Clinical trials: Pathology of Pregnancy
Chronic Renal Failure
the Effect of Calcium Dobesilate on Non Dialysis Patients With CKD
To investigate the feasibility of calcium dobesilate in the treatment of microvascular injury provides new ideas and theoretical basis for the prevention and treatment of chronic renal failure.
- Trial name
- NCT03427944
- Testing
- Calcium Dobesilate group, Conventional Treatment group
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Diabetic Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Treatment of Overt Diabetic Nephropathy
Diabetic nephropathy has become the single most frequent cause of end-stage renal disease. On a molecular level, at least five major pathways have been implicated in glucose-mediated vascular and renal damage and all of these…
- Conditions
- Diabetic Nephropathy, Chronic Kidney Disease, Diabetes Type 2
- Trial name
- NCT00556465
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Chronic Kidney Diseases, Hemodialysis Complication
Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis Patients
After the end of trial, we will examine if cholestyramine has a significant efficacy on reducing serum phosphate level in adult hemodialysis patients.
- Conditions
- Chronic Kidney Diseases, Hemodialysis Complication, Hyperphosphatemia
- Trial name
- NCT05577507
- Testing
- Cholestyramine Resin 4000 MG [Questran], Calcium Carbonate 500 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
Chronic Kidney Disease
A Study on Patients With Chronic Kidney Disease (CKD) to Assess Treatment Experience and Patterns, Effect of the Treatment, Patient Outcomes and Patient Quality of Life
DISCOVER CKD is an international observational cohort study in patients with CKD, comprising both prospective and retrospective patient cohorts.
- Trial name
- NCT04034992
- Where
- 43 sites in United States, Italy and 4 more
- Volunteers
- 1,052 people
- Sponsor
- AstraZeneca
Pelvic Floor Disorders
Study of Surgically-Induced Weight Loss on Pelvic Floor Disorders
The specific aim of this study is to evaluate the effect of surgically-induced weight reduction, as achieved by laparoscopic gastric banding or sleeve gastrectomy, on pelvic floor disorders such as stress urinary incontinence…
- Trial name
- NCT00884871
- Testing
- LapBand
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Lupus Nephritis, Diastolic Dysfunction
Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis
This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory…
- Conditions
- Lupus Nephritis, Diastolic Dysfunction, Systemic Lupus Erythematosus, Heart Failure, Diastolic
- Trial name
- NCT07837544
- Volunteers
- 90 people
- Sponsor
- Assiut University
Premature Infants, Very Premature Infants
Anakinra Pilot 2 - A Study to Optimise Dose and Route of Administration of Anakinra in Preterm Infants
A phase 2 randomised, three-arm, parallel-group, dose-ranging trial to determine safety, efficacy and optimal dosing of intravenous anakinra in premature neonates, with subcutaneous pharmacokinetic sub-study.
- Conditions
- Premature Infants, Very Premature Infants, Inflammation
- Trial name
- AP2 (NCT07254000)
- Testing
- Anakinra (Kineret®)
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 24 people
- Sponsor
- Monash Medical Centre
Diabetes Mellitus (Diagnosis), End Stage Renal Disease
Evaluation of Accuracy of Guardian Sensor 3 in Diabetes Patients on Peritoneal Dialysis
Assessment of performance (precision and accuracy) of Guardian Sensor™ 3 as compared with a gold standard reference laboratory method (YSI glucose) in diabetes patients on peritoneal dialysis.
- Conditions
- Diabetes Mellitus (Diagnosis), End Stage Renal Disease, Dialysis
- Trial name
- NCT04776811
- Testing
- Continuous glucose monitoring system
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Elaine Chow
Kidney Failure, Chronic
Study to Compare Initial Dosing Parameters of Zemplar in Stage V Chronic Kidney Disease Subjects on Hemodialysis
To show non-inferiority in the incidence rates of elevated calcium-phosphorus product between two treatment groups: 1) a group having an initial dose based on baseline PTH (baseline iPTH/80) and 2) a group having a starting dose…
- Trial name
- NCT00091481
- Testing
- Zemplar
- Where
- 19 sites in Greece
- Volunteers
- 201 people
- Sponsor
- Abbott
Hypertension, Chronic Kidney Disease.
Effect of Eplerenone in Elderly Hypertensive Early Stage Chronic Kidney Disease (CKD) Patients
The purpose of this study is to determine whether eplerenone is effective in the treatment of blood pressure, heart function, renal function in elderly hypertensive stage1 (eGFR>=90ml/min/1.73m2) and stage2 (eGFR…
- Trial name
- NCT01302236
- Testing
- Eplerenone
- Sponsor
- Jichi Medical University
Chronic Kidney Diseases, Osteodystrophy
Effect of Allopurinol on Markers of Mineral and Bone Metabolism
Hyperuricemia is a common condition in patients with chronic kidney disease (CKD) in the glomerular filtration rate. Recently, it has been suggested that uric acid is related to a mineral and bone disease of CKD (CKD-MBD) since…
- Conditions
- Chronic Kidney Diseases, Osteodystrophy, Uric Acid Concentration, Serum, Quantitative Trait Locus 7
- Trial name
- NCT05601271
- Testing
- Allopurinol
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Renal Cell Carcinoma
Assessment of Bone Biomarkers for TKI Response in RCC With Bone Metastases, HRQoL and Comparison of Imaging Techniques
Prospective observational study to assess bone predictive biomarkers for TKI response in RCC patients with bone metastasis and HRQoL with TKI in these patients as well as the sensitivity and specificity of whole body magnetic…
- Trial name
- METHEOS (NCT02747173)
- Where
- 12 sites in Spain
- Volunteers
- 4 people
- Sponsor
- Spanish Oncology Genito-Urinary Group
Cirrhosis, Hepatorenal Syndrome
Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome
From 1999, several studies have showed that the use of vasoconstrictors in association with albumin are effective in the treatment of hepatorenal syndrome (HRS).
- Trial name
- NCT00742339
- Testing
- Terlipressin plus albumin, Midodrine plus octreotide plus human albumin
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- University of Padova
Pelvic Organ Prolapse, Female Urogenital Diseases
Pelvic Organs Prolapse Treatment Using Neodymium Laser
The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Max" ("Magic Gyno" from August 2024) for preoperative treatment of pelvic organs prolapse I-II degree of severity.
- Trial name
- NCT05000957
- Testing
- Laser Treatment, Blood analysis, Сlinical urine test
- Where
- Russia
- Volunteers
- 129 people
- Sponsor
- MeLSyTech, Ltd
Overactive Bladder Syndrome, Urinary Incontinence, Urge
Effectiveness of Bilateral PTNS Compared to Unilateral PTNS for the Treatment of Overactive Bladder/Urge Incontinence
This study is designed to evaluate whether bilateral Posterior Tibial Nerve Stimulation is more effective than unilateral Posterior Tibial Nerve Stimulation at treating overactive bladder and urge urinary incontinence
- Trial name
- BUTTON (NCT03535857)
- Testing
- PTNS
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Gnankang Sarah Napoe
Overactive Bladder
Evaluation of the The Neuromodulation System for the Treatment of Overactive Bladder Symptoms
To evaluate the efficacy and safety of non-invasive tibial nerve stimulator for the treatment of overactive bladder under the premise of ensuring the safety of the subjects and ensuring the scientific nature of the clinical…
- Trial name
- NCT04999657
- Testing
- Non-invasive low-frequency tibial nerve stimulator (TNS-01)
- Where
- 7 sites in China
- Volunteers
- 109 people
- Sponsor
- Medtecx Co Ltd.
Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI)
Clinical Utility of a PCR Compared to Culture and Sensitivity Testing for the Management of cUTI in Adults.
Complicated urinary tract infections (cUTIs) often lead to the overuse of empiric antibiotics, risking inappropriate treatment and contributing to antimicrobial resistance.
- Conditions
- Urinary Tract Infection Complicated, Urinary Tract Infection (cUTI), Urinary Tract Infection (Diagnosis)
- Trial name
- PCR (NCT06996301)
- Testing
- Treatment guided by the PCR results, Treatment guided by the C&S results
- Where
- 6 sites in United States
- Volunteers
- 773 people
- Sponsor
- Doc Lab Inc
Pregnancy, Malaria
Safe Pregnancy by Infectious Disease Control
Malaria and sexually transmitted infections (STIs) are common in pregnant women in Africa and are important preventable causes of poor birth outcomes and maternal and infant mortality.
- Trial name
- NCT00489619
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 2,008 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Non-Small Cell Lung Cancer, Small Cell Lung Cancer
QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors
QUILT-3.055 is a Phase 2b, open-label, multicohort study investigating combination immunotherapies in patients with advanced solid tumors who have previously been treated with PD-1/PD-L1 checkpoint inhibitors.
- Conditions
- Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Urothelial Carcinoma, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT03228667
- Testing
- N-803 + Pembrolizumab, N-803 + Nivolumab, N-803 + Atezolizumab
- Where
- 35 sites in United States
- Volunteers
- 40 people
- Sponsor
- ImmunityBio, Inc.
Preterm
Effects of Non-Traumatic Nasopharyngeal Suction Technique in Infants
Background: Non-invasive ventilation (NIV) in preterm infants often leads to secretion-related airway obstructions, requiring suctioning.
- Trial name
- NCT07111611
- Testing
- Non-Traumatic Nasopharyngeal Suction Procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
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