Clinical trials: Pathophysiology
Microvascular Coronary Dysfunction, Microvascular Angina
Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study
The goal of this clinical trial is to assess the feasibility of undertaking a randomized controlled trial assessing the impact of a personalised, intense cardiac rehabilitation programme involving high intensity interval exercise…
- Conditions
- Microvascular Coronary Dysfunction, Microvascular Angina, Coronary Microvascular Dysfunction (CMD)
- Trial name
- MICROFIT (NCT06681896)
- Testing
- MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Obsessive-Compulsive Disorder
Understanding How Ketamine Brings About Rapid Improvement in OCD
The purpose of this study is to understand how ketamine brings about rapid improvement in Obsessive-Compulsive Disorder (OCD) symptoms.
- Trial name
- MKET (NCT02624596)
- Testing
- Ketamine, Midazolam
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia
RCT of tDCS Combined With Cognitive Training in Schizophrenia
Given the superior effects of CT augmented tDCS in healthy subjects, the aim of the current study was to examine whether the effect of CT on cognition can be enhanced with concurrent anodal tDCS in schizophrenia patients.
- Trial name
- NCT04870996
- Testing
- tDCS, Cognitive Training
- Where
- Hong Kong
- Volunteers
- 44 people
- Sponsor
- CHAN SAU MAN, SANDRA
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Erectile Dysfunction
Study to Assess the Efficacy and Safety of SK3530 on Erectile Dysfunction in Patients With Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of SK3530 on erectile dysfunction in Patients with Diabetes Mellitus.
- Trial name
- NCT00705861
- Testing
- SK3530
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- SK Chemicals Co., Ltd.
Syndrome X
Syndrome X and Endothelial Dysfunction
Cardiac syndrome X is characterized by angina, positve stress test, and patent coronary angiography, and its probable mechanism is microvascular dysfunction associated with endothelial dysfunction.
- Trial name
- NCT00190086
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Aortic Aneurysm, Gastrointestinal Dysfunction
Gastrointestinal Dysfunction in Aortic Surgery Patients
The goal of this observational study is to determine the association of gastrointestinal dysfunction through the Gastrointestinal Dysfunction Scale (GIDS) tool and serum concentrations of citrulline and Intestinal fatty-acid…
- Conditions
- Aortic Aneurysm, Gastrointestinal Dysfunction, Aortic Diseases, Enteral Feeding Intolerance
- Trial name
- NCT06514170
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 114 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Pelvic Organ Prolapse
Pelvic Floor Study: Biomechanical Properties of the Female Pelvic Floor
Pelvic floor dysfunction in the form of pelvic organ prolapse or urinary and fecal incontinence is a sequela for some women who experience injuries during birth. It affects adult women of all ages.
- Trial name
- NCT01042470
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- David Scheiner
Covid19
Impact of Adipose Tissue in COVID-19
Overweight or obese patients are particularly exposed to severe forms of COVID-19. Few data suggest that adipose tissue infected with SARS-CoV-2 could be involved in the onset of the cytokine storm seen in severe forms of…
- Trial name
- COVIFAT (NCT04639440)
- Testing
- Adipose tissue
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Cancer
Stabilizer Pressure Biofeedback on Neck Dysfunction
Fifty patients of both genders with age ranged from 30 - 50 years, suffering from neck dysfunction post neck dissection surgeries participated in this study.
- Trial name
- NCT07313189
- Testing
- Stabilizer pressure biofeedback plus traditional physical therapy, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Mild Cognitive Impairment, Frailty
Cognitive Frailty in Older Adults: The Role of Technology in Physical Activity Enhancement
This study intends to determine if smart watches and mobile phone application prompts can complement physical activity as a preventive intervention by motivating participants to exercise, so as to improve their physical and…
- Trial name
- NCT04692974
- Testing
- Mobile phone application and smart watch
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Older Adults, Depression
Educational and Cultural Engagement and Incidence of Health Adverse Events
This study evaluated if the social and cultural activities decrease the incidence of dementia and frailty conditions.
- Conditions
- Older Adults, Depression, Cognitive Decline
- Trial name
- NCT03987360
- Testing
- Observational
- Where
- Canada
- Volunteers
- 30,000 people
- Sponsor
- Jewish General Hospital
Mild Cognitive Impairment
Computer Games to Prevent Mild Cognitive Impairment and Dementia
The aim of the study is to show that regular playing with the logic games developed in the framework of the M3W (Mental Wellness Toolset) project (https://m3w-project.eu/) can prevent mild cognitive impairment (MCI) and dementia.
- Trial name
- NCT02310620
- Testing
- Cognitive training
- Where
- Hungary
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Cognitive Change, Cognitive Impairment
The Everyday Function Intervention Trial
Loss of independence, cognitive decline, and difficulties in everyday function are areas of great concern for older adults and their families.
- Conditions
- Cognitive Change, Cognitive Impairment, Healthy Aging, Dementia
- Trial name
- EFIT (NCT04651582)
- Testing
- Cognitive Training, Cognitive Stimulating Activities
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Clemson University
Critical Illness With or Without Sepsis
TRanscriptomic Analysis of Circulating Endothelial Cells During Sepsis - TRACES Study
Vascular dysfunction is an important mechanism involved in organ failure, in the setting of sepsis condition, with different types of circulating endothelial cells.Transcriptom analysis via RNAseq in different types of…
- Trial name
- TRACES (NCT04841824)
- Testing
- Observational study
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
MCI, Mild Cognitive Impairment
The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI)
The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for…
- Conditions
- MCI, Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- iPACES (NCT05009524)
- Testing
- iPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- iPACES LLC
Atrial Fibrillation, Heart Failure
A Mechanistic Exploratory Study of AF-induced Cardiac Dysfunction and Symptoms
Although the heart rhythm disorder Atrial Fibrillation (AF) affects 2% of the population, the impact it has on an effected individual can be highly variable.
- Trial name
- NCT04987723
- Testing
- Holter monitoring, stress echocardiography, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 106 people
- Sponsor
- Barts & The London NHS Trust
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Post-infective Bowel Dysfunction, Functional Gastrointestinal Disorders
Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates
The purpose of the study is explore the issues that relate to testing a particular dietary treatment, the low FODMAP diet, in a randomised trial using an appropriate control diet with which to compare it.
- Trial name
- CEDRIC (NCT02232373)
- Testing
- low FODMAP dietary advice, Maltodextrin, Oligofructose
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Nottingham
Malignant Neoplasm, Unspecified Adult Solid Tumor, Protocol Specific
Imatinib Mesylate in Treating Patients With Advanced Cancer and Kidney Failure
Phase I trial to determine the dose of imatinib mesylate that is most effective with the least amount of toxic side effects in treating patients who have advanced cancer and kidney failure.
- Trial name
- NCT00026169
- Testing
- imatinib mesylate, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- National Cancer Institute (NCI)
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