Clinical trials: Partial Pancreatectomy
Pancreatectomy, Total Pancreatectomy
Hybrid Closed-Loop Insulin Delivery After Pancreatectomy
Individuals with diabetes secondary to pancreatectomy experience impaired quality of life, partly due to the challenges of managing highly variable blood glucose levels.
- Conditions
- Pancreatectomy, Total Pancreatectomy, Partial Pancreatectomy
- Trial name
- HCL PP (NCT07430293)
- Testing
- MiniMed 780 associated with Simplera
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Sud Francilien
Pancreatectomy; Hyperglycemia, Diabete Mellitus
Glucose Metabolism After Partial Pancreatectomy
This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.
- Trial name
- NCT04409171
- Testing
- oral glucose tolerance test
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diabetes Mellitus
Study on Pancreatic Islets in Patients Undergoing (Partial) Pancreatectomy (PRECISE)
The study investigates the mechanisms underlying the pathogenesis of diabetes by examining structural and functional properties of islets of Langerhans in pancreas specimen from patients undergoing (partial) pancreatectomy.
- Trial name
- PRECISE (NCT06150690)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- German Diabetes Center
Diabetes Mellitus Type 2, Pancreatectomy
Clinical, Oncological and Metabolic Effects of Pancreatic Mass Loss After Partial, Near-total and Total Pancreatectomy in Patients With Preoperative Diabetes Mellitus
This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time.
- Conditions
- Diabetes Mellitus Type 2, Pancreatectomy, Pancreatic Neoplasms
- Trial name
- DCP-DM (NCT07607912)
- Volunteers
- 408 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Whipple Procedures, Pancreatic Cancer
Energy Expenditure and Nutrition After Pancreatic Surgery
This prospective observational cohort study examines the energy requirements and nutritional care of patients undergoing total or partial pancreatectomy for pancreatic tumors.
- Conditions
- Whipple Procedures, Pancreatic Cancer, Pancreaticoduodenectomy, Pancreatic Neoplasms
- Trial name
- NUTRI-PD (NCT07703813)
- Testing
- Pancreatectomy, Indirect calorimetry
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Evangelismos Hospital
Pancreatogenic Diabetes Mellitus
Prediction of Pancreatogenic Diabetes After Partial Resection of the Pancreas
The primary aim of the study is to identify clinical, laboratory, imaging, and pathohistological risk factors for the development of pancreatogenic diabetes after partial resection of the pancreas (PRP) and, based on these, to…
- Trial name
- NCT07665710
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Type 1 Diabetes, Pancreatectomy; Hyperglycemia
Collection of Human Liver Biopsy and Whole Blood Samples From T1DM, TP or PP Patients for Potential Use for Insulin Producing Cells in Future Clinical Studies
In this study, liver samples will be collected, processed and stored in a specialized, clinical grade, cell bank for potential future clinical use.
- Trial name
- NCT04038931
- Testing
- Liver biopsy collection
- Volunteers
- 20 people
- Sponsor
- Orgenesis Ltd.
Tumor of Exocrine Pancreas
Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors
Most resectable tumors arising in the body or tail of the pancreas are malignancies or premalignancies which are surgically treated with distal pancreatectomy in combination with splenectomy.
- Trial name
- NCT01412684
- Testing
- Distal pancreatectomy with partial splenectomy
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Pancreas Neoplasm
Postoperative Outcomes After Partial Duodenopancreatectomy Versus Total Pancreatectomy
The goal of this observational study is to compare short-term outcomes after partial pancreatoduodenectomy and total pancreatectomy in adults undergoing elective surgery for pancreatic or periampullary neoplasms in Switzerland.
- Trial name
- NCT07831694
- Volunteers
- 3,602 people
- Sponsor
- Cantonal Hospital of St. Gallen
Pancreatic Cancer, Pancreatic Adenocarcinoma
GI-06: The Impact of Perioperative Hydrocortisone on Patients Undergoing Partial Pancreatectomy
This is a single-site, randomized, controlled treatment trial evaluating perioperative steroid hydrocortisone use in patients undergoing pancreatic resection (partial pancreatectomy).
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Duodenal Cancer, Distal Cholangiocarcinoma
- Trial name
- NCT07796997
- Testing
- Hydrocortisone, Pancreatic resection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Impaired Glucose Tolerance
The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
The purpose of this study is to examine changes in sugar metabolism that may occur in subjects who have previously had part of their pancreas removed due to a benign lesion.
- Trial name
- Pilot OGTT (NCT00841867)
- Testing
- All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pancreatectomy, Diabetes Mellitus Type 2
Clinical, Oncologic, and Metabolic Effects of Pancreatic Mass Loss After Pancreatectomy in Non-Diabetic Patients
This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time.
- Conditions
- Pancreatectomy, Diabetes Mellitus Type 2, Pancreatic Neoplasms
- Trial name
- DCP-NDM (NCT07608055)
- Where
- Italy
- Volunteers
- 579 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreatic Tumor, Benign, Pancreatic Neoplasms
Laser Tissue Welding - Distal Pancreatectomy Sealing Study
The laser tissue welding device is intended for use in patients requiring sealing of the pancreas after partial pancreatectomy, and including those patients who are fully heparinized or have hemodilutional coagulation failure.
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Neoplasms, Pancreatic Adenocarcinoma, Pancreatic Pseudocyst
- Trial name
- LTW (NCT03147768)
- Testing
- Distal Pancreatectomy Sealing Using LTW
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Laser Tissue Welding, Inc.
SIBO, Pancreatic Insufficiency
Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy
Pancreatic exocrine insufficiency (PEI) results from reduced pancreatic enzyme secretion, leading to malabsorption, malnutrition, and impaired quality of life.
- Conditions
- SIBO, Pancreatic Insufficiency, Chronic Pancreatitis, Pancreatic Surgey
- Trial name
- DCP-PCT-EPI (NCT07479238)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Partial Pancreatectomy Due to Benign Pancreatic Neoplasm
Effect of Islet Autotransplantation Compared to Oral Antidiabetic Drug.
Effects of autologous islet transplantation were compared to those of oral anti-diabetic drugs after distal pancreatectomy. The primary interest is a insulin-secretory function after the surgery in two intervention groups.
- Trial name
- NCT01922492
- Testing
- Autologous islet transplantation, Oral anti-diabetic drugs
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Seoul National University Hospital