Clinical trials: Pathophysiology
Sacroiliac Disorder
Muscle Energy Technique on Sacroiliac Dysfunction
Sacroiliac pain is a huge problem in women during pregnancy and postpartum period. Muscle energy technique has potential effect in decreasing the pain and disability
- Trial name
- NCT05088837
- Testing
- muscle energy technique, ice and heat packs
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urinary Incontinence
Use of Sildenafil for Treatment of Urinary Incontinence
The investigators goal is to develop medical treatments for stress/mixed urinary incontinence. Sildenafil has been shown to improve blood flow as well as muscle mass and strength and to decrease muscle fatigue.
- Trial name
- NCT02983461
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pulmonary Disease, Chronic Obstructive, Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) and Osteoporosis
The main objective is to study important factors in the patho-physiology of osteoporosis in patients with COPD. Therefore, the investigators will study biological markers in plasma and urine and correlate them to markers of bone…
- Trial name
- NCT01067248
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Temporomandibular Joint Disorders, Temporomandibular Sprain
Intra-articular Magnesium Sulfate for Tmj Dysfunction
mixing the magnesium sulfate with dextrose for management of tmj pain will be studied using intra-articular injection of the solution
- Trial name
- NCT03675659
- Testing
- intra-articular injection
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Liver Diseases, Hepatic Insufficiency
A Pharmacokinetic Study of Baricitinib in Participants With Liver Disease
The main purpose of this study is to measure how much of the study drug called baricitinib gets into the blood stream and how long it takes the body to get rid of it. Healthy participants and those with liver disease may enroll.
- Trial name
- NCT01870388
- Testing
- Baricitinib
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Stroke, Stroke (CVA) or TIA
The Imperial Comprehensive Cognitive Assessment in Cerebrovascular Disease (IC3)
Stroke is a major cause of death and disability worldwide, frequently resulting in persistent cognitive deficits among survivors.
- Conditions
- Stroke, Stroke (CVA) or TIA, Dementia, Vascular, Cerebrovascular Disorders
- Trial name
- IC3 (NCT05885295)
- Testing
- MRI brain, Blood tests, cognitive assessments
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Mild Cognitive Impairment, Caregiver Burden
A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI
This clinical trial is being conducted to see if brain stimulation and brain training together improves cognitive functioning and mood in older adults diagnosed with Mild Cognitive Impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Caregiver Burden, Mental Health Issue, ADL
- Trial name
- rTMS+iVCT (NCT06024473)
- Testing
- rTMS, rTMS+iVCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System
Anesthesia, Cognitive Dysfunction
Evaluation of Cognitive Functions by Cerebral Pulse Oximetry
General and Spinal Anesthesia can be used in geriatric patients in orthopedic surgery. Post-op cognitive dysfunction can be seen in orthopedic surgeries in this group of patients.
- Trial name
- NCT03827083
- Testing
- cerebral pulse oximetry
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Alzheimer Disease, Dementia
Predictors of Cognitive Decline in Normal Aging
The goal of this project is to develop an early diagnostic test for Alzheimer's disease (AD) by monitoring loss of neurons and brain size reductions over a period of five years.
- Trial name
- NCT00094939
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Postoperative Cognitive Dysfunction
Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery
To investigate the effect of ultrasound-guided thoracic paravertebral nerve block combined with intraoperative infusion of s-ketamine on postoperative acute pain and cognitive function in patients with thoracoscopic surgery
- Trial name
- NCT05341375
- Testing
- Thoracic paravertebral block, Esketamine, Measurement of cognitive function
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Qinhuangdao
Septic Shock
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA
Purpose and rationale: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major public health problems killing one in every three patients.
- Trial name
- SshOCTA (NCT04593212)
- Testing
- Optical Coherence Tomography Angiography
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital da Luz, Portugal
Vaginal Discharge, Dyspareunia
Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort
Previous research has shown that semen deposition in the vagina after intercourse leads to dripping, discomfort, and vaginal odor.
- Conditions
- Vaginal Discharge, Dyspareunia, Female Sexual Dysfunction, Vaginitis
- Trial name
- NCT04885556
- Testing
- Tampon-like device for absorption of sexual fluids
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Myofascial Dysfunction
Immediate Effects of Upper Thoracic Manipulation on Skin Surface Temperature of T3 Vertebral Region and Biceps Brachii Muscle
The aim of the present study was to assess the immediate effects of upper thoracic manipulation on skin surface temperature in the region of the T3 vertebra and biceps brachii muscle in healthy women.
- Trial name
- NCT01872676
- Testing
- Spine manipulation
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Metodista de Piracicaba
Menopause, Blood Pressure
Effect of Different Exercise Modalities on Cardiovascular and Cognitive Response in Postmenopausal Women
Menopause is a natural stage in female aging, increasing cardiometabolic risk and making cardio-neuro-vascular disease (CNVD) the leading cause of mortality in women over 60.
- Conditions
- Menopause, Blood Pressure, Cognitive Decline
- Trial name
- WOMEN-EX-MOD (NCT06533982)
- Testing
- High intensity interval exercise session, Isometric neuromuscular exercise session
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Poitiers
Alzheimer's Disease, Mild Cognitive Impairment
Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease
This is a prospective cohort study for cognitively normal (young and old), mild cognitive impairment, and Alzheimer's disease people
- Trial name
- KBASE (NCT02137460)
- Where
- South Korea
- Volunteers
- 721 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Fibromyalgia (FM), Subclinical Ventricular Dysfunction
Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients With Fibromyalgia
Fibromyalgia (FM) is a chronic pain syndrome that affects multiple body systems and is often associated with fatigue, sleep disturbances, anxiety, and other comorbidities.
- Conditions
- Fibromyalgia (FM), Subclinical Ventricular Dysfunction, Myocardial Function
- Trial name
- GLS in FM (NCT07150455)
- Testing
- Echocardiographic Assessment (2D Speckle Tracking)
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Infantile Colic, Constipation - Functional
Bowel And Bladder Function in Infant Toilet Training
The overall purpose is to assess whether assisted infant toilet training during the first year of life can prevent functional gastrointestinal and urinary tract disorders up to 4 year of age.
- Conditions
- Infantile Colic, Constipation - Functional, Bladder Dysfunction, Toilet Training
- Trial name
- BABITT (NCT04082689)
- Testing
- Assisted Infant Toilet Training
- Where
- 6 sites in Sweden
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- Dalarna County Council, Sweden
Lower Extremity Lymphedema
Lipid Peroxidation and Options Antioxidant Therapy for Secondary Lymphedema of the Lower Extremities
A single-center, open, prospective, randomized, controlled clinical trial will include 120 patients with lower limb lymphedema who undergo treatment in an office-based vascular lab at the Ryazan regional clinical cardiology…
- Trial name
- NCT04360889
- Testing
- Micronised purified flavonoid fraction (diosmin+flavonoids expressed as hesperidin), Tocopherol, Elastic compression
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University
Gastrointestinal Dysfunction, Physiological Stress
Impact of Yogurt on Gastrointestinal Health, Regularity, and Thoughts
This study aims to test the central hypothesis that adding to the diet daily yogurt provides beneficial effects on digestive health and subjective mood in healthy adults.
- Conditions
- Gastrointestinal Dysfunction, Physiological Stress, Cognition - Other
- Trial name
- IYOGHRT (NCT04901390)
- Testing
- Yogurt with B. lactis and added cane sugar
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Mild Cognitive Impairment, Dementia
An Imaging Study to Investigate the Distribution of GSK239512 in the Brain.
GSK239512 is being developed for the treatment of symptoms of cognitive impairment in many diseases. GSK239512 is a drug that binds to the Histamine 3 receptor (a protein) in the brain (receptor occupancy).
- Trial name
- NCT00474513
- Testing
- GSK239512
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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