Clinical trials: Pathophysiology
Cardiovascular Disease, Endothelial Dysfunction
Elucidation and Monitoring Postprandial Endothelial Function
The primary aim of this study is to evaluate the effect of a high fat challenge on several measures of endothelial function. The secondary aim of this study is to elucidate the mechanism of postprandial endothelial dysfunction…
- Trial name
- EMPEF (NCT00766623)
- Testing
- high fat meal, control meal
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Adverse Childhood Experiences, Vascular Dilatation
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function.
- Conditions
- Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance
- Trial name
- NCT06454344
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-i)
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Infertility, Male, Azoospermia
The Association of Gut Microbiota and Spermatogenic Dysfunction
This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata.
- Conditions
- Infertility, Male, Azoospermia, Oligozoospermia, Asthenozoospermia
- Trial name
- NCT05628987
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Mild Cognitive Impairment (MCI), Dementia Alzheimer Type
Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort
The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea.
- Conditions
- Mild Cognitive Impairment (MCI), Dementia Alzheimer Type, Chronic Pain, Depression - Major Depressive Disorder
- Trial name
- KoCoA cohort (NCT07485387)
- Where
- South Korea
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Korea University
Erectile Dysfunction
A Study in Erectile Dysfunction
The purpose of this study is to determine the day of onset of efficacy of tadalafil dosed once-a-day.
- Trial name
- NCT00833638
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Atherosclerosis Cardiovascular Disease, Metabolic Syndrome
Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health
This study aims to investigate the extent to which vegan or plant-based, omnivorous, and carnivore dietary patterns affect LDL aggregation susceptibility (the affinity for LDL cholesterol particles to clump together in the…
- Conditions
- Atherosclerosis Cardiovascular Disease, Metabolic Syndrome, Dyslipidaemia, Endothelial Dysfunction
- Trial name
- NCT07474233
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
SHOULDER DYSFUNCTION
Virtual Reality For Shoulder Dysfunction Post Neck Dissection Surgeries
The goal of this clinical trial study: is to determine the effect of Virtual reality on pain and function for shoulder dysfunction post neck dissection surgeries.
- Trial name
- NCT06257238
- Testing
- Fully immersive Head-Mounted Display Virtual Reality, Traditional Physical Therapy Program
- Where
- Egypt
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Cairo University
Executive Dysfunction, Mild Cognitive Impairment (MCI)
Feasibility Study of Mixed Reality Exergame on Performance and Cortical Outcomes
The executive dysfunctions are a problem in individuals with MCI which predict conversion to dementia and is positively related to physical activity level.
- Trial name
- NCT06843733
- Testing
- Mixed reality exergame, Education
- Where
- Thailand
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Coronavirus Disease 2019
Olfactory and Neurosensory Rehabilitation in COVID-19-related Olfactory Dysfunction
A combination of oral vitamin A (VitA) and intense aromatic chemosensory smell training (ST) by pulse aromatic stimulation will expedite the neurosensory recovery of olfaction in patients suffering from prolonged COVID-19-related…
- Trial name
- NCT04900415
- Testing
- Vitamin A, Electronic portable aromatic rehabilitation (EPAR) diffuser
- Where
- 2 sites in Hong Kong
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ivan FN Hung MD
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Meibomian Glands
Characterization of Signs and Symptoms of Participants With and Without Meibomian Gland Dysfunction
This is an exploratory study to evaluate endpoints used to characterize participants with and without meibomian gland dysfunction (MGD) and will evaluate the correlation between signs and symptoms of MGD.
- Trial name
- NCT01979887
- Testing
- Meibum Expression
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Allergan
Sexual Dysfunction
Statin Lowering Testosterone and Sexual Function
Statins may decrease serum testosterone levels via decreasing cholesterol. This longitudinal study detected the effects of rosuvastatin on free testosterone levels and sexual function in men with type 2 diabetes.
- Trial name
- NCT02612714
- Testing
- Rosuvastatin
- Where
- Taiwan
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Paget's Disease of Bone
Pathophysiology of Paget's Disease of Bone
Paget's disease of the bone is a skeletal disorder which results in increased and disorganized bone remodeling, leading to dense but fragile and expanding bones.
- Trial name
- NCT02802384
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Alzheimer Disease, Cognitive Impairment
CBB Satisfaction Survey
The Cogstate Brief Battery (CBB) is a computerized measure for cognitive screening that consists of four cognitive tasks to assess psychomotor function, attention, learning, and working memory, and provides an easy-to-interpret…
- Trial name
- NCT06496347
- Where
- Taiwan
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Cheng Sheng Chen
Spinal Cord Injury, Neurogenic Bowel Dysfunction
Artificial Int: Neurogenic Bowel Education in Spinal Cord Injury Patients
The aim of this study is to evaluate the effectiveness of patient education delivered through an artificial intelligence (AI)-based mobile application in the management of neurogenic bowel dysfunction in individuals with spinal…
- Trial name
- ArtInt (NCT07369349)
- Testing
- Mobil Application
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Senem Duman
Cognitive Impairment, Poor Nutrition
The PROtein Enriched MEDiterranean Diet and EXercise Trial for Older Adults At Risk of Undernutrition
PROMED-EX is a single-blind, parallel group randomised controlled trial to determine the effect of a PROtein enriched MEDiterranean diet (PROMED) in comparison to a PROtein enriched MEDiterranean diet and EXercise (PROMED-EX)…
- Conditions
- Cognitive Impairment, Poor Nutrition, Cognitive Decline
- Trial name
- PROMED-EX (NCT05166564)
- Testing
- A Protein Enriched Mediterranean Diet (PROMED) Intervention, A Protein Enriched Mediterranean Diet & Exercise (PROMED-EX) Intervention
- Where
- United Kingdom
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Parkinson Disease, Parkinsonism
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular "Powerhouse") Dysfunction
Parkinson's disease (PD) is a progressive neurological disorder that is increasingly common with age, with the incidence rising from approximately 4 people per 10,000 in their forties to 2 in 100 over the age of eighty.
- Trial name
- SysMedPD (NCT03421899)
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University College, London
Covid19, Angiogenesis
Endothelial Damage and Angiogenesis Biomarkers During COVID-19
Severe SARS-CoV-2 disease is characterized by a progressive hypoxemic respiratory failure. Autopsies from these patients show severe endothelial damage with extensive vascular thrombosis, microangiopathy, and occlusion of…
- Conditions
- Covid19, Angiogenesis, Endothelial Dysfunction, Cardiovascular Morbidity
- Trial name
- NCT04609332
- Testing
- Endothelial damage and angiogenic biomarkers
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Vestibular Diseases
2BALANCE: Cognitive-motor Dual-tasking in Persons with Vestibular Disorders
The overall aim of this study is to elucidate the impact of a vestibular dysfunction on the cognitive and motor performance by means of an extensive test protocol, evaluating the vestibular, cognitive and motor function using…
- Trial name
- NCT04126798
- Testing
- Behavioural
- Where
- Belgium
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cognitive Dysfunction
Integrative Therapy for Holistic, Natural Cognition and Lifestyle Rehabilitation
An observational study to determine outcomes of older adults who are under naturopathic medical care for cognitive complaints at a specific clinic in Southern California.
- Trial name
- ITHNCLR (NCT04284449)
- Testing
- Whole-practice cognitive optimization
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
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