCT05146947
- Testing
- near infrared spectroscopy
- Volunteers
- 90 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Kidney Cancer, Long-term Effects Secondary to Cancer Therapy in Adults
Warm Ischemia or Cold Ischemia During Surgery in Treating Patients With Stage I Kidney Cancer
RATIONALE: Warm ischemia is the clamping of blood vessels without cooling the kidney. Cold ischemia is the clamping of blood vessels with kidney cooling.
- Conditions
- Kidney Cancer, Long-term Effects Secondary to Cancer Therapy in Adults, Perioperative/Postoperative Complications, Urinary Complications
- Trial name
- NCT00743236
- Testing
- cold ischemia procedure, warm ischemia procedure
- Where
- 8 sites in United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Renal Cancer, Renal Neoplasm
LPN in Patients With High-complex Renal Tumors
The study aims to investigate the rationale for LPN in patients with high-complexity renal tumors in terms of oncologic and functional outcomes.
- Conditions
- Renal Cancer, Renal Neoplasm, Renal Cell Carcinoma, Surgery
- Trial name
- NCT04933604
- Testing
- laparoscopic partial nephrectomy, Laparoscopic radical nephrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Samsun Liv Hospital
Renal Impairment, Kidney Diseases
Renal Hypothermia During Partial Nephrectomy
The Objective is to determine if renal hypothermia during open partial nephrectomy results in improved post-operative renal function compared to warm ischemia.
- Conditions
- Renal Impairment, Kidney Diseases, Urologic Diseases, Cancer
- Trial name
- NCT01529658
- Testing
- Renal hypothermia
- Where
- 6 sites in Canada
- Volunteers
- 184 people
- Sponsor
- Ottawa Hospital Research Institute
Renal Tumors
Imaging-Guided Classification for Endophytic Renal Tumors: PN Strategies & Outcomes
Study Title: Imaging-Guided Classification \& Surgical Outcomes in Endophytic Renal Tumors Study Goal: This observational study investigates whether an imaging-guided classification system improves partial nephrectomy (PN)…
- Trial name
- NCT06954571
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Tianjin Medical University Second Hospital
Benign Renal Tumors, Malignant Renal Tumors
First-in-Human Safety Study Of Laser Tissue Welding For Surtureless Laparoscopic Partial Nephrectomy
The objective of this pilot study will be to obtain a clinical safety and efficacy endpoint profile of laser tissue welding therapy for sealing the resected kidney surface after laparoscopic partial nephrectomy required for…
- Trial name
- LTW-KIDNEY (NCT02061605)
- Testing
- Laser Tissue Welding Device
- Where
- United States
- Sponsor
- Laser Tissue Welding, Inc.
Renal Cancer
Open vs Robotic Assisted Partial Nephrectomy
To demonstrate that Robotic-Assisted partial nephrectomy is superior to Open partial nephrectomy in reducing the number of 30 day post-operative complications (Clavien-Dindo Type I-V) for patients with intermediate to high…
- Trial name
- OpeRa (NCT03849820)
- Testing
- Robotic-assisted partial nephrectomy, Open partial nephrectomy
- Where
- 12 sites in Germany
- Volunteers
- 247 people
- Sponsor
- Intuitive Surgical
Partial Nephrectomy, Renal Cell Carcinoma
Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy
Many patients who are candidates for nephron-sparing surgery, partial nephrectomy is now the standard treatment with a surgical, small, clinical T1 tumor (<7 cm).
- Trial name
- NCT01720693
- Testing
- Hypoperfusion of renal artery
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University Health Network, Toronto
Renal Tumors Less Than 4 cm
Study to Evaluate the Efficacy of Percutaneous Cryoablation for Renal Tumours < 4cm in Patients Who Are Not Candidates for Partial Nephrectomy
The main objective is to evaluate the oncologic efficacy of percutaneous cryoablation of renal tumors smaller than 4 cm in patients with renal cancer that cannot be offered a partial nephrectomy.
- Trial name
- CRYOREIN (NCT01471002)
- Testing
- Galil Medical patented 17G Cryoablation Needles
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Kidney Cancer, Renal Cell Carcinoma
A Novel Haemostatic Agent for Robotic Partial Nephrectomy
Kidney cancer is one of only a few cancers with an increasing incidence over the past two decades. Renal cell carcinoma (RCC) accounts for over 85% of all kidney tumours, which makes up 2-3% of all adult malignancies.
- Trial name
- PuraBond (NCT07284953)
- Testing
- PuraBond
- Where
- United Kingdom
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Renal Masses
Comparison of OpeN VErsus RoboTic Partial Nephrectomy
A prospective randomized controlled feasibility trial for patients undergoing partial nephrectomy for T1 renal masses at Princess Margaret. Participants will be randomized receive either open or robotic partial nephrectomy.
- Trial name
- CONVERT (NCT04011891)
- Testing
- Robotic Partial Nephrectomy, Open Partial Nephrectomy
- Where
- Canada
- Sponsor
- University Health Network, Toronto
Nephrectomy
Bipolar Coagulation Versus Suture Renorrhaphy in Laparoscopic Partial Nephrectomy
To compare between bipolar coagulation of tumor bed in laparoscopic partial nephrectomy versus suture renorrhaphy
- Trial name
- NCT05498246
- Testing
- laparoscopic partial nephrectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Renal Cancer
Zero-ischemia Robot-assisted Partial Nephrectomy Using Near-infrared Fluorescence
Patients with renal cancer are commonly treated by robot-assisted partial nephrectomy. Renal artery clamping is commonly required inducing kidney ischemia during surgery. It impacts parenchymal and renal function.
- Trial name
- EMERALD (NCT03679572)
- Testing
- Robot assisted partial nephrectomy super-selective clamping, Robot assisted partial nephrectomy with renal artery clamping
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Nephrectomy, Kidney Cancer
Nephrotoxicity Associated to Parenchymal Clamping During Partial Nephrectomy Using a Microdialysis Technique
Surgery plays a central role in kidney cancer management being the only therapy that offers the possibility of healing the patients.
- Conditions
- Nephrectomy, Kidney Cancer, Microdialysis
- Trial name
- NECPAR (NCT02511275)
- Testing
- Renal microdialysis
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Renal Tumor
A Comparative Study Between Open and Robotic Partial Nephrectomy in Treatment of High Complex Renal Tumors.
To compare safety and efficacy between open and robotic partial nephrectomy in treatment of organ confined complex renal tumors (R.E.N.A.L score more than 7) as regarding surgical results, morbidity, clinical as well as…
- Trial name
- NCT04537247
- Testing
- partial nephrectomy for complex renal tumor
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Renal Cell Carcinoma
Oncological and Functional Outcomes of Laparoscopic Partial Nephrectomy in Renal Cell Carcinoma Stages T1 Versus T2a: Prospective Comparative Study.
RCC represents around 3% of all cancers, with the highest incidence occurring in Western countries . Within the several RCC risk factors identified, smoking, obesity, and hypertension are most strongly associated with RCC .
- Trial name
- NCT05486871
- Testing
- laparoscopic partial nephrectomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Kidney Neoplasms
Zero Ischemia Laparoscopic Radio Frequency/Microwave Ablation Assisted Enucleation of Renal Cell Carcinoma With T1 Stage
Zero ischemia laparoscopic radio frequency ablation assisted tumor enucleation has been proved to enable tumor excision with relatively better renal function preservation comparing with conventional laparoscopic partial…
- Trial name
- NCT02734329
- Testing
- conventional laparoscopic partial nephrectomy, zero ischemia laparoscopic RFA/MVA assisted tumor enucleation (TE)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- RenJi Hospital
RCC, Renal Cell Cancer, Partial Nephrectomy
Prospective Study on the Safety and Efficacy of Robot-Assisted Laparoscopic Partial Nephrectomy With Renal Artery Off-Clamp in the Treatment of cT1 Renal Tumors
Renal tumors are common urological cancers, with over 430,000 new cases and more than 170,000 deaths globally in 2020. In China, renal cancer ranks third among urological malignancies, with an increasing incidence.
- Trial name
- NCT06908902
- Testing
- partial nephrectomy with main or branch renal artery clamping, partial nephrectomy with zero renal artery clamping
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Renal Cell Carcinoma (RCC)
Computed Tomography Radiomics-Derived Nomogram for Predicting Early Renal Function Decline After Partial Nephrectomy in Renal Cell Carcinoma: A Multicenter Development/Validation Study
The goal of this observational study is to explore the relationship between CT-based radiomics and postoperative renal function changes in patients with localized renal cell carcinoma (RCC) undergoing partial nephrectomy (PN).
- Trial name
- NCT07117786
- Testing
- CT Contrast, Computed Tomography
- Volunteers
- 1,437 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University