Clinical trials: Pathological Fractures
Sickle Cell Disease, Sickle Cell Anemia
Sickle Cell Disease (SCD) Bone Pain Study
A prospective study to determine how low bone mineral density and/or vertebral compression fractures associate with pain in adults with sickle cell disease
- Conditions
- Sickle Cell Disease, Sickle Cell Anemia, Low Bone Density, Osteoporosis
- Trial name
- NCT05283148
- Testing
- Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of California, Davis
Hip Fracture, Proximal Femur Fracture
Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery
Hip fractures are serious injuries that occur mostly in older adults. Many people experience health problems or may die in the months after surgery.
- Conditions
- Hip Fracture, Proximal Femur Fracture, Frailty
- Trial name
- NCT07481188
- Testing
- No Intervention: Observational Cohort
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Trakya University
Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck
Z1 Hip System: Post-Market Clinical Follow Up Study
The objectives of this study are to confirm the early to mid- term safety, performance, and clinical benefits of the Z1 Femoral Hip System in hemi- and primary total hip arthroplasty.
- Conditions
- Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck, Avascular Necrosis of the Femoral Head
- Trial name
- NCT07104279
- Testing
- Z1 Femoral Hip System
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Zimmer Biomet
Amputation, Fracture
Bone Physiology & Mechanics in Osteomyoplasty Amputation Rehabilitation
The purpose of the study is to compare the effect of different lower limb amputation surgical procedures on leg bone integrity and rehabilitation outcome.
- Conditions
- Amputation, Fracture, Inflammation, Osteoporosis
- Trial name
- NCT00271362
- Testing
- Amputation rehabilitation exercise program, Osteomyoplasty vs. routine long posterior flap
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- VA Office of Research and Development
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Hip Fractures, Anesthesia
Delirium in Elderly Patients With Trauma of the Hip
A broken hip occurs frequently in elderly patients and is often very painful. Side effects of inadequately treated pain as well as the traditional drugs (administered through intravenous catheter) used to treat pain are, among…
- Trial name
- DEPTHip (NCT02689024)
- Testing
- Bupivacaine, Acetaminophen, Diclofenac
- Where
- 5 sites in Netherlands
- Volunteers
- 239 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
HİP FRACTURE, Hip Surgery (Lateral Incision)
Perioperative Analgesic Effects of PENG Versus PENG Plus LFCN Block in Hip Surgeries
This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared.
- Conditions
- HİP FRACTURE, Hip Surgery (Lateral Incision), Postoperative Pain Management, Analgesia, Postoperative
- Trial name
- NCT07329829
- Testing
- Pericapsular nerve group (PENG) block, Lateral Femoral Cutaneous Nerve (LFCN) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Osteoarthritis, Pain
Patellar Resurfacing in Total Knee Arthroplasty
Background: The best treatment of the patella during total knee arthroplasty (TKA) is controversial. The implantation of a patellar component adds to the operation time and the costs of the operation.There is a huge variation as…
- Trial name
- NCT00553982
- Testing
- Patellar component, No patellar component
- Where
- Norway
- Volunteers
- 130 people
- Sponsor
- Sykehuset Innlandet HF
Bleeding, Complications
Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery
It is well known that femoral neck fractures carry a significant increase in patients' mortality and that surgical intervention is the preferred treatment.
- Trial name
- NCT00905229
- Testing
- Phytonadione
- Where
- Israel
- Sponsor
- HaEmek Medical Center, Israel
Back Pain
To Evaluate Success of Cement Treatment of Spinal Compression Fractures
Patients with vertebral compression fracture will be treated cement injection into the spine and monitored using standard evaluations.
- Trial name
- NCT00166374
- Testing
- balloon kyphoplasty
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Distal Radius Fracture, Postoperative Pain
Regional or General Anesthesia for Distal Radius Fracture Surgery in a Day Surgery Setting
The purpose of this study is to compare general and regional anesthesia with regard to postoperative pain in patients who undergo surgery in a day surgery setting due to a displaced distal radius fracture.
- Trial name
- NCT02495688
- Testing
- Regional anesthesia, General anesthesia
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Postoperative Delirium, Hip Fractures
Association Between Preoperative Hyperglycemia and Postoperative Delirium in Geriatric Hip Fracture Patients
This retrospective study aims to collect electronic medical record data from Dandong central hospital spanning from January 2013 to November 2023.
