Clinical trials: Pathology
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Alpha Synuclein Pathology, Alpha-Synuclein
Alpha-Synuclein PET/CT in Various α-Syn-Related Disease
To evaluate the potential usefulness of 18F-FIAT-2, 18F-C05-05, 18F-SPAL-T-06 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various α-Syn-related disease patients.
- Conditions
- Alpha Synuclein Pathology, Alpha-Synuclein, Parkinson Disease
- Trial name
- NCT06949670
- Testing
- 18F-FIAT-2, 18F-C05-05, 18F-SPAL-T-06
- Where
- 3 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University
Sleep Disorders, Neurological Pathologies
Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies
The light has visual and non-visual effects on organism and can act on the behavior, the mood, the cognition and the sleep. These effects are mediated by "classical" retina photoreceptors which allow vision (rods, cones) but also…
- Conditions
- Sleep Disorders, Neurological Pathologies, Psychiatric Pathologies, Ophthalmological Pathologies
- Trial name
- NCT03811964
- Testing
- Specific light exposures
- Where
- France
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Healthy, Pathology
Evaluation of Methodological and Technical DEvelopmeNts to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam on Voluntary Subjects
The EDEN study will make it possible to evaluate one or more development phases (from design to validation through optimization) of a method or a technique on voluntary subjects, in normal or pathological condition.
- Trial name
- EDEN (NCT05218460)
- Testing
- MRI examination
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Short-Term Renal-Hematologic Safety, Contrast-Enhanced MRI and FDG-PET/CT
Comparative Evaluation of Contrast-Enhanced MRI and FDG-PET/CT in Spinal Pathology: Image Quality and Short-Term Renal-Hematologic Safety
This prospective comparative observational study evaluates image quality characteristics and short-term physiological effects associated with contrast-enhanced magnetic resonance imaging (MRI) and fluorodeoxyglucose positron…
- Conditions
- Short-Term Renal-Hematologic Safety, Contrast-Enhanced MRI and FDG-PET/CT, Spinal Pathology
- Trial name
- NCT07640386
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gamification in Oral Pathology Education
Impact of Gamification as Compared to Conventional Teaching Methods Among Dental Students in Egypt
This study is designed to evaluate the effect of gamification-based teaching strategies on learning outcomes and student engagement in undergraduate oral pathology education.
- Trial name
- NCT07563478
- Testing
- Gamification-based Teaching, Traditional Lecture-based Teaching
- Where
- Egypt
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Autism Spectrum Disorder, Mitochondrial Pathology
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders
The study involves up to 5 visits for a fasting blood draw, behavioral assessments, and/or questionnaires. Other samples may be collected when appropriate. This study is currently recruiting.
- Conditions
- Autism Spectrum Disorder, Mitochondrial Pathology, Epilepsy, Brain Tumor
- Trial name
- NCT04322734
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Southwest Autism Research & Resource Center
Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group
ADOLESCENTS IMAGING USING fMRI: Feasibility Study
Impaired social cognition and cognitive control associated with borderline personality disorder (BPD) remain less explored. Recent Franco-Canadian study, has shown the feasibility of a neuroimaging tests in Quebec adolescents…
- Conditions
- Diagnosis of BPD Based on the DIB-R Clinical Interview for the BPD Group, Diagnosis of ADHD Using the KSADS-PL for the ADHD Group, Absence of Pathology on the CBCL and Ab-DIB for the Healthy Control Group, All Participants Were Euthymic at the Time of Task Administration
- Trial name
- ADO IMAGE (NCT07540429)
- Testing
- functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Etablissement Public de la Sante Mentale de la Somme
Sinonasal Pathologies
Assessment of the Morphological Concordance Between CT and Cone Beam in Sinus Imagery
This study compares the morphological concordance between CT (computed tomography) and cone beam in sinus on 26 validated items. CT and cone beam is performed on each patient.
- Trial name
- COSINUS (NCT02397148)
- Testing
- Computed Tomography, Cone Beam Computed Tomography
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing…
- Trial name
- TENS (NCT06541015)
- Testing
- InTENSity 10 TENS Stimulator
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ocular Pathologies
Compact Auto-Aligning Multi-Modal Eye Imaging to Diagnose Traumatic Eye Injury
The purpose of this study is to test an investigational eye imaging device by taking pictures of participants eyes with a single image capture that takes only seconds.
- Trial name
- NCT07218835
- Testing
- Auto-aligning Ocular imaging instrument
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duke University
Pathology Foundation Model
AI Models in Clinical Pathology Diagnosis: A Multicenter RCT
The investigators plan to conduct a multicenter, prospective, randomized controlled trial to systematically evaluate the incremental value of pathology-based artificial intelligence (AI) models in a pan-disease diagnostic…
- Trial name
- NCT07408167
- Testing
- AI model, Control
- Where
- 3 sites in China
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Cerebrovascular Disorders, Brain Lesions
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage
Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative disorders and selective cognitive…
- Conditions
- Cerebrovascular Disorders, Brain Lesions, Degenerative Diseases, Developmental Pathology
- Trial name
- CORAC (NCT01849549)
- Testing
- Neuropsychological testing, MRI
- Where
- France
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
People 60 Years of Age or Over 55 Years of Age With a Diagnosed Pathology and Preferably With a Recognized Physical and/or Cognitive Dependency
A Randomized Controlled Trial to Address a Multimodal Intervention in the Elderly
The study is a quantitative randomized control trial (RCT) with a longitudinal pre-test, mid-test and post-test within and between subject design. It was conducted between July 2023 and December 2024.
- Trial name
- CAMINN (NCT07362381)
- Testing
- Multimodal intervention in the elderly
- Where
- Spain
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Neurological Pathology, Healthy Subjects
[18F]-F13640 as a New Brain Radiopharmaceutical
This clinical assay is designed to validate that [18F]F13640 as a radiotracer of 5-HT1A functional receptors. A first group of healthy subjects underwent a PET scan with arterial blood sampling to determine the kinetic model of…
- Trial name
- F13640 (NCT03347331)
- Testing
- [18F]F13640
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Carcinoma, Renal Cell, Diagnostic Imaging
Deep Learning for Automated Discrimination Between Stage T1-T2 and T3 Renal Cell Carcinoma on Contrast-Enhanced CT
This study aims to develop and validate a contrast-enhanced CT-based deep-learning model for automatic and accurate preoperative discrimination between T1-T2 and T3 renal cell carcinoma.
- Conditions
- Carcinoma, Renal Cell, Diagnostic Imaging, Pathology, Deep Learning
- Trial name
- NCT07166445
- Testing
- None intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Intracranial Pathology, Intracranial Hypertension
Clinical Efficacy of a Non-Invasive Measure of Intracranial Pressure
This study is designed to evaluate the accuracy of a non-invasive method phase-contrast magnetic resonance imaging (MR-ICP) for assessing intracranial pressure (Phase 1).
- Trial name
- MR-ICP (NCT03212976)
- Testing
- Phase contrast magnetic resonance imaging
- Where
- 2 sites in United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Miami
Dementia of Alzheimer Type, Alzheimer Disease
Prevalence of Alzheimer's Disease Pathology in the Community
The goal of this observational study is to (I) study the proportion of people with Alzheimer's disease pathology in a large Norwegian population-based cohort of people aged 70 years or older and to (II) study longitudinal changes…
- Conditions
- Dementia of Alzheimer Type, Alzheimer Disease, Mild Cognitive Impairment, Pathology
- Trial name
- HUNT4AD (NCT06719453)
- Volunteers
- 9,663 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Prostate Cancer, Prostate Intraductal Carcinoma
Artificial Intelligence Models for Precision Prediction and Treatment of Prostate Cancer
The aim of this clinical trial is whether artificial intelligence models can be used for accurate clinical preoperative diagnosis and postoperative diagnosis of pathological findings, and will also measure the accuracy of the…
- Conditions
- Prostate Cancer, Prostate Intraductal Carcinoma, Prostate Cancer Aggressiveness, Prostate Cancer Stage
- Trial name
- NCT06662708
- Testing
- Accurate Prediction Artificial Intelligence Models
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shao Pengfei
Odontogenic Cysts, Keratocysts of the Jaw
Decompression of Odontogenic Cysts
The aim of this case-control study is to evaluate the effects of decompression of cystic jaw lesions by means of comparing pre- and post-decompression histologic findings.
- Conditions
- Odontogenic Cysts, Keratocysts of the Jaw, Cysts Dental, Pathology
- Trial name
- NCT06536907
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Akdeniz University