Clinical trials: Pathological Fractures
Next Generation Sequencing (NGS), Surgical Site Infection (SSI)
Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:
The study focuses on the serious problem of infections and wound-healing issues that can happen after high-energy bone fractures.
- Conditions
- Next Generation Sequencing (NGS), Surgical Site Infection (SSI), Fracture Fixation
- Trial name
- NGS (NCT07458230)
- Testing
- NGS diagnostic findings
- Where
- 18 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Pelvic Pain
Treatment of Pelvic Ring Fractures in the Elderly
Pelvic ring fractures in the elderly are associated with high morbidity during standard conservative treatment due to immobility. Furthermore the risk of long term dependence even after the fracture has united is high.
- Trial name
- NCT02590783
- Testing
- experimental intervention surgery, control intervention
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- University Hospital, Basel, Switzerland
Delirium - Postoperative, Hip Fractures (ICD-10 72.01-72.2)
Effect of Transcranial Direct Current Stimulation on Postoperative Delirium in Elderly Patients
To evaluate the efficacy of transcranial direct current stimulation (tDCS) in reducing the incidence of postoperative delirium (POD) in elderly patients undergoing hip fracture surgery.
- Trial name
- NCT06678529
- Testing
- active tDCS
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huazhong University of Science and Technology
Postoperative Pain
Fascia Iliaca Compartment Block Versus Anterior Quadratus Lumborum Block
Fractures of the femur are common orthopaedic emergency especially in the geriatric population and central neuraxial blocks are the preferred technique for providing anaesthesia.
- Trial name
- NCT04709211
- Testing
- Facia Iliaca block, Anterior Quadratus Lumbroum block, bupivacaine
- Where
- Egypt
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Postoperative
Norspan Versus Oxycontin as Postoperative Painkiller to Proximal Extracapsular Fractures of the Femur
Effective treatment of pain after hip fractures is very important but difficult. It is often an old patient who has many adverse effects with the use of morphine.
- Trial name
- NCT00964808
- Testing
- Buprenorphine, Oxycodone
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Vejle Hospital
Hip Fracture Surgeries
Preoperative Analgesia: The Effectiveness of the PENG Block in Patients With Hip Fractures
The aim is to provide effective preoperative analgesia in patients undergoing surgical procedures due to hip fractures by administering a pericapsular nerve group (PENG) block under ultrasound guidance.
- Trial name
- NCT07003633
- Testing
- PENG block with 0.25% bupivacaine guided by ultrasound.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Skull Fractures, Stroke
Simulation Training in Emergency Department Imaging 2
Background and study aims: Computerised Tomography (CT) head scans are frequently requested by Emergency Department (ED) clinicians as one of the investigations for their patients.
- Conditions
- Skull Fractures, Stroke, Intracranial Bleed, Brain Tumor
- Trial name
- STEDI2 (NCT05427838)
- Testing
- Online training
- Where
- 6 sites in United Kingdom
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Collum Femoris Fracture, Pericapsular Nerve Group Block
the Pericapsular Nerve Group (PENG) and Suprainguinal Fascia Iliaca Blocks (SIFIB) in Elderly Patients
This clinical trial aims to compare the effect of the pericapsular nerve group (PENG) and suprainguinal fascia iliaca blocks (SIFIB) on pain management in elderly patients with subtrochanteric femur fractures.
- Conditions
- Collum Femoris Fracture, Pericapsular Nerve Group Block, Suprainguinal Fascia Iliaca Block
- Trial name
- NCT06277648
- Testing
- PENG block, SIFIB
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Haseki Training and Research Hospital
Frailty, Hip Fracture
Frailty, Hip Fractures and Inflammatory Biomarkers
We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.
- Conditions
- Frailty, Hip Fracture, Inflammatory Biomarkers
- Trial name
- NCT06614478
- Where
- 2 sites in Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Humerus Fracture Metastatic Bone Disease
Safety and Efficacy Study of Treatment of Pathological Fractures in Humerus
This study will collect safety and performance data of the Photodynamic Bone Stabilization System (PBSS) when used for the treatment of fractures of the humerus secondary to metastatic cancer.
- Trial name
- NCT02338492
- Testing
- Photodynamic Bone Stabilization System
- Where
- 13 sites in United States
- Volunteers
- 81 people
- Sponsor
- IlluminOss Medical, Inc.
