Clinical trials: Patency Rate
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Effects of Repeat Doses of Fluticasone Furoate and GW642444M Combination in Healthy Subjects and in Subjects With Severe Impairment.
This study will assess the saftey of giving fluticasone furoate 200mcg/GW642444M 25mcg once daily for 7 days to patients with severe renal imparement.
- Trial name
- NCT01266980
- Testing
- Inhaled FF/ GW642444M (200/25mcg)
- Where
- Czechia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Phase I Safety, Pharmacokinetics and Bioavailability Study Comparing Rate and Extent of Absorption of Two Different Forms of Tafamidis (PF-6291826)
2 different formulations and 4 different single doses of tafamidis will be compared. All subjects will receive both formulations and 3 different doses. Subjects will be fasted before taking the drug.
- Trial name
- NCT03662191
- Testing
- Tafamidis
- Where
- Belgium
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain
Investigation of Rate + Extent of Excretion of Radioactivity in Urine +Faeces After Oral Administration of [14C]AZD2066
The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD2066 in healthy male volunteers.
- Trial name
- NCT00829088
- Testing
- AZD2066
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
A Study to Assess the Effects of Fluticasone Furoate and GW642444M Combination in Healthy Subjects and in Subjects With Mild, Moderate or Severe Hepatic Impairment.
In relation to their severity, hepatic diseases can significantly modify drug absorption and disposition and consequently can interfere with drug efficacy and/or produce toxicity.
- Trial name
- NCT01266941
- Testing
- Inhaled FF 200mcg/GW642444M 25mcg
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Side Effect of Drug
Evaluation of Safety, Rate and Extent of Absorption of Psilocin Mucate
Psilocin is the active metabolite of psilocybin a natural material found in several types of fungi. The bioavailability of psilocybin, the prodrug of psilocin, has been reported to be over 60%.
- Trial name
- Psilocin-1 (NCT06035900)
- Testing
- Psilocin
- Where
- Jordan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lobe Sciences Ltd.
Healthy Volunteers
A Study to Evaluate the Bioavailability of Risankizumab Following Subcutaneous Dosing in Healthy Male Participants
The objective of this study is to evaluate the bioavailability, safety and tolerability of risankizumab following subcutaneous injections in healthy male participants.
- Trial name
- NCT05283694
- Testing
- risankizumab
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy, Bioavailability
Comparative Bioavailability Study of an Immediate Release and Controlled Release Oral Formulations of Huperzine A
The purpose of this study is to develop oral controlled release formulation of Huperzine A that will provide optimal pharmacokinetic profile of the drug enhancing safety and compliance, as possible cure to neurodegenerative…
- Trial name
- NCT01136551
- Testing
- Huperzine A
- Where
- Israel
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Influenza, Human
A Study to Determine the Safety and Attack Rate of the Seasonal Flu in Healthy Volunteers
This is a non-controlled, open-label, single-centre, dose-escalation study to determine the safety, infectivity and immunology of the potential novel influenza virus H3N2 challenge strain.
- Trial name
- NCT04372719
- Testing
- H3N2
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SGS Life Sciences, a division of SGS Belgium NV
Healthy
A Study With an Open-Label Active Control to Evaluate the Potential of Nestorone® to Delay Cardiac Repolarization in Healthy Female Volunteers
The purpose of the study is to evaluate the effect of Nestorone (NES) administered as an bolus injection on the corrected QT interval using Fridericia's formula (QTcF).
- Trial name
- NCT02236026
- Testing
- Supratherapuetic dose of Nestorone, Moxifloxacin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Population Council
Healthy, Bioequivalence Study
Bioequivalence Study of DelanzoᵀᴹDR 60mg (Dexlansoprazole) Capsule With Dexilant® 60mg (Dexlansoprazole) Capsule in Healthy Pakistani Subjects.
Single oral dose of study drug in two period(s) separated by a washout period of seven (07) days. Blood samples will be taken up to 24.0 hours post-dose.
- Trial name
- BABE (NCT04877834)
- Testing
- Dexlansoprazole
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Karachi
Healthy
A Study To Determine If Coadministration Of Tamoxifen Alters The Extent Or Rate Of Palbociclib (PD-0332991) Absorption Or Elimination In Healthy Male Volunteers
A single 125 mg oral dose of the investigational compound PD-0332991 will be administered alone and after steady-state dosing of tamoxifen to determine if coadministration of tamoxifen alters the plasma pharmacokinetics of…
- Trial name
- NCT01821066
- Testing
- PD-0332991 alone, Tamoxifen 60 mg, Tamoxifen 20 mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Pfizer
Erythema
Affect of Dose Rate on UVR Induced Skin Erythema
Purpose of study: Evaluation of the affect of dose rate on UVR induced skin erythema. Study design: A single-center, prospective, randomized, crossover, open study.
- Trial name
- NCT00785187
- Testing
- exposure to UVB radiation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Goldenhersh, Michael, M.D.
Pain, Postoperative, Apical Periodontitis
FE in Anterior Teeth
The purpose of this study is to determine whether enlarging the apical foramen causes postoperative pain in maxillary anterior teeth with apical periodontitis.
- Trial name
- NCT03527602
- Testing
- Foraminal enlargement
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Metabolic Processes
A Study to Assess the Systemic Pharmacokinetics, Metabolism and Excretion Routes of YM178 in Man, After Administration of Radio-labeled YM178
The study aims to assess the routes and the extent of metabolism and excretion of YM178 after a single dose of 14C-radiolabeled YM178 administered as a drinking solution in healthy male volunteers.
- Trial name
- NCT01651312
- Testing
- 14C-labeled YM178
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Europe B.V.
Pneumothorax, Pleural Effusion
Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data
Background: The Pleura is a double-layered membrane that surrounds the lungs. Pathological processes that involve the Pleura are called "Pleural diseases".
- Trial name
- NCT04418804
- Testing
- Chest ultrasound
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Israel Aharoni
Glomerular Filtration Rate
Evaluation of Protein Loading on Measurement of Renal Reserve
The goal of this clinical trial is to evaluate the effect of protein loading on the measurement of renal reserve using the MediBeacon Transdermal glomerular filtration rate (tGFR) system.
- Trial name
- NCT07335614
- Testing
- Lumitrace, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Reproductive Techniques, Assisted, DNA Methylation
First Live Birth Rate With eSET After Preimplantation Methylome Screening (PIMS) Versus Conventional In-vitro Fertilization
To determine whether using DNA methylome to select embryos can increase the live birth rate.
- Trial name
- NCT05442125
- Testing
- Using DNA methylome to select embryos, Using morphologic score to select embryos
- Where
- 28 sites in China, Thailand
- Volunteers
- 1,146 people, healthy volunteers welcome
- Sponsor
- Shandong University
Pain
Investigation of Rate+Extent of Excretion of Radioactivity in Urine+Faeces After Oral Administration of [14C]AZD1386
The aim of this study is to get information about absorption, distribution, metabolism and excretion as well as the tolerability and safety of AZD1386 in healthy male volunteers.
- Trial name
- NCT00832169
- Testing
- AZD1386
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Acute Aortic Dissection
Triple-branch Stent Graft Placement for the Treatment of Acute DeBakey I Aortic Dissection
The purpose of this study is to evaluate triple-branched stent placement in the treatment of acute DeBakey I aortic dissection . The investigators design a prospective, single-center, open-label, non-controlled clinical trial.
- Trial name
- TBSGPT (NCT02732340)
- Testing
- triple-branched stent graft
- Where
- China
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
The Apparatus for Processing the Tubular Graft Modification Will be Designed and Evaluated., The On-site Capturing of the Endothelial (Progenitor) Cells by Peptide-mediated Selective Adhesion in Vitro and in Vivo Will Also be Elucidated.
Endothelialized ePTFE Graft by Nanobiotechnology
The replacement of autologous blood vessels by artificial grafts is urgently needed in clinical applications. Expanded polytetrafluoroethylene (ePTFE) grafts are the most clinically used artificial blood vessels because of its…
- Conditions
- The Apparatus for Processing the Tubular Graft Modification Will be Designed and Evaluated., The On-site Capturing of the Endothelial (Progenitor) Cells by Peptide-mediated Selective Adhesion in Vitro and in Vivo Will Also be Elucidated., The Patency Rate of ITRI-made Artificial Blood Vessels Will be Evaluated by the Porcine Animal Model.
- Trial name
- NCT02002104
- Where
- Taiwan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital