Clinical trials: Patient Reported Outcome
Oncology, Glioma
Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma
Patients with IDH-mutant glioma frequently experience symptoms such as fatigue, seizures, headaches, cognitive impairments (primarily attentional), and mood changes, which can significantly affect their health-related quality of…
- Trial name
- NEURO-PRO-GLIO (NCT07439302)
- Testing
- Neurocognitive assessment, Questionnaries QoL, Resilience Pro Application
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea (OSA), Sleep Apnea Syndrome, