Clinical trials: Pathophysiology
Middle Aged Patients
Effect of Intranasal Insulin on Postoperative Cognitive Dysfunction
Our study is designed to evaluate the effect of intranasal insulin on postoperative cognitive dysfunction. Primary outcome: 1. The occurrence of cognitive dysfunction at approximately 7 days after surgery. Secondary outcome: 1.
- Trial name
- NCT04154449
- Testing
- Intranasal insulin
- Where
- 2 sites in Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Minia University
Pediatric Obesity, Insulin Resistance
Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity
The main purpose of this study is to determine whether treatment with acarbose attenuates post-prandial glycemic excursions in non-diabetic/pre-diabetic obese children as determined by continuous glucose monitoring systems…
- Conditions
- Pediatric Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00846521
- Testing
- Acarbose
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Cognitive Dysfunction
Effects Of An 8-Weeks Mindfulness-based Intervention In Individuals With Subjective Cognitive Decline
The European Commission Horizon 2020 programme has funded the SCD-WELL trial to investigate the efficacy of mindfulness-based training to reduce anxiety in individuals with Subjective Cognitive Decline (SCD), in comparison to an…
- Trial name
- SCD-WELL (NCT03005652)
- Testing
- Mindfulness weekly courses for 8 weeks, Health education weekly courses for 8 weeks
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea
Sex Steroids, Sleep, and Metabolic Dysfunction in Women
Increased plasma triglyceride concentration is a common feature of the metabolic abnormalities associated with obesity and a major risk factor for cardiovascular disease.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Obstructive Sleep Apnea, Obesity
- Trial name
- SCOR (NCT00805207)
- Testing
- Progesterone, testosterone, glucocorticoid
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Vulvovaginal Atrophy, Urinary Incontinence
Combination of BTL-785F and HPM-6000UF Devices for Women's Intimate Wellness
The goal of this clinical trial is to evaluate the combined application of BTL-785F and HPM-6000UF Devices in improving quality of life in women with negative changes in the urogenital system (vulvovaginal atrophy symptoms…
- Conditions
- Vulvovaginal Atrophy, Urinary Incontinence, Sexual Dysfunction
- Trial name
- NCT06846216
- Testing
- Treatment with BTL-785F and HPM-6000UF Devices
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Mild Cognitive Impairment
Improvement of Memory in Mild Cognitive Impairment
The Clinical Trial will systematically examine the feasibility of remote, caregiver-led tACS for older adults with memory deficits and evaluate whether repeated tACS leads to sustained improvement of neuronal activity and memory…
- Trial name
- NCT05708001
- Testing
- transcranial alternating current stimulation (tACS), high-density electroencephalography (hdEEG), Montreal Cognitive Assessment (MoCA)
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Depression, Bipolar Disorder
Mitochondrial Dysfunction, Inflammation, and White Matter Integrity in Youth With Mood Disorders
This study consists of three separate appointments including a clinical assessment (interview and questionnaires), a blood draw, a social stress test, and a brain MRI.
- Conditions
- Depression, Bipolar Disorder, Bipolar Disorder Not Otherwise Specified, Unspecified Mood Disorder
- Trial name
- NCT02596698
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Mild Cognitive Impairment, Mild to Moderate Cognitive Impairment
Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease
The goal of this study is to create new retinal imaging processing software useful for the development of novel retinal biomarkers of cognitive impairment associated with Alzheimer's disease (AD).
- Trial name
- NCT01937221
- Testing
- spectral-domain optical coherence tomography (SD-OCT)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Fasting
Investigating the Effect of Short-term Fasting on T Cell Metabolism, Function, and Phenotype in Obesity
The immune system is made up of many types of immune cells, each of which play a specialized role in protecting against pathogens.
- Conditions
- Obesity, Fasting, T-Cell Dysfunction
- Trial name
- NCT05886738
- Testing
- Fasting
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Aging, Functional Disturbance
Home Support for Elderly: Evaluation of Intra- Extrinsic Determinants Which Maximize This Possibility
The French National Institute of Statistics and Economic Studies (INSEE) projects that the number of people aged 75 and over will increase in France from 5.2 million in 2007 to 11.6 million in 2060 (i.e., a 123% increase) and…
- Conditions
- Aging, Functional Disturbance, Home
- Trial name
- MADMAX (NCT06121778)
- Testing
- Home
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Mild Cognitive Impairment
Effectiveness of Tongue Resistance Exercises on Tongue and Swallowing Function in Frail Older Adults With MCI
The purpose of this study is to explore the effects of tongue resistance exercises on tongue muscle strength and swallowing function in frail older adults with mild cognitive impairment living in the community.
- Trial name
- NCT06766487
- Testing
- Tongue resistance exercises, cheek bulging exercises
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation
Left Ventricular Systolic Dysfunction, Healthy Volunteers
Multicenter Normal Reference Study of Tissue Motion Tracking of Mitral Annular Displacement(TMAD)
To establish the range of TMADmid、TMADmidpt% by using tissue motion tracking of mitral annular displacement (TMAD), and to explore the influencing factors.
- Trial name
- TMAD (NCT04399447)
- Testing
- Echocardiography
- Where
- 76 sites in China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Weidong Ren
Risk Behavior, Cognitive Decline
Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention
Alzheimer's Disease (AD) and other Dementias have far-reaching consequences on the lives of sufferers and their loved ones, not to mention the impact on the healthcare system.
- Trial name
- NCT06748625
- Testing
- Luci Coach-Assisted Intervention
- Where
- Canada
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- LuciLab
Depressive Disorder, Major, Cognitive Dysfunction
bWell-D Pilot Randomized Controlled Trial
The goal of this clinical trial is to determine the acceptability, feasibility, and validity of the bWell Cognitive Care Platform for Depression (bWell-D), a novel Virtual Reality (VR) cognitive assessment and remediation tool…
- Trial name
- NCT06546917
- Testing
- bWell Cognitive Remediation, VR Experience
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
End Stage Renal Disease and Cognitive Impairment
Blood-Brain Barrier Evaluation In Nephrology (BREIN)
Patients with Chronic Kidney Disease (CKD) have impaired psycho-cognitive functions in parallel with deteriorating kidney function.
- Trial name
- BREIN (NCT04328415)
- Testing
- Cerebral scintigraphy
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cognitive Impairment
Effect of Technology on Cognitive Function in Elderly
Cognitive technology therapies, including interactive video gaming, computer soft wares and mobile technology, have been used to implement cognitive training and rehabilitation programs.
- Trial name
- cogntion (NCT06378606)
- Testing
- cognitive therapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nourhan Hesham Ali
Mild Cognitive Impairment
Measuring the Impact of a Socially Assistive Robot
Due to increasing age and an increasing prevalence rate of neurocognitive disorders such as Mild Cognitive Impairment and dementia, independent living may become challenging.
- Trial name
- NCT04848155
- Testing
- socially assistive robot
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Ghent
Cognitive Decline, Mild Cognitive Impairment
The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults
This trial investigates the effect of a chicken extract supplement and a peptide supplement on cognitive function and potential mechanisms of action of cognitive decline during ageing, among non-demented elderly adults using a…
- Conditions
- Cognitive Decline, Mild Cognitive Impairment, Aging
- Trial name
- NCT04555655
- Testing
- Chicken extract supplement, Peptide Supplement
- Where
- 3 sites in Taiwan
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Brand's Suntory Asia
Hyper-Immunoglobulin E. Syndrome (HEIS), Chronic Granulomatous Disease (CGD)
Skin Immunity Sample Collection Involving Blisters and Biopsies
Background: The way the body heals and protects itself from getting sick is called the immune response. Some people with weak immune systems get sick often or get rashes and skin infections.
- Trial name
- NCT03921515
- Testing
- Blister induction, Skin Biopsies
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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