Clinical trials: Pathogenesis
Hepatitis C, Infection Transmission, Maternal-Fetal
The Pathogenesis of Hepatitis C Virus Vertical Transmission
To evaluate for the presence of HCV Core protein, HCV RNA and SPP in the placenta and fetal membranes using paraffin-embedded sections and post-delivery specimens respectively.
- Trial name
- NCT01921400
- Where
- 2 sites in United States, Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Polycystic Ovary Syndrome
The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.
Polycystic ovary syndrome (PCOS) has a significant impact on women's health, but its pathogenesis is not yet clear. Dysbiosis of gut microbiota may play a role in the pathological change of PCOS.
- Trial name
- NCT03843736
- Testing
- Lifestyle intervention, Probiotic Agent, Oral contraceptive
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hyperparathyroidism, Chronic Kidney Disease
Sevelamer and Secondary Hyperparathyroidism in Chronic Kidney Disease
The hypothesis underlying this study is that phosphate interferes with PTH-mediated calcium reabsorption in the distal nephron and thereby necessitates supranormal [PTH]to maintain normocalcemia in chronic kidney disease.
- Trial name
- NCT01191762
- Testing
- sevelamer carbonate
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kenneth R. Phelps, M.D.
Healthy
Molecular Mechanism of Neutrophil Necroptosis and Its Roles in RA Pathogenesis
Neutrophils play a central role in innate immunity and are rapidly recruited to sites of infection and injury. Neutrophil apoptosis and necroptosis are essential for the inflammatory.This study is designed to investigate the…
- Trial name
- MMNNIRP (NCT02385331)
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Keratitis; Infectious Disease (Manifestation)
Pseudomonal Type Three Secretion System and Contact Lens Associated Microbial Keratitis
Microbial infection of the cornea, also known as microbial keratitis, causes severe corneal inflammation that could result in permanent visual loss.
- Trial name
- NCT01925846
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Periodontitis
IL29 and IL28B Variants Associated With Periodontal Disease Pathogenesis
A maximum of 220 subjects with a minimum of 25 years will be recruited and examined for this 1-7 visit, up to 35 days research study: Subjects will be genotyped to identify variants of the interleukin-29 (IL29) and…
- Trial name
- NCT02710903
- Testing
- Stent-induced biofilm overgrowth
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mechanism, Marker Screening
Proteomics/Modifier Based on Mass Spectrometry Reveals the Pathogenesis of Eclampsia During Pregnancy and the Screening of Disease Markers
Pregnancy-induced hypertension is a unique abnormal blood pressure disease in women during pregnancy, including eclampsia, preeclampsia, pregnancy-induced hypertension, chronic hypertension and so on.
- Trial name
- NCT04833881
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Heilongjiang University of Chinese Medicine
Myositis, Dermatomyositis
Environmental Risk Factors for the Anti-synthetase Syndrome
Background: Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors.
- Conditions
- Myositis, Dermatomyositis, Polymyositis, Juvenile Dermatomyositis
- Trial name
- NCT01276470
- Where
- 8 sites in United States
- Volunteers
- 580 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture
Hypothesis: The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high…
- Trial name
- PCOSNTS (NCT00484705)
- Testing
- Electroacupuncture, Physical exercise, Untreated control
- Where
- Sweden
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Periodontitis, Gingivitis
Endoplasmic Reticulum Stress Response in Periodontal Disease
Periodontal disease causes inflammation and damage to the tissues that support the teeth. This study looks at whether stress inside gum cells contributes to this damage.
- Trial name
- NCT07751419
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Inonu University
HIV Infections
The Role of Naive T-Cells in HIV Pathogenesis
While HIV mainly infects mature T-cells it can also infect newly produced (or naïve) T-cells. These infected naïve T cells may then act a viral reservoir even in patients with undetectable viral loads.
- Trial name
- NCT00206531
- Where
- Australia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Cancer Cachexia
Effect of Gene Polymorphisms on the Pathogenesis of Cancer Cachexia
Cachexia not only directly increases the morbidity and mortality, it also aggravates the side effects of chemotherapy and reduces the overall quality of life that is often considered the major and direct cause of morbidity of a…
- Trial name
- NCT04131478
- Testing
- Pharmacogenetic testing
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Asthma
Viral Inception of Asthma: Prospective Study From Infancy to School-age
The purpose of this study is to study prospectively the early clinical and immunological events in children susceptible to rhinovirus induced early wheezing (i.e., recently found highest risk factor for recurrent wheezing/asthma)…
- Trial name
- VINKU2 (NCT00731575)
- Testing
- prednisolone
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Turku
Psoriasis Vulgaris
Correlation Between Vaspin Gene Polymorphism and Serum Vaspin Levels in Psoriasis Vulgaris
Psoriasis is a common immune-mediated inflammatory skin disease affecting at least 100 million individuals worldwide. In Egypt, the prevalence of psoriasis ranges between 0.19% and 3% of the Egyptian people.
- Trial name
- NCT07320872
- Testing
- vaspin gene polymorphism
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Polymorphism (Genetics), Endometriosis
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population
Endometriosis, defined as the presence of endometrial tissue outside the uterine cavity, affects 6-10% of the general population of women in childbearing age. The pathogenesis of the disease is unknown.
- Trial name
- NCT02388854
- Testing
- SNPs analysis with Sanger sequencing
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Dry Eye, Fibromyalgia
The Pathogenesis of Idiopathic Dry Eyes
Dry eyes are a very common complaint. In some patients, we can identify the reason for the dryness; however, in others the dryness has no clear cause. Dryness can lead to eye irritation, redness, and sometimes changes in vision.
- Trial name
- NCT01254201
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Michigan
RASopathy, Costello Syndrome
Solid Tumors in RASopathies
RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic…
- Conditions
- RASopathy, Costello Syndrome, Cardio-Facio-Cutaneous Syndrome, Noonan Syndrome
- Trial name
- 4218 (NCT05761314)
- Testing
- Molecular characterization of solid tumor in RASopathies
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Primary Myelofibrosis (PMF), Healthy Subjects
Role of Myeloid-derived Suppressor Cells In Primary Myelofibrosis
The goals of this observational study are to investigate the role of myeloid-derived suppressor cells (MDSCs) in fueling chronic inflammation that is a relevant pathogenetic mechanism in patients with primary myelofibrosis (PMF)…
- Trial name
- NCT07319026
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hyperemesis Gravidarum
The Association of Helicobacter Pylori in the Pathogenesis of Hyperemesis Gravidarum in Pregnant Women
The purpose of this study to explore the association between Hyperemesis Gravidarum in pregnant women and Helicobacter pylori infection.
- Trial name
- AOHPIPOHGIPW (NCT02830321)
- Testing
- helicopacter pylori stool antigen test (CER TEST BIOTEC)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- rasha fawzy abd el kader
Psychosis
Measurments Of BBB Breakdown In The Pathogenesis Of Psychiatric Disorders
BBB dysfunction has been indicated in some groups of schizophrenia patients by measuring increased albumin and immunoglobulin (IgG) cerebrospinal fluid (CSF) levels.
- Trial name
- NCT01396850
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center