Clinical trials: Pathologic Response
Circadian Rhythm Disorders, Sepsis
Functionality of Endogenous Biological Clock in Sepsis
The aim of the current study is to demonstrate dysregulation of immune system΄s circadian rhythms as a consequence of sepsis, as well as marked malfunction of the central circadian clock in comparison with patients without sepsis…
- Trial name
- NCT04063332
- Where
- 2 sites in Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Salmonella Infections, Infection of Bloodstream
Reservoir of Invasive Salmonellosis in Children, DRC
Bloodstream infections caused by non-typhoid Salmonella (NTS) are a major killing disease in Sub-Saharan Africa. Despite the high case fatality rate, the main reservoir -human, zoonotic or environmental- for invasive NTS rests…
- Trial name
- NCT03073707
- Testing
- Sample collection
- Where
- Democratic Republic of the Congo
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Sepsis
Infrared Imaging in Septic Illness
The application of infrared thermal imaging in the diagnosis and prognostication of septic illness in adults. During times of severe infection (sepsis), the small blood vessels supplying oxygen and nutrients to the skin and other…
- Trial name
- NCT02855671
- Testing
- Infrared thermal imaging
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Birth Asphyxia, Very Low Birth Weight Baby
Naushero Feroze Neonatal Survival Project
The present study will be carried out in close collaboration with the National Program for Lady Health Workers, a Ministry of Health program with 100,000 Lady Health Workers covering 60% of the rural population of Pakistan.
- Conditions
- Birth Asphyxia, Very Low Birth Weight Baby, Neonatal Sepsis
- Trial name
- AKU (NCT01350765)
- Testing
- Intervention, Control
- Where
- Pakistan
- Volunteers
- 37,201 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Nociceptive Pain, Anesthesia
Cerebral and Autonomic Responses to Pain in Healthy Humans
Evaluating the intraoperative pain is a major challenge for the anesthesia team. During anesthesia, changes in heart rate and blood pressure are interpreted qualitatively to evaluate the sympathetic response to nociceptive…
- Conditions
- Nociceptive Pain, Anesthesia, Healthy
- Trial name
- ALGOBLOC-1 (NCT04925336)
- Testing
- Nociceptive stimulation
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Pain
Breast Feeding Analgesia in Preterm Infants
The purpose of this study is to compare the effects of mothers' breastfeeding with the effects of pacifier sucking on preterm infant biobehavioural responses during and immediately after a painful procedure Hypothesis: 1.
- Trial name
- NCT00175409
- Testing
- Blood collection
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sleep Disorders
Characteristics of Sleep Patterns in Young Adults With and Without Insomnia
This study will compare the symptoms, experiences, and laboratory sleep characteristics of young adults with and without insomnia.
- Trial name
- NCT00177216
- Testing
- Zolpidem, Escitalopram
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Type2 Diabetes, Insulin Resistance
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes
Type 2 diabetes are characterized by insulin resistance in skeletal muscle. Insulin resistance plays a major role for the increased risk of heart disease seen in type 2 diabetes.
- Trial name
- NCT03500016
- Testing
- High intensity interval training
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Inflammatory Response, Metabolic Disturbance
Acute Inflammatory and Metabolic Effect of High Fructose Intake
Fructose consumption is associated with the development of metabolic diseases and low-grade inflammation. However, the acute effect of a single meal rich in fructose on the metabolic and inflammatory response is not fully…
- Trial name
- NCT05573438
- Testing
- Group fructose, Group Sucrose, Group Glucose
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Adaliene Versiani M. Ferreira
Age Related Macular Degeneration, Retinitis Pigmentosa
Visual Activity Evoked by Infrared in Humans After Dark Adaptation
This pilot study will evaluate the visual response to infrared (IR) in humans after dark adaptation. The investigators plan to determine which wavelength and intensity the human eye is most sensitive to in healthy and color-blind…
- Conditions
- Age Related Macular Degeneration, Retinitis Pigmentosa, Congenital Stationary Night Blindness, Colorblindness
- Trial name
- NCT02909985
- Testing
- Tungsten halogen light with narrow bandpass filters
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Inflammatory Response, Microbial Colonization
Microbial Adhesion and Biofilm Formation on Denture Base Materials
Polymethylmethacrylate (PMMA) has been the material of choice for fabricating complete dentures for more than 80 years now.(1,2) As a material it is easy to handle and can be easily repaired and polished.
- Conditions
- Inflammatory Response, Microbial Colonization, Denture Stomatitis
- Trial name
- NCT06395116
- Testing
- Denture base material
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Obesity
A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide
The purpose of this study is to identify how certain parts of the brain that help control body weight respond to an infusion of hormones called leptin and amylin.
- Trial name
- NCT00691158
- Testing
- Pramlintide (Amylin), 2 Metreleptin, Leptin plus Pramlintide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Stress, Job, PTSD
The Sequestration of Holistic Stress Management Techniques for Adults
This remote study is intended to assist the population with access to cost-effective pastoral counseling for stress management in the workplace and every day life.
- Conditions
- Stress, Job, PTSD, Hypervigilance, Hyperthyroidism
- Trial name
- NCT06098755
- Testing
- Holistic Medicine (HM)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Goddess Zena I. Jones
Sepsis
Defining Circulating Micro-RNA Biomarkers for the Early Diagnosis and Prognosis of Sepsis
The objectives are to: 1. derive and validate a panel of miRNAs that are consistently differentially expressed in the plasma of patients with and without sepsis 2.
- Trial name
- miRNA-Sepsis (NCT02544490)
- Where
- Singapore
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Inflammation, Aging
Adaptive Stress Response: The Hot Yoga Study
This is a small intervention study which is aimed at characterizing what is known as the adaptive stress response (also know as "hormesis") in women aged 30-45 years.
- Conditions
- Inflammation, Aging, Depression, Anxiety
- Trial name
- NCT06395376
- Testing
- Bikram Hot Yoga Intervention, Hot Yoga Washout
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Sepsis
Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population
CD163 is a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage.CD163 acts to amplify inflammation and serves as a critical mediator of inflammatory response in…
- Trial name
- NCT01504243
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Hyperglycemia, Diabetes, and Obesity
Effects of Resistant Starch in a Beverage on Post-prandial Glycemic and Insulinemic Responses
Hypothesis: A beverage with a resistant starch will blunt and sustain the post-prandial rise in blood glucose and insulin concentrations compared to beverage with maltodextrin (an easily digested carbohydrate).
- Trial name
- NCT02161250
- Testing
- Resistant Starch, Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Sepsis, Systemic Inflammation
The Effect of Glutamine on Systemic Inflammation During Human Experimental Endotoxemia
Glutamine levels decrease during severe sepsis; this may be associated with increased mortality. The investigators tested the effects of glutamine supplementation on systemic inflammation in a human sepsis model.
- Trial name
- NCT00780520
- Testing
- alanine-glutamine infusion
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men
To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.
- Trial name
- NCT05749523
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vibeke Backer