- Conditions
- Postoperative Delirium, Hip Fractures, Hyperglycemia
- Trial name
- NCT06473324
- Where
- China
- Volunteers
- 2,031 people
- Sponsor
- Wenbo Ding
Osteoporotic Fracture
Effectiveness or Orthopedic Intervention in Osteoporosis Management After a Fracture of the Hip With Cost-Benefit Analysis
Patients who present with fragility fractures are consistently under-evaluated and under-treated for underlying osteoporosis. This point of care represents a lost opportunity to prevent future fractures.
- Trial name
- NCT02239523
- Testing
- Letter Group, Intervention Group
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Shaare Zedek Medical Center
Methadone, Pain, Post Operative
Perioperative Methadone in Hip Fracture Patients
Postoperative analgesic treatment needs to be improved. Numerous studies suggest that a single dose of Methadone given during surgery significantly ameliorates postoperative pain and reduces postoperative opioid consumption.
- Conditions
- Methadone, Pain, Post Operative, Pain, Postoperative, Analgesics, Opioid
- Trial name
- NCT05581901
- Testing
- Methadone (Dose1), Methadone (Dose 2), Methadone (Dose 3)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- University of Southern Denmark
Intertrochanteric Femur Fracture, Muscle Atrophy
Intertrochanteric Femur Fracture Patients Who Receive Metformin With a Placebo
The investigators central hypothesis is that metformin supplementation will be well-tolerated, safe, and provide patients with improved functional and muscle morphology outcomes following intertrochanteric femur fracture.
- Trial name
- NCT07179042
- Testing
- Metformin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Hip Fracture, Pain Management
Comparison of the Efficacy of Ultrasound-guided Supra-inguinal Fascia Iliaca and Lumbar Erector Spina Plan Block in Hip Fractures
The aim of our study was to evaluate the efficacy and patient satisfaction level of SI-FIB and lumbar ESPB for positioning and postoperative analgesia during spinal anesthesia in patients undergoing hip fracture surgery.
- Conditions
- Hip Fracture, Pain Management, Multimodal Analgesia, Peripheral Nerve Block
- Trial name
- NCT07639762
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Hip Fracture, Sarcopenia
Regional Muscle Balance and Hip Fracture Patterns
Hip fractures are common in older adults and are often associated with muscle loss and frailty. While many studies focus on overall muscle reduction (sarcopenia), the role of regional muscle balance around the hip remains…
- Conditions
- Hip Fracture, Sarcopenia, Muscle, Frailty
- Trial name
- NCT07443046
- Where
- Turkey (Türkiye)
- Volunteers
- 79 people
- Sponsor
- Ankara City Hospital Bilkent
Arthritis, Arthritis, Degenerative
Clinical Evaluation of the TITAN™ Total Shoulder System
A post market, non-randomized, multi-center, open-label,clinical study using survivorship to study the safety and efficacy of the Integra® TITAN™ Total Shoulder System 1.0 (TAS) when used for total shoulder arthroplasty.
- Conditions
- Arthritis, Arthritis, Degenerative, Rheumatoid Arthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region
- Trial name
- NCT03245320
- Testing
- Integra TITAN™ Total Shoulder Generation 1.0
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Smith & Nephew, Inc.
Pain
Dexmedetomidine-ketamine in Femur Proximal Fracture Patients
Comparison study of analgesic effects for dexmedetomidine-fentanyl vs dexmedetomidine-ketamine lateral position for spinal anesthesia in femur proximal fracture patients
- Trial name
- NCT02150759
- Testing
- Dexmedetomidine, Fentanyl, Ketamine
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Inje University
Alzheimers Disease, Inflammation
Alzheimers Disease and Neuromarkers in Patients With Acute Hip Fractures
The investigators explore the presence of AD factors beta-amyloid and tau in CSF and plasma to verify AD diagnosis in patients with acute hip fracture. Clinical dementia test is performed prior to operation.
- Conditions
- Alzheimers Disease, Inflammation, Hip Fracture
- Trial name
- ADhipfract (NCT02409082)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital