Clinical trials: Pathophysiology
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Endothelial Dysfunction and Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the role of endothelial dysfunction in chronic obstructive pulmonary disease.
- Trial name
- NCT02092675
- Where
- Croatia
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Andrea Vukic Dugac
Mild Cognitive Impairment
Water-based Activity to Enhance Recall in Veterans
This two-year study will evaluate the feasibility of an exercise training augmentation for cognitive training intervention to improve memory performance in Veterans with a diagnosis of amnestic Mild Cognitive Impairment (aMCI).
- Trial name
- WATER-VET (NCT02614092)
- Testing
- Water-based Activity + Cognitive Training
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Non-Alcoholic Fatty Liver Disease, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Probiotics (P. Pentosaceus, L. Lactis or L. Helveticus) in NASH
A study for evaluating the improvement effect on Metabolic dysfunction-associated steatotic liver disease (MASLD) of probiotics Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with dysbiosis of the…
- Trial name
- NCT04555434
- Testing
- Probiotics
- Where
- South Korea
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Periodontitis
Periodontal Infection and Endothelial Dysfunction
The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease
- Trial name
- NCT00681564
- Testing
- One-Stage Full-Mouth Disinfection, Periodontal care
- Where
- 2 sites in Colombia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Vertigo, Dizziness
Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo
Western University of Health Sciences is seeking men and women to participate in a study on the effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in patients with vertigo.
- Conditions
- Vertigo, Dizziness, Benign Paroxysmal Positional Vertigo, Labyrinthitis
- Trial name
- NCT01529151
- Testing
- Osteopathic Manipulative Treatment (OMT), Vestibular Rehabilitation Therapy (VRT)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Western University of Health Sciences
Mild Cognitive Impairment
Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease
This is a single center imaging study that will recruit 60 participants who are enrolled in the Effect of a Ketogenic Diet on Alzheimer's Disease Biomarkers and Symptoms: Brain Energy for Amyloid Transformation in AD (BEAT-AD)…
- Trial name
- AcAc PET (NCT03130036)
- Testing
- [11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Myelomeningocele, Neurogenic Bladder
Efficacy of Contrast Enhanced Voiding Urosonography for Urodynamic Studies
The investigators will assess the feasibility of replacing fluoroscopy/iodinated contrast with ultrasound/sulfur hexafluoride lipid-type A microspheres during routine urodynamic studies.
- Conditions
- Myelomeningocele, Neurogenic Bladder, Tethered Cord Syndrome, Bladder, Neurogenic
- Trial name
- NCT04738539
- Testing
- Contrast Enhanced Voiding Urosonography with Urodynamic Testing, Urodynamic Testing
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Duchenne Muscular Dystrophy
Evaluation of Brain Dysfunction in Patients with Duchene Muscular Dystrophy
To study the cognitive function \& psychiatric aspects of patients with DMD by specific psychometry tests \& its relation to quality of life of the patients To evaluate brain structural changes using MRI and correlate them to the…
- Trial name
- NCT06732011
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bipolar Disorder, Bipolar Depression
PET and MRI Brain Imaging of Bipolar Disorder
The primary aims of this study are to: 1. Quantify serotonin transporter (5-HTT) binding potential (BP) in vivo in bipolar disorder patients (BPD) during a major depressive episode (MDE). 2.
- Conditions
- Bipolar Disorder, Bipolar Depression, Unipolar Depression
- Trial name
- NCT01880957
- Testing
- Lithium, Lamotrigine
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Metabolic Dysfunction-Associated Steatotic Liver Disease, Fatty Liver
Samsung S-Viscosity vs Canon Dispersion Slope in Steatotic Liver Disease (SAVID-SLD)
Steatotic liver disease (SLD) is one of the most common chronic liver diseases worldwide. Distinguishing simple steatosis from metabolic dysfunction-associated steatohepatitis (MASH) with significant fibrosis is clinically…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Fatty Liver, Liver Fibrosis
- Trial name
- SAVID-SLD (NCT07530419)
- Testing
- Samsung Medison HERA W12 (R30) with S-Shearwave platform, Canon Aplio i800 with Dispersion Slope Imaging
- Where
- South Korea
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diastolic Dysfunction, Neonatal Encephalopathy
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography
The goal of this single-centre longitudinal observational study is to create reference values for diastolic function parameters in neonates born at 35 weeks' gestation or above, and to assess the influence of pre-defined…
- Conditions
- Diastolic Dysfunction, Neonatal Encephalopathy, Small for Gestational Age at Delivery, Transient Tachypnea of the Newborn
- Trial name
- DiFuSE (NCT06200519)
- Where
- Ireland
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University College Cork
Alzheimer Disease, Mild Cognitive Impairment
Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects
The primary objective of this study is to demonstrate that individuals with low short-term practice effects (STPE) on cognitive testing are more likely to be identified as "positive" on amyloid imaging than individuals with high…
- Trial name
- APPE (NCT03466736)
- Testing
- [18F]flutemetamol PET scan
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Utah
Prediabetes, Obesity
Effects of Antidiabetic Medications on the Postprandial State in Prediabetes
This project addresses cardiovascular disease risk in patients with prediabetes. Levels of lipids after eating a meal ("postprandial lipids") are strong independent predictors of cardiovascular risk.
- Trial name
- NCT02104739
- Testing
- Exenatide, Saxagliptin, Exenatide extended-release (ER)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Fatigue Syndrome, Cognitive Impairments
Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome
Over the past decade, the Rochester Center for Behavioral Medicine (RCBM) has evaluated many patients with attention deficit hyperactivity disorder (ADHD).
- Trial name
- NCT01071044
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rochester Center for Behavioral Medicine
Coronary Microvascular Disease, Microvascular Disease
Hyperoxia and Microvascular Dysfunction
Coronary artery disease (CAD) pathophysiology involves endothelium-dependent (e.g. nitric oxide, acetylcholine) and -independent (e.g.
- Conditions
- Coronary Microvascular Disease, Microvascular Disease, Ischemic Heart Disease
- Trial name
- NCT04321434
- Testing
- Hyperoxia, Normoxia, laser Doppler
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Laryngospasm, Hypoxemia
Prevention and Treatment of Laryngospasm and Hypoxemia Based on Risk Factors in Adult Outpatients Undergoing EGD
The purpose of this study is to identify patient and provider-chosen factors that put patients at risk for the development of hypoxemia (oxygen saturation < 90% for 5 seconds) during endoscopy and to use this knowledge to develop…
- Trial name
- NCT04159116
- Testing
- Prophylactic suctioning when clinically indicated
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Envision Healthcare Scientific Intelligence, Inc.
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Study on the Function of Taiwan Green Propolis in Reducing Blood Lipids and Body Fat in Sub-healthy Groups: MASLD
This study investigates the effectiveness of Taiwanese green propolis in reducing blood lipids and body fat in sub-healthy individuals.
- Trial name
- TGP (NCT07114926)
- Testing
- Taiwanese green propolis
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kuo,HSIN-YU
Mild Cognitive Impairment
Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment
This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training.
- Trial name
- NCT02559063
- Testing
- Vision-based speed of processing training, Mental leisure activities
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Stroke, Acute Ischemic, Cognitive Impairment
Effect of Preventive Cognitive Training on Cognitive Impairment After Stroke in Acute Stage
Post-stroke cognitive impairment(PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for 6 months.
- Trial name
- NCT05648149
- Testing
- hierarchical multi-dimensional cognitive training scheme based on computer
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
RED S, Eating Disorders
Relative Energy Deficiency in Sports (REDs) in Swedish Athletes
Background: Relative Energy Deficiency in Sport (REDs) describes impairment of health and performance due to problematic (long-term/severe) low energy availability (LEA), with or without eating disorders.
- Trial name
- REDs-Sweden (NCT06371963)
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
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