Clinical trials: Pathophysiology
Cognitive Decline, Cognitive Impairment
Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline
Serum 25(OH)D, dietary and supplemental vitamin D were shown to influence cognitive outcomes in large epidemiological studies. Sex/age-specific and race-specific associations of vitamin D status and intake were examined with…
- Trial name
- NCT03320109
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Erectile Dysfunction
Hemodynamic Study of Avanafil and Two α-Adrenergic Blockers,Doxazosin and Tamsulosin
The purpose of this study is to see if avanafil causes any changes in blood pressure and pulse rate when taken with doxazosin or tamsulosin.
- Trial name
- NCT01100021
- Testing
- Tamsulosin and avanafil, Doxazosin and avanafil
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Rheumatoid Arthritis, Insulin Resistance
Skeletal Muscle Dysfunction in Rheumatoid Arthritis (RA)
Muscle strength helps determine a person's quality of life and functional independence. Patients with rheumatoid arthritis often suffer from muscle weakness and a pre-diabetic condition called insulin resistance.
- Trial name
- NCT02535832
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Neck Disability, Back Disability
Chiropractic and Exercise Management of Spinal Dysfunction in Seniors
This study will compare the effectiveness of chiropractic and exercise treatment in the short- and long-term, when managing chronic neck and back disability in seniors over the age of 65 years.
- Trial name
- NCT01057706
- Testing
- chiropractic, exercise
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwestern Health Sciences University
Upper Extremity Dysfunction, Gait, Unsteady
The Effect of Improvement in Function on Foot Pressure, Balance and Gait in Children With Upper Extremity Affected
It has been shown that movements of the upper extremity during walking are associated with lower extremity mobility. For example, when walking at a slow pace, the swing frequency of the arms is 2: 1 compared to the legs, while…
- Conditions
- Upper Extremity Dysfunction, Gait, Unsteady, Juvenile Idiopathic Arthritis, Balance
- Trial name
- NCT04671524
- Testing
- Exercise protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
COVID-19 Pneumonia
A Novel Parameter LIT/N That Predicts Survival in COVID-19 ICU Patients
A brisk immune response can clear a pathogen but can cause extensive collateral damage to the host. It is known that coronavirus disease 2019 (COVID-19) infection triggers a multi system inflammatory disorder which can lead to a…
- Trial name
- NCT05520918
- Testing
- the LIT test
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Gazi University
Massage, Inflammatory Response
Comparison of Different Forms of Recovery on the Functionality After Physical Exercise
Delayed onset muscle soreness (DOMS) and decrease of musculoskeletal function are due to high intensity training and / or sports activities. These occur due to micro lesions of muscle tissue resulting in nociceptor sensitization.
- Conditions
- Massage, Inflammatory Response, Muscle, Skeletal, Cryotherapy Effect
- Trial name
- NCT04201977
- Testing
- Foam Roller Recovery, Active recovery, Immersion in cold water
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Sodium Excess
Dietary Sodium, Oxidative Stress, and Pulsatile Hemodynamics
High sodium diets impair vascular function, which may influence the work of the heart. This investigation is designed to determine if this change in vascular function results in a greater workload in the heart and if people who…
- Trial name
- NCT04233957
- Testing
- High Sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Gestational Diabetes Mellitus
The Role of Pregnancy-induced Gallbladder Dysmotility in the Pathophysiology of Gestational Diabetes Mellitus
The primary aim of the study is to evaluate postprandial gallbladder emptying and plasma concentrations of the glucose-lowering and satiety-promoting gut hormone glucagon-like peptide 1 (GLP-1) during third trimester of pregnancy…
- Trial name
- NCT04108065
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Syncope, Blood Injury Phobia
fMRI in Blood Phobia Syncope
We plan to study patient who faint in response to the sight of blood and compare them to healthy subjects who do not. We are going to use a special type of MRI scan (functional MRI) to determine if there are differences in brain…
- Conditions
- Syncope, Blood Injury Phobia, Autonomic Dysfunction
- Trial name
- NCT00715065
- Testing
- fMRI Scan
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University
Metabolic Syndrome, Vascular Compliance
Orange Juice, Hesperidin and Their Role in Vascular Health Benefit
Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to…
- Conditions
- Metabolic Syndrome, Vascular Compliance, Predisposition to Cardiovascular Disease
- Trial name
- HESPER-HEALTH (NCT04731987)
- Testing
- Beverage consumption
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Subjects
Benfotiamine Prevents Vascular Dysfunction in Healthy Smokers
Benfotiamine pretreatment (3 days)at high dosage (1050 mg/day) prevents in healthy subjects smoking-induced vascular dysfunction assessed by ultrasound flow mediated dilatation of the brachial artery.
- Trial name
- NCT00785460
- Testing
- Benfotiamine
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Delayed Graft Function
Can Fat Derived Stem Cells (SVF) be Used in the Treatment of Erectile Dysfunction After Prostatectomy
Prostate cancer is the most common cancer among Danish men, and the incidence is increasing. Studies have shown a high number needed to treat for each saved prostate cancer related death.
- Trial name
- NCT02240823
- Testing
- adipose derived stem cells
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Martha Haahr M.D
Stroke, Walking, Difficulty
Turning Dysfunction After Stroke: Assessment and Intervention
The study aims to investigate the 1) differences between stroke patients and healthy controls in time, steps, angular velocity, stepping patterns, electromyographic responses during turning, and the association of turning to…
- Conditions
- Stroke, Walking, Difficulty, Balancing Interference
- Trial name
- NCT04668573
- Testing
- Trunk exercise
- Where
- Taiwan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis
PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.
- Trial name
- NCT02247622
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Mild Cognitive Impairment, Traumatic Brain Injury
Neuromodulation and fMRI in Neurodegenerative Diseases Study
In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states.
- Conditions
- Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration
- Trial name
- NCT06873750
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Dementia, Cognitive Decline
Investigating Neurocognitive Disorders Epidemiology
This is a prospective cohort study with the main purpose of predicting progression neurocognitive disorders in Thai population. The main predictor variables to be evaluated are plasma phosphorylated tau (p-tau) level and…
- Conditions
- Dementia, Cognitive Decline, Alzheimer Disease
- Trial name
- INDE (NCT06375213)
- Testing
- Plasma tau phosphorylated at Thr217, Neurocognitive examination
- Where
- Thailand
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
MASLD, HIV (Human Immunodeficiency Virus)
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV
Metabolic dysfunction-associated steatotic liver disease (MASLD), commonly known as fatty liver disease, is increasingly prevalent worldwide.
- Trial name
- MASLD (NCT07640880)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yinzhong Shen
Blood Brain Barrier, Alzheimer Disease
The Relevance of the Blood-brain Barrier to Cognitive Dysfunction and Alzheimer's Disease
This study attempts to replicate the findings published in Nature Medicine by Nation and colleagues (2019). By using a large observational cohort (DZNE - Longitudinal Cognitive Impairment and Dementia Study; DELCODE) consisting…
- Conditions
- Blood Brain Barrier, Alzheimer Disease, Cognitive Dysfunction, Dementia
- Trial name
- NCT04093882
- Testing
- Contrast agent enhanced MRI using Gadovist
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
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