Clinical trials: Pathophysiology
Mild Cognitive Impairment
Mindfulness for Older Adults With Cognitive Concerns
The current study will examine the effects of a brief mindfulness based intervention (BMBI) on mood, memory and attention in comparison to a wait-list control (WLC) group.
- Trial name
- NCT02902692
- Testing
- Brief Mindfulness
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- King's College London
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery.
- Trial name
- NCT01103752
- Testing
- no intervention, descriptive study
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Lene Krenk
Cognitive Disorder
Assessment of the Need to Use Short Cognitive Tests for French General Practitioners/Family Doctors
The prevalence of cognitive disorders is constantly increasing, with 1.2 million patients affected in France in 2016. Dementia is currently the seventh leading cause of death.
- Trial name
- NCT06437847
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Sepsis
Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis
Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ…
- Trial name
- NCT02605681
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Cystic Fibrosis (CF), Cystic Fibrosis-related Diabetes
A CFit Study - Baseline
A great medical success is the increase in the median survival age associated with cystic fibrosis (CF). However, this success has led to a new era of research with the aim to maximise the quality of life (QoL) of the aging CF…
- Trial name
- NCT03234387
- Testing
- No intervention - only assessments.
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Mild Cognitive Impairment, Cognitive Impairment
Study of Nasal Insulin to Fight Forgetfulness - Device Study
The SNIFF Device study will involve using a device to administer insulin through each participant's nose or intra-nasally. Insulin is a hormone that is produced in the body.
- Trial name
- NCT03857321
- Testing
- Insulin, intranasal nebulizer-like device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Meibomian Gland Dysfunction
The Impact of Dry Eye Syndrome on Metrics of Low Contrast Vision Before and After Meibomian Gland Expression
The study aims to determine the impact of Meibomian Gland Dysfunction (MGD) dry eye on low contrast black/white (luminance) and cone color sensitivity performance and improvement in these functions after in-house non-invasive…
- Trial name
- NCT05713981
- Testing
- Meibomian gland (MG) expression
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of the Incarnate Word
Adropin In Patients of OSA
Serum Adropin as an Indicator of Endothelial Dysfunction and Disease Severity in Obstructive Sleep Apnea in Obese Patients
1. Objectives (Aim): To evaluate the role of serum adropin as a potential biomarker of endothelial dysfunction in OSA 1. Compare serum adropin levels between Obese patients with and without OSA. 2.
- Trial name
- NCT07829809
- Testing
- Adropin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aswan University
Diabetes Mellitus, Type 2
Mechanisms of Endothelial Dysfunction in Type 2 Diabetes
Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes.
- Trial name
- DIAB-EETs (NCT02311075)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Schizophrenia
Tryptophan-Kynurenine Pathway Metabolism in the Pathophysiology of Cognitive Impairment in Schizophrenia.
Schizophrenia is a common, long-term mental illness. It causes problems with thoughts, feelings, and behavior, including positive symptoms (hallucinations, delusions), negative symptoms (lack of emotion, motivation), and…
- Trial name
- NCT07162467
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Cancer-related Problem/Condition, Sexuality
The Find Your PATHS (Pragmatic Assessment of a Tool to Help Survivors) to Sexual Health and Parenthood Study
Concerns with sexual health and fertility are common among cancer patients, survivors and their partners. Literature reviews suggest that over 60% of survivors have reproductive health problems yet fewer than 20% get professional…
- Conditions
- Cancer-related Problem/Condition, Sexuality, Fertility
- Trial name
- PATHS (NCT03345264)
- Testing
- Online, interactive self-help program
- Where
- United States
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Chronic Granulomatous Disease
Effect of IFN-γ on Innate Immune Cells
The investigators hypothesize that neutrophils and monocytes developed under the influence of Interferon- gamma-1b (IFN-γ-1b, Actimmune*) in vivo will display enhanced function across a broad range of activities related in large…
- Trial name
- NCT02609932
- Testing
- Administration of drug (Interferon-gamma 1-b) subcutaneously
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Amino Acid, Stunting, Environmental Enteric Dysfunction
The Efficacy of Amino Acid Supplementation in Treating Environmental Enteric Dysfunction Among Children At Risk of Malnutrition
A randomised controlled open label clinical trial to determine whether addition of indispensable amino acids (IAA) to standard complementary food will reduce occurrence of Environmental Enteric Dysfunction (EED) compared with…
- Trial name
- NCT06617130
- Testing
- Corn soy bean blended flour porridge plus indispensable amino acid
- Where
- Malawi
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kamuzu University of Health Sciences
Cognitive Decline, Cognitive Symptoms
Oral Vitamin B12 Supplementation and Cognitive Performance in Elderly People
The purpose of this trial is to study the effects of oral vitamin B12 supplementation and vitamin B12 combined with folic acid supplementation on cognitive performance for 24 weeks in elderly people with mild vitamin B12…
- Trial name
- NCT00111267
- Testing
- vitamin B12 supplementation, vitamin B12 + folic acid combined supplementation
- Where
- Netherlands
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Cognitive Dysfunction, Low Back Pain
Frequency of Cognitive Dysfunction in Patients With Chronic Low Back Pain
This study evaluates cognitive dysfunction status and related factors in patients with chronic low back pain over the age of 60.
- Trial name
- NCT06278467
- Testing
- visual pain scale (VASpain/fatigue), Beck depression index (BDI),, Pain catastrophizing scale, sleep quality with a single Likert type question in the Pittsburgh questionnaire, Roland Morris Disability Questionnaire, quality of life with Short Form-36 ( SF-36),
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Konya Beyhekim Training and Research Hospital
Liver Cirrhoses, Peripheral Neuropathy
Electrophysiological Evaluation of Motor Dysfunction in Liver Cirrhotic Patients
cross sectional observational study, aimed to assess the electrophysiological function of the motor units in liver cirrhotic patients.
- Trial name
- NCT04340999
- Testing
- Nerve conduction studies and Quantitative EMG ( MUNE and IPA)
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Postoperative Cognitive Dysfunction
Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin
Data on prevention of perioperative neurocognitive disorders (pNCDs) are limited. The purpose of this monocentric parallel - grouped observational registry is to collect study data from studies with pNCDs as primary or secondary…
- Trial name
- NCT02832193
- Where
- 2 sites in Germany
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Memory Deficits, Aging
The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and…
- Conditions
- Memory Deficits, Aging, Cognitive Impairment, Physical Activity
- Trial name
- NCT05363228
- Testing
- Therapy by Dance and Movement, Tai Chi
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Women Health, Physiotherapy
Pelvic Floor Physiotherapy Combined With Sexual Therapy in Vaginismus Treatment
Studies on pelvic floor physiotherapy in individuals diagnosed with vaginismus are quite limited in the literature. While current studies have focused on certain physiotherapy modalities, the literature is quite limited in terms…
- Conditions
- Women Health, Physiotherapy, Exercise
- Trial name
- NCT06760767
- Testing
- sexual therapy, Pelvic floor physiotherapy combined with sexual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medipol University
Urinary Incontinence, Anal Incontinence
Tridimensional Pelvic Floor Ultrasound and Quality of Life Scores Questionnaires in Nulliparous or Parous Women
Evaluation of the impact of the delivery in the system of suspension and sustentation of pelvic floor, by 3D ultrasound and quality of life questionnaires.nt
- Conditions
- Urinary Incontinence, Anal Incontinence, Sexual Dysfunction, Self Esteem
- Trial name
- NCT03656601
- Testing
- 3D pelvic ultrasound
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
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