Ankle Fractures
Cryotherapy Reduces Time to Surgery and Local Complication in Patients With Ankle Fractures
Ankle fractures are common injuries and cryotherapy is routinely used to reduce pain, swelling and local skin complications, both before and after surgery. However, the results on ankle surgery are contradictory.
- Trial name
- Cryotherapy (NCT06396364)
- Testing
- Cryotherapy
- Where
- 2 sites in Italy
- Volunteers
- 169 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Osteoporosis
Recognizing Osteoporosis and Its Consequences in Quebec (ROCQ) Programme
The aim of the ROCQ programme is to improve the use of evidence based osteoporosis diagnostic and treatment strategies for women 50 years and over who have suffered a fragility fracture.
- Trial name
- NCT00359047
- Testing
- Documentation, Video
- Where
- Canada
- Volunteers
- 2,830 people
- Sponsor
- CHU de Quebec-Universite Laval
Elbow Fracture
Percutaneous Pin Removal in Children - is Analgesia Necessary?
This is a simple randomised clinical trial to study if non-narcotic analgesia reduces the pain score and pulse rate of children who undergo removal of percutaneous pins in the outpatient clinic.
- Trial name
- NCT01944085
- Testing
- Acetaminophen, Ibuprofen, Vitamin C
- Where
- Singapore
- Volunteers
- 240 people
- Sponsor
- KK Women's and Children's Hospital
Ankle Fractures, Anesthesia, Local
High Ankle Block in Ankle Fractures
The aim of the herein presented double-blinded is to compare the effectiveness of the high foot block against placebo infiltration in simple, uni- and bimalleolar ankle fractures.
- Trial name
- NCT04292691
- Testing
- 40ml of Ropivacaine 0.5% Injectable Solution, 40ml of Ringer's Lactate
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Stress Reaction, Sleep Disturbance
Functional Assessment of Ashwagandaha Root Extract During Weight Loss
Patients who are involved in a clinical protocol driven 12 week medical weight loss intervention will be randomized to receive either a placebo or 600 mg of an ashwagandha root extract.
- Conditions
- Stress Reaction, Sleep Disturbance, Craving, Obesity
- Trial name
- NCT03112824
- Testing
- Ashwagandha Root Extract Capsule
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Post-traumatic Carpal Tunnel Syndrome, Complex Regional Pain Syndrome
Use of Compression Glove to Prevent Complications After Distal Radius Fractures: a Randomized Controlled Trial
Distal radius fractures (DRF) are the most common type of fracture in the human body, and a large proportion of DRFs result in complications.
- Conditions
- Post-traumatic Carpal Tunnel Syndrome, Complex Regional Pain Syndrome, Edema
- Trial name
- NCT01118715
- Testing
- Compression glove
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- J&M Shuler
Mandible Fracture, Edema Face
Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures
The rationale of the current research is to address the limitation of existing knowledge as it is not clear which of the two drugs (Dexamethasone or Methylprednisolone) is more effective in reduction of postoperative sequelae in…
- Conditions
- Mandible Fracture, Edema Face, Pain Management, Corticosteroid Injection
- Trial name
- NCT07208799
- Testing
- Dexamethasone, Methylprednisolone (Corticosteroid)
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Nishtar Medical University
Osteoarthritis, Avascular Necrosis
A Clinical Investigation of the Comprehensive®, BioModular®, and Bi-Angular® Shoulder Systems
The purpose of this prospective clinical data collection is to document the performance and clinical outcomes of Biomet Humeral Stems
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Humeral Fractures
- Trial name
- NCT00699270
- Sponsor
- Biomet Orthopedics, LLC
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Blood Loss, Surgical, Hip Fractures
Single Dose of Tranexamic Acid and Blood Loss, in Elderly Patients With Hip Fracture
The aim of this study is to investigate the hypothesis that single dose of tranexamic acid (TXA) preoperatively will lower blood loss and transfusion rate in elderly patients with hip fractures (intertrochanteric or Subcapital)…
- Conditions
- Blood Loss, Surgical, Hip Fractures, Complication, Postoperative
- Trial name
- NCT03251469
- Testing
- Tranexamic Acid 15mg/kg , iv, Single Dose, Normal Saline, 100mg, iv, Singe dose
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens