Clinical trials: Pathogenesis
Age-related Macular Degeneration
Impact of Visceral Fat on the Pathogenesis of Age-related Macular Degeneration
The purpose of this study is to determine the relationship among the body fat distribution, especially the visceral fat, in patients with age-related macular degeneration in comparison to patients with a normal fundus.
- Trial name
- NCT01777984
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rudolf Foundation Clinic
Glomerulonephritis, IGA
Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy
Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy.
- Trial name
- NCT00521508
- Testing
- gene transcription and cytometry
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
To Compare the Serum Apoptosis-associated Markers Between Patients With Active TB and Patients With LTBI, To Evaluate the Efficiency of Apoptosis-associated Markers to Differentiate Potential of Active TB From LTBI
The Role of Apoptosis Associated Markers in Pathogenesis of Pulmonary Tuberculosis
To compare the serum apoptosis-associated markers between patients with active TB and patients with LTBI To evaluate the efficiency of apoptosis-associated markers to differentiate potential of active TB from LTBI
- Trial name
- NCT01676155
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Subarachnoid Hemorrhage, Terson Syndrome
The Pathogenesis of Terson Syndrome and the Role of CSF Tau / Amyloid-ß 40 and 42 in Patients With Aneurysmatic Subarachnoid Hemorrhage
Prospective clinical study to investigate the pathogenesis of Terson syndrome and the prognostic value of the CSF-biomarkers tau-protein and amyloid-β 40 and 42 in patients with aneurysmatic subarachnoid hemorrhage.
- Conditions
- Subarachnoid Hemorrhage, Terson Syndrome, CSF-proteines
- Trial name
- NCT02129010
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Holger Joswig
Periodontal Diseases
Analysis of Gingival Crevicular Fluid
The purpose of this study was to investigate and compare GCF interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-36γ (IL-36γ) levels in patients with healthy (H), gingivitis (G) and chronic periodontitis (CP) status.
- Trial name
- GCF (NCT05325905)
- Testing
- Gingival crevicular fluid sampling
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
PreDiabetes
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
We recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1.
- Trial name
- NCT06967558
- Testing
- Exendin 9-39, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes
Evaluation of Zinc in Patients With Type 2 Diabetes
investigation of the impact of zinc level on the development of DM and to elaborate on whether daily consumption of zinc affects the disease's evolution.
- Trial name
- NCT06751823
- Where
- Egypt
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Heliopolis University
Idiopathic CD4+ Lymphocytopenia, Cryptococcal Meningitis
Etiology, Pathogenesis, and Natural History of Idiopathic CD4+ Lymphocytopenia
Background: Idiopathic CD4+ lymphocytopenia (ICL) is a condition in which there is a decreased level of CD4+ lymphocytes (a type of white blood cell), which can lead to opportunistic infections or autoimmune disorders and…
- Conditions
- Idiopathic CD4+ Lymphocytopenia, Cryptococcal Meningitis, Warts
- Trial name
- NCT00867269
- Where
- United States
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mycobacterium Tuberculosis, LTBI (Latent TB Infection)
The Influence of Malnutrition, Diabetes Mellitus, and Helminth Infections on Biosignatures in Latent Tuberculosis in a South Indian Population
About 2 billion people worldwide are infected with tuberculosis (TB). Ninety percent of those people have latent TB infection (LTBI).
- Conditions
- Mycobacterium Tuberculosis, LTBI (Latent TB Infection), Malnutrition, Diabetes Mellitus
- Trial name
- NCT04526613
- Where
- India
- Volunteers
- 626 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Duchenne / Becker Muscular Dystrophy, Dystrophia Myotonica 1
Evaluation of the Role of miR-1 in the Pathogenesis and as a Biomarker in Muscular Dystrophies and Congenital Myopathies
The study aims to find out if a specific blood molecule called miR-1, can be used as a biomarker to track the health of patients with certain muscle diseases.
- Conditions
- Duchenne / Becker Muscular Dystrophy, Dystrophia Myotonica 1, Congenital Myopathies, Healthy Participants
- Trial name
- Dystro-miR1 (NCT07415837)
- Testing
- dosage of blood biomarker miR1
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Immature Platelets, Deep Venous Thrombosis
Immature Plateletes in the Etiopathology of Deep Venous Thrombosis
The study is designed to evaluate the role of platelets and immature platelets in the ethiopathology of deep venous thrombosis and pulmonary embolism.
- Trial name
- iPLATELET (NCT02361294)
- Testing
- Blood samples
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Fabry's Disease
Analysis of the Nervous System in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme ceramidetrihexosidase. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Trial name
- NCT00001491
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Periapical Periodontitis
The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis
A total of 185 subjects were divided into three categories: AP group (n=85), CP group (n=50) and healthy control group (n=50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI) based on the…
- Trial name
- NCT06023901
- Testing
- Apical periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Glaucoma, Corneal Transplantation
Inflammatory Mediators of Glaucoma After Corneal Transplantation (AH-Tears)
Glaucoma is the most common threat to vision rehabilitation in patients with Boston keratoprosthesis type 1 (KPro) implantation.
- Conditions
- Glaucoma, Corneal Transplantation, Inflammation
- Trial name
- AH-Tears (NCT04339907)
- Testing
- Sampling of tears, Sampling of aqueous humor
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Vitiligo
Histochemical Study of Vitiligo in Sohag University Hospital Patients
Vitiligo is a common acquired idiopathic disorder characterized by depigmentation of the skin, hair, and mucous membranes in the form of macules and patches due to selective melanocyte destruction .
- Trial name
- NCT05869942
- Testing
- Light microscopic studies, Immunohistochemical studies
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Periimplantitis, Microbial Colonization
The Effect of Smoking on Peri-implantitis
the primary aim of this project is to evaluate the microbiological and inflammatory effect of smoking status and smoking severity on periimplantitis lesions.
- Conditions
- Periimplantitis, Microbial Colonization, Cytokines
- Trial name
- NCT06150066
- Testing
- Recruiting samples
- Where
- 2 sites in Switzerland, Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Chronic Myelomonocytic Leukemia
The Expression of PTEN Protein and mRNA in Malignant Cells of Chronic Myelomonocytic Leukemia
The purpose of this study is to evaluate the level of a specific protein (PTEN) in the cancer cells of chronic myelomonocytic leukemia (CMML) patients.
- Trial name
- NCT01010256
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Postoperative Complications, Elderly
Elderly Patients Undergoing Surgery During Perioperative Period
The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher.
- Conditions
- Postoperative Complications, Elderly, Postoperative Delirium (POD), Risk Prediction Model
- Trial name
- NCT07314762
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Autoimmune Uveitis, Behçet Disease
Pilot Project: The Amplicon and Metatranscriptomic Study of Intra and Extra Intestinal Microbiome in Non-infectious Uveitis Disease
This study aimed to discover the composition on the microbiome in several sites of the human body; and to find out the difference in microbiome composition on ocular fluid, blood, and feces before and after therapy in uveitis…
- Conditions
- Autoimmune Uveitis, Behçet Disease, Vogt-Koyanagi-Harada Disease, Idiopathic Uveitis
- Trial name
- NCT04126850
- Where
- Indonesia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Rhinovirus
The Rhinovirus Hospitalization and Investigation of Nasal-airway Omics (RHINO) Study
The goal of this study is to determine the burden of Rhinoviruses (RVs) as a cause of acute, severe, respiratory illnesses leading to hospitalization.
- Trial name
- NCT07342582
- Testing
- Nasal Swab Healthy Surveillance, Nasal Swab Sick Samples, Nasal Swab Hospitalized Cohort
- Where
- United States
- Volunteers
- 670 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison