Clinical trials: Pathology, Molecular
Oral Submucous Fibrosis
Effect of Laser Photobiomodulation in Improving Mouth Opening in Oral Submucous Fibrosis
This a patient and outcome assessor blinded, multiple arm, randomized placebo controlled clinical trial. The goal of the study is to study the adjunctive effect of 940nm laser photobiomodulation therapy (PBMT) in precancerous…
- Trial name
- OSMFPBMT (NCT06639009)
- Testing
- 940nm diode laser photobiomodulation, Conventional non -Invasive management in Oral Submucous fibrosis
- Where
- India
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Dr. Shalini Gupta
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Elderly, Sarcopenia
Human Muscle Gene Expression Profiles in Young and Old Men
To reach the goals of living longer in better medical conditions, many countries reach the same conclusion: new strategies have to be developed to avoid, or at least limit, the effects of age; this requires a better knowledge of…
- Trial name
- CERA (NCT00725166)
- Testing
- Skeletal muscle aging
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
PARKINSON DISEASE (Disorder), Atypical Parkinsonism
Early Molecular Biomarkers for Differentiating Parkinsonian Syndromes
This prospective observational study aims to identify and preliminarily validate molecular biomarkers, including microRNAs and metabolites, for the early differentiation of Parkinson's disease (PD) from atypical parkinsonian…
- Conditions
- PARKINSON DISEASE (Disorder), Atypical Parkinsonism, Multiple System Atrophy, Progressive Supranuclear Palsy (PSP)
- Trial name
- BIOMARK-PS (NCT07604883)
- Where
- 2 sites in Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Molecular and Cell Biology in Warsaw
Pulmonary Fibrosis, Lung Cancer
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis Patients
The goal of this study is to investigate the safety of [68Ga]CBP8 and its efficacy to detect collagen deposition in pulmonary fibrosis.
- Trial name
- NCT03535545
- Testing
- [68Ga]CBP8, PET Imaging
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Sepsis, Septic Shock
Molecular Subtype-Specific Mechanisms and Therapeutic Strategies in Sepsis
Sepsis is a complex syndrome that causes lethal organ dysfunction due to an abnormal host response to infection. No drug specifically targeting sepsis has been approved.
- Trial name
- MENDSEP (NCT06287684)
- Where
- Malta
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Mater Dei Hospital, Malta
Isthmocele, Cesarean Scar Defect
Clinical Impact of Uterine Repair During Cesarean Section With Barbed Suture on the Incidence of Isthmocele
Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean…
- Conditions
- Isthmocele, Cesarean Scar Defect, Pelvic Pain, Spotting
- Trial name
- CESARIS (NCT06691750)
- Testing
- Barbed suture, Conventional smooth suture
- Where
- Spain
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Sepsis
Study on the Role of Gamma Delta T Cells in Sepsis Immunosuppression and Its Molecular Mechanism
The purpose of the study is to evaluate the status and function of gamma delta T cells in peripheral blood of sepsis patients.
- Trial name
- NCT02361970
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Chronic Disease
Description of Immunosenescence Biomarkers and Nutritional Intervention to Evaluate the Implementation of Digital Tools
Descriptive comparative study of immunosenescence markers and their association with nutritional, metabolic, metabolomic and genetic characteristics in young (control), senior (age-associated immunosenescence), and populations…
- Trial name
- NCT05807243
- Testing
- Dietary intervention for healthy weight loss
- Where
- Spain
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Glioma
Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we…
- Trial name
- NCT05990244
- Testing
- Magnetic Resonance Elastography, Assessment and Recording
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Nicotine Withdrawal, Marijuana Dependence
Medications Development for the Treatment of Cannabis Related Disorders
The primary objective of this application is to test the neurobehavioral mechanisms and effects of aprepitant as a new cessation agent for cannabis, tobacco or both.
- Conditions
- Nicotine Withdrawal, Marijuana Dependence, Cannabis Dependence, Nicotine Dependence
- Trial name
- MTC (NCT01204723)
- Testing
- Active Aprepitant
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Retinal Degeneration, Retinitis Pigmentosa
Molecular Genetics of Retinal Degenerations
This multinational study will investigate the inheritance of genetic retinal degeneration in families of different nationalities and ethnic backgrounds in order to identify the genes that, when altered, cause retinal…
- Trial name
- NCT00231010
- Where
- 6 sites in United States, China and 2 more
- Volunteers
- 3,549 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Cancer, Cancer Head Neck
Neuroinflammation in Chronic Systemic Symptoms (CSS)
The purpose of the present research protocol is to investigate and identify translocator protein 18kDa, MRI DTI, and EEG/ERPs, markers of Chronic Systemic Symptoms (CSS).
- Conditions
- Cancer, Cancer Head Neck, Neuroinflammatory Response, Chronic Inflammation
- Trial name
- NCT04636723
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer, Colorectal Adenoma
Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp
A study of carcinogenesis-related molecular markers in the patients with colorectal cancer and colorectal adenoma.
- Trial name
- NCT05638542
- Where
- South Korea
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Myocardial Infarction, Myocardial Ischemia
18F-fluorocholine PET-MR Imaging of Coronary Plaque Vulnerability
This study is designed as a prospective observational feasibility study. The investigators will study whether vulnerable plaques on OCT (fibrous cap ≤ 70 μm) show a locally increased uptake of 18F-choline on PET-MRI compared to…
- Conditions
- Myocardial Infarction, Myocardial Ischemia, Atherosclerosis, Coronary Artery Disease
- Trial name
- NCT03252990
- Testing
- PET-MRI, Optical Coherence Tomography
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sepsis, Antigen-presenting Function
Study on Antigen-presenting Function of Gamma Delta T Cells in Sepsis and Its Molecular Mechanisms
Study on antigen-presenting function of gamma delta T cells in sepsis and its molecular mechanisms
- Conditions
- Sepsis, Antigen-presenting Function, γδ T Cells
- Trial name
- NCT03379896
- Testing
- Collect peripheral blood sample
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Leukemia
Molecular Epidemiology of Acute Myelogenous Leukemia
Little is known about the epidemiologic risk factors associated with the development of acute myelogenous leukemia (AML), and less is known about the role that genetic susceptibility plays in the development of AML.
- Trial name
- NCT00502983
- Testing
- Interview
- Where
- United States
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Wound Healing, Cell Proliferation
Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries
In previous in vitro studies it could be shown, that Dexpanthenol has an influence on the gene expression of fibroblasts. The genes which are influenced by Dexpanthenol play mainly a role during cell proliferating processes.The…
- Conditions
- Wound Healing, Cell Proliferation, Gene Expression
- Trial name
- NCT00859196
- Testing
- Dexpanthenol (BAY81-2996)
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bayer
COVID-19, Molecular Sequence Variation
COVID-19 Genomic Sequencing for Nosocomial Outbreak Investigations
This is a tertiary care hospital-based prospective molecular epidemiology study in Montreal, Canada. When nosocomial transmission was suspected by local infection control teams' investigations, SARS-CoV-2 viral genomic sequencing…
- Conditions
- COVID-19, Molecular Sequence Variation, Nosocomial Infection
- Trial name
- NOSO-COVID (NCT05411562)
- Testing
- SARS-CoV-2 genomic sequencing
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)