Clinical trials: Pathological Processes
Idiopathic Thrombocytopenia Purpura
A Study to Evaluate the Relative Bioavailability and Intra-Subject Variability of Two Lots of E5501 40 mg Tablets Administered Twice as Single Oral Doses to Healthy Subjects
The purpose of this study is to evaluate the relative bioavailability (BA) of two lots of E5501 40 mg tablets administered twice as single oral doses to healthy subjects.
- Trial name
- NCT01289509
- Testing
- E5501, Drug: E5501
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Frailty
A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients With Aging Frailty
The goal of this phase I/II clinical trial is to evaluate the safety and tolerability of intravenous infusion of human allogeneic bone-marrow-derived mesenchymal stromal cell product StromaForte in patients with aging frailty.
- Trial name
- NCT06070532
- Testing
- Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- The Bahamas
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cellcolabs Clinical LTD.
Chronic Obstructive Pulmonary Disease
A Study to Assess Safety, Tolerability and Pharmacokinetics of of AZD6553 in Healthy Volunteers and Patients With Chronic Obstructive Pulmonary Disease (COPD)
AZD6553 is a new drug being developed as a possible treatment for patients with chronic obstructive pulmonary disease (COPD). COPD refers to chronic bronchitis and emphysema, a pair of two commonly co-existing diseases of the…
- Trial name
- NCT01068184
- Testing
- AZD6553
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity, Sarcopenia
Biological Effects of Weight Loss In Older, Obese Women
Obesity and sedentary lifestyle are associated with physical impairments and biological changes in older adults. Weight loss combined with exercise may reduce inflammation and may improve physical functioning in older adults who…
- Trial name
- WL+E (NCT01032733)
- Testing
- Lifestyle Counseling, Educational Control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Florida
Hemorrhage Postpartum
Sublingual Misoprostol to Reduce Blood Loss During Elective Cesarean Delivery
Sublingual Misoprostol to Reduce Blood Loss During Elective Cesarean Delivery : A Randomized Controlled Trial
- Trial name
- NCT03140033
- Testing
- Misoprostol Oral Tablet, Ranitidine Oral Tablet
- Where
- Egypt
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Cardiovascular Disease
Beta-Blocker Influences on Inflammatory and Neural Responses to Stress
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
- Trial name
- NCT06263452
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Muscle Weakness
Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training
To determine, in a double blind trial, the effects of creatine supplementation during 12 weeks on muscle mass and function of community living older women subjected to resistance training.
- Trial name
- NCT02188849
- Testing
- Resistance exercise training, Creatine
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile
Neurologic Manifestations, Neurobehavioral Manifestations
Training Cognitive Control Processes in Older Adults
Control processes are classes of brain activity that initiate, coordinate, synchronize, and regulate elemental cognitive functions for the conduct of goal-directed behavior.
- Trial name
- NCT00586638
- Testing
- Video game based training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Human Papillomavirus Infection, Cervical Cancer
Clinical Evaluation of Detection of High Risk HPV in Urine
Cervical cancer is one of the most common tumors in women, which seriously threatens women's life quality and safety. Human papilloma virus (HPV) infection is the most common cause of cervical cancer.
- Conditions
- Human Papillomavirus Infection, Cervical Cancer, Human Papilloma Virus, Negative for Intraepithelial Lesion or Malignancy
- Trial name
- Urine-hrHPV (NCT05210348)
- Where
- 3 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Twin Diseases
Diagnosis and Intervention of Complicated Twin Diseases
Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been…
- Trial name
- NCT03650985
- Testing
- Fetoscope technique
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
COVID-19
Impact of Long COVID-19 on the Health and Quality of Life of Military Personnel (Active or Retired) and Their Families
Severe and sometimes irreversible sequelae are observed in people who have developed a severe form of COVID-19 (pulmonary, cardiovascular, renal, neurological sequelae among others).
- Trial name
- IMP@LA (NCT05200832)
- Testing
- Online questionnaire, Semi-structured interview
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Human Papillomavirus, Uterine Cervical Neoplasms
An HPV Vaccine Provider Intervention in Safety Net Clinics
The purpose of this study is to develop, deliver and evaluate a provider intervention for mothers and their children to encourage receipt of the human papillomavirus (HPV) vaccine in the children and appropriate cervical cancer…
- Trial name
- NCT02808832
- Testing
- Educational materials
- Where
- United States
- Volunteers
- 806 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Neonatal Jaundice
The Effect of Skin Color Scale Material Used by Families at Home in the Postnatal Period on the Process of Hospital Admission Due to Jaundice and Breastfeeding Parameters
The aim of this research is to evaluate the effect of the Skin Color Scale Material used by families in the postnatal period on the hospital admission process due to jaundice and breastfeeding parameters.
- Trial name
- NCT07386093
- Testing
- Experiment Group, control group
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Coronary Artery Disease (CAD), Coronary Artery Calcification
Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)
SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force.
- Conditions
- Coronary Artery Disease (CAD), Coronary Artery Calcification, Occupational Diseases, Aviator's; Disease
- Trial name
- SUSPECT (NCT05508893)
- Testing
- CT Angiography, Exercise stress test
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Uterine Fibroids, Vaginal Bleeding
Optimal Order of Concurrent Office Hysteroscopy and Endometrial Biopsy
This study will look at the optimal order in which to perform concurrent office hysteroscopy and endometrial biopsy in female patients who present for evaluation of abnormal uterine bleeding at a fibroid and endometriosis…
- Trial name
- NCT02472184
- Testing
- Office hysteroscopy, Endometrial biopsy
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Postoperative Pain
Comparison of ESP Block Versus Serratus Block
Total 60 patients, American society of anaesthesiology physical status I-II aged between 18-65 who underwent totally mastectomy will recruit to the study. The patients randomly divided into two groups.
- Trial name
- NCT03619447
- Testing
- ESP block group, serratus block group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection, Exacerbation of COPD
- Trial name
- MRVCOPD (NCT07112235)
- Testing
- Rhinovirus-A16
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Prediabetic State, Diabetes Mellitus, Type 2
Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals
The aim of this study to investigate and compare cardiorespiratory fitness (CRF) parameters of prediabetic, type 2 diabetic and healthy individuals.
- Conditions
- Prediabetic State, Diabetes Mellitus, Type 2, Cardiorespiratory Fitness, Inflammation
- Trial name
- NCT03823664
- Testing
- Cardiorespiratory Fitness
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University