Clinical trials: Pathophysiology
Alzheimer's Disease
Safety and Efficacy of MEM 1003 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease
The purpose of this study is to determine in a 12-week treatment study if MEM 1003 is a safe and effective treatment for patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00257673
- Testing
- MEM 1003
- Where
- 57 sites in United States
- Volunteers
- 183 people
- Sponsor
- Memory Pharmaceuticals
Laryngospasm
Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children. To determine whether the co-administration of lidocaine blunts these reflex responses.
- Trial name
- LR6 (NCT01222169)
- Testing
- NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Thomas Erb
Hypertension
Treatment of Supine Hypertension in Autonomic Failure
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension.
- Trial name
- NCT00223717
- Testing
- Clonidine, Nitroglycerin transdermal, Dipyridamole/ Aspirin (Aggrenox)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Vanderbilt University
Spinal Dysraphism
Uronephrological Complications Risk Factors in Spinal Dysraphism
Spinal dysraphism consist of congenital malformations resulting of abnormalities in the formation of neural tube and/or surrounding structures during embryogenesis.
- Trial name
- RUD (NCT05718440)
- Testing
- Individualisation of uronephrological complications risk factors
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinal Nerve Fiber Layer Thickness, Chronic Kidney Disease
Retinal Protective Effects of Novel Finerenone in Patients With Chronic Kidney Disease
Interestingly, A hypothesis-generating analysis was conducted from two studies using routine ophthalmological examinations from clinical trial participants (ReFineDR/DeFineDR), suggesting a potential benefit of finerenone in the…
- Trial name
- NCT07235891
- Testing
- Finerenone
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Sacroiliac Joint Dysfunction
Muscle Energy Techniques and Sacral Manipulation on Pain, Functional Disability and Quality of Life
The study will be randomized clinical trial. This study will be conducted in University of Lahore Teaching Hospital, Lahore, Pakistan.
- Trial name
- NCT05018780
- Testing
- Muscle Energy Technique, Sacral Manipulation
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- University of Lahore
Coronary Artery Disease, HMG-CoA Reductase Inhibitor Toxicity
Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients
The present study constitutes a study examining the effect of atorvastatin on vascular function in high cardiovascular risk patients.
- Conditions
- Coronary Artery Disease, HMG-CoA Reductase Inhibitor Toxicity, Atherosclerosis, Oxidative Stress
- Trial name
- NCT01013103
- Testing
- Atorvastatin, high vs low dose
- Where
- Greece
- Volunteers
- 72 people
- Sponsor
- Hippocration General Hospital
Sexual Dysfunction, Stress Incontinence
A Study to Measure the Degree and Effectiveness of the Various vSculpt Operating Modes
A pilot study to determine the degree and effectiveness of the various modes of vSculpt, an over-the-counter "OTC" medical device, on enhanced genital blood flow and improvement in quality of life in menopausal women who suffer…
- Trial name
- NCT02856490
- Testing
- vSculpt, InTone
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Joylux, Inc.
Eustachian Tube Dysfunction
Tubomanometry and EarPopper Devices for Eustachian Tube Function Testing
The Eustachian tube (ET) is a biological tube that links the middle ear to the back of the nose and throat. It has several functions, of which the most important is to maintain optimal middle-ear health.
- Trial name
- NCT03850197
- Testing
- EarPopper, Tympanometry, Tubomanometry
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cuneyt M. Alper
Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder
Aβ PET and Tau PET Imaging in the Diagnosis and Progression Assessment of Alzheimer's Disease
This prospective study recruited 20 healthy volunteers and 50 patients diagnosed with Alzheimer's disease (AD) and mild cognitive impairment (MCI) according to clinical guidelines.
- Conditions
- Alzheimer Disease (AD), Cognitive Dysfunction, Cognitive Disorder, PET Imaging
- Trial name
- NCT07114224
- Testing
- AV45/AV-1、AV1451 PET
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Chronic Kidney Disease (Stages 4 and 5), Mild Cognitive Impairment (MCI)
Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems.
- Trial name
- Exprecoimp-CKD (NCT07160959)
- Testing
- Exercise, Control (Standard treatment)
- Where
- 6 sites in France, Italy and 4 more
- Volunteers
- 124 people
- Sponsor
- Biogem s.c.ar.l.
IgA Nephropathy, Membranous Nephropathy
IM19 CAR-T Cell Therapy for IgA Nephropathy Patients and Membranous Nephropathy Patients
IM19 CAR-T cell therapy for IgA nephropathy patients with urinary protein and renal dysfunction, as well as patients with intermediate to high-risk primary membranous nephropathy
- Trial name
- NCT06690359
- Testing
- IM19 chimeric antigen receptor T cell injection
- Volunteers
- 12 people
- Sponsor
- Beijing Immunochina Medical Science & Technology Co., Ltd.
Retinopathy, Diabetic, Diastolic Dysfunction
REWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes Mellitus
Retinopathy may be associated with diastolic dysfunction and/or coronary flow reserve in the heart, and albuminuria in diabetic patients.
- Conditions
- Retinopathy, Diabetic, Diastolic Dysfunction, Microalbuminuria
- Trial name
- NCT04025996
- Testing
- Cardiac Assessments and Eye Assessments
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Postoperative Cognitive Dysfunction
Effects of Brain Beta-Amyloid on Postoperative Cognition
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age.
- Trial name
- NCT01606488
- Testing
- Florbetapir F 18 (18F-AV-45), no intervention
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Organ Dysfunction, Organ Support
Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction
Acute pancreatitis may cause early respiratory, cardiovascular, or renal dysfunction and may require intensive care and organ support.
- Conditions
- Organ Dysfunction, Organ Support, Acute Pancreatitis (AP)
- Trial name
- TEA-APOD (NCT07697690)
- Testing
- Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia
- Volunteers
- 150 people
- Sponsor
- First People's Hospital of Chenzhou
Meibomian Gland Dysfunction
Efficacy of 0.05 % Cyclosporine Ophthalmic Emulsion Compare With Tear in Meibomian Gland Dysfunction
To evaluate the efficacy of 0.05% cyclosporine ophthalmic emulsion (Restasis® , Allergan) versus an artificial tears alone in patients with meibomian gland dysfunction that have abnormal tear quality and quantity by subjective…
- Trial name
- NCT00705510
- Testing
- 0.05% cyclosporin eye drop
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Mahidol University
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Long-lasting Bicarbonate-Sulfate-Calcium-Magnesium Water Intake on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Outcome
Background: Fonte Essenziale®, a mineral water rich in bicarbonate, sulphate, calcium, and magnesium, has shown potential in modulating the gut-liver axis and microbiota in hepatic steatosis.
- Trial name
- FonteESSEMASLD (NCT07211113)
- Testing
- Fonte Essenziale® mineral water
- Where
- Italy
- Volunteers
- 87 people
- Sponsor
- University of Campania Luigi Vanvitelli
Capillary Leak Syndrome
Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery
The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important.
- Trial name
- GLYNO (NCT02853682)
- Testing
- plasma
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Delirium, Postoperative Cognitive Dysfunction
Rivastigmine in the Treatment of Postoperative Delirium: a Pilot Clinical Trial
The purpose of this study is to determine whether preoperative administration of Rivastigmine prevents the incidence of postoperative delirium in patients undergoing major surgery as well as postoperative cognitive dysfunction.
- Trial name
- NCT00835159
- Testing
- Rivastigmine Patch
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
HIV, Endothelial Dysfunction
Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls
Our objective is to determine whether HIV infected youth have higher level of endothelial dysfunction, as measured by Peripheral Arterial Tonometry, when compared to age matched healthy controls.
- Trial name
- NCT02324179
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
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