Clinical trials: Pathophysiology
Rectal Cancer, Rectosigmoid Cancer
Physical Activity in Rectal Cancer Survivors
The goal of this clinical trial is to test a telehealth-based personalized physical activity intervention in adult patients diagnosed with Stage I-III rectal cancer.
- Trial name
- NCT06435975
- Testing
- Physical Activity, Survey, Telehealth Lifestyle Coaching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Insufficiency;Cardiac, Cancer
Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment
New therapies for cancer increased patient survival, but led to the recognition of adverse effects associated with cancer treatment, such as the use of chemotherapy.
- Conditions
- Insufficiency;Cardiac, Cancer, Cardiotoxicity, Heart Failure
- Trial name
- NCT04047901
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Female Infertility, Polycystic Ovary Syndrome
Evaluation of Clinical Outcomes and Costs of a Lifestyle Intervention in Obese Infertile Women
BACKGROUND: Obesity increases the risk of polycystic ovary syndrome (PCOS), characterized by anovulatory cycles, but it is also associated with reduced fertility even in ovulatory women.
- Conditions
- Female Infertility, Polycystic Ovary Syndrome, Obesity
- Trial name
- OF (NCT01483612)
- Testing
- Interdisciplinary lifestyle intervention
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Université de Sherbrooke
Cognitive Impairment, Cognitive Decline
Personalized Virtual Reality Naturalistic Scenarios in Cognitive Impairment
The goal of this feasibility study is to investigate the feasibility of a personalized naturalistic Virtual Reality scenario by assessing motion-sickness effects, engagement, pleasantness, and emotions felt considering a sample…
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognitive Deterioration, Anxiety State
- Trial name
- NCT05863065
- Testing
- Exposure to a Virtual Reality scenarios
- Where
- 2 sites in Italy
- Volunteers
- 23 people
- Sponsor
- University of Padova
Mild Cognitive Impairment, Alzheimer's Disease
Home-Based Assessment for Alzheimer Disease Prevention
The purpose of this study is to evaluate three methods of performing home-based assessments in Alzheimer's Disease (AD) prevention trials. The initial in-person assessment will be done in the clinic or at home.
- Trial name
- HBA (NCT00546767)
- Testing
- Mail and Live Phone, Interactive Voice Response (IVR), Home-based Computer Kiosk
- Where
- 28 sites in United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Osteoarthritis, Knee Arthritis
Mechanism of IL-10 Pathway-mediated Regulatory B Cell Dysfunction in Osteoarthritis
Our previous work has shown that Treg function is impaired in OA patients, but the cause of Treg deficiency has not been investigated.
- Trial name
- NCT06227195
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shufeng Li
2D Speckle Tracking Echocardiography, Breast Cancer
Role of Multi-modality Imaging in the Assessment of Chemotherapy Related Cardiac Dysfunction Among Cancer Patients
The field of oncology has advanced remarkably. Some of the old and new emerging cancer therapies are associated with development of cardiovascular toxicities , which may have the potential to offset the gains in survival obtained…
- Conditions
- 2D Speckle Tracking Echocardiography, Breast Cancer, Cardiac Magnetic Resonance
- Trial name
- NCT06206395
- Testing
- Two dimensions speckle tracking and three dimension echocardiography and cardiac magnetic resonance imaging
- Where
- Egypt
- Volunteers
- 190 people
- Sponsor
- Assiut University
Dementia, Cognitive Impairment
Implementation and Evaluation of Improved Access to Medical Imaging for Geriatric Patients of The Royal Ottawa Hospital
In this study, the investigators implement FDG-PET imaging for clients in the Geriatric Psychiatry department at The Royal Ottawa Hospital (ROH) and evaluate the impact of this advanced imaging technique on client care.
- Conditions
- Dementia, Cognitive Impairment, Dementia With Lewy Bodies
- Trial name
- NCT05428475
- Testing
- [18F]FDG-PET Scan
- Volunteers
- 15 people
- Sponsor
- Tim Lau
Velopharyngeal Insufficiency, Head and Neck Cancer
Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study
Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), a problem with closure between the soft palate and throat that can cause nasal-sounding speech, food or liquid leaking into the nose, difficulty…
- Conditions
- Velopharyngeal Insufficiency, Head and Neck Cancer, Survivorship, Dysphagia
- Trial name
- NCT07264036
- Testing
- Pharyngeal Wall Augmentation Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanessa Torrecillas
Alzheimer's Disease, Mild Cognitive Impairment
Evolution of Memory Related Activity
The purpose of this study is to begin the process of validating fMRI (functional magnetic resonance imaging) as a biomarker for use in clinical trials and longitudinal studies of clinical progression in mild cognitive impairment…
- Trial name
- NCT00902499
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Gynecologic Cancer, Sexual Dysfunction
Sexual Dysfunction in Gynecologic Oncology Patients
This project will evaluate sexual dysfunction in women who have had surgery for gynecologic cancer. The subjects will complete a set of questionnaires about health, daily living, sexual encounters, and pain before their surgery…
- Trial name
- NCT03801031
- Testing
- Lidocaine Topical
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- David Bender
Insomnia, Cognitive Disorder
Study on Cognitive Impairment of Insomnia Based on MRI
Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment.
- Conditions
- Insomnia, Cognitive Disorder, MRI
- Trial name
- NCT05659511
- Testing
- MRI
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Depressive Disorder, Cognitive Impairment
Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder
In this project, the efficacy of different tDCS protocols in major depression will be investigated. The tDCS protocols have already been investigated in humans, and results showed that stimulation intensity has a different effect…
- Conditions
- Depressive Disorder, Cognitive Impairment, Psychiatric Disorder
- Trial name
- NCT06165445
- Testing
- transcranial direct current stimulation (tDCS), multichannel transcranial direct current stimulation (tDCS)
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Right Ventricular Dysfunction
Right Ventricular Function Changes After CIED Implantation: The RIGHT-CIED Study
This study aims to understand how the right side of the heart changes in people who receive an implantable cardiac electronic device (CIED), such as a pacemaker, ICD, or CRT device.
- Trial name
- RIGHT-CIED (NCT07272395)
- Testing
- Multimodal Right Ventricular Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Inner Ear Disease, Equilibrium; Disorder, Labyrinth
Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation.
Motor control includes postural control and voluntary movement. For an optimal motor control it is necessary that brain integrates vestibular, visual and somatosensorial inputs properly, in a nonlinear way.
- Conditions
- Inner Ear Disease, Equilibrium; Disorder, Labyrinth, Spatial Navigation
- Trial name
- NCT03171181
- Testing
- Vestibular reeducation
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Schizophrenia, Treatment Resistant Schizophrenia
Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia
Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention/vigilance.
- Conditions
- Schizophrenia, Treatment Resistant Schizophrenia, Cognitive Impairment
- Trial name
- TRACE (NCT07404319)
- Testing
- Aerobic Exercise, Stretching/Education Control, Active tDCS
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Kit Wa Chan
Surgery, Laparoscopic, Sexual Dysfunction, Physiological
Bowel, Urinary and Sexual Function After Laparoscopic Colorectal Surgery
Research Populations: Male patients scheduled for laparoscopic colorectal surgery Study Method: Questionnaire and function tests Hypothesis: A laparoscopic nerve-sparing operation is not inferior to reported open surgery in…
- Conditions
- Surgery, Laparoscopic, Sexual Dysfunction, Physiological, Colorectal Surgery
- Trial name
- NCT00451165
- Testing
- laparoscopic colorectal surgery
- Where
- Japan
- Volunteers
- 36 people
- Sponsor
- Kyoto University
Endothelial Dysfunction
Effects of Krill Oil on Intestinal Integrity Markers in Elite Rowers.
The study aims to check the influence of krill oil on markers of intestinal injury and intoxication. Research group: the research will be conducted in a homogeneous group of professional rowers (N=30), all competitors qualified…
- Trial name
- NCT06271434
- Testing
- THYROX (Atlantic krill oil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Female Sexual Dysfunction
PK Study of Testosterone Nasal Gel (TBS-2) in Healthy Premenopausal Women
The purpose of this study was to assess the bioavailability of total testosterone through pharmacokinetic profiles obtained following (a) single administration of three doses of TBS-2 b) multiple administration TBS-2.
- Trial name
- NCT01364623
- Testing
- Low dose testosterone nasal gel, single dose, Medium dose testosterone nasal gel, single dose, High dose testosterone nasal gel, single dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Acerus Pharmaceuticals Corporation
Heart; Surgery, Heart, Functional Disturbance as Result
The Role of Modified Ultrafiltration Following Open Heart Surgery
This study aims to investigate the effect of combining conventional ultrafiltration and modified ultrafiltration compared to conventional ultrafiltration alone in patients who underwent open heart surgery.
- Trial name
- NCT06085066
- Testing
- Conventional Ultrafiltration alone on Cardiopulmonary bypass, Conventional Ultrafiltration followed by Modified Ultrafitration on Cardiopulmonary bypass
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Indonesia
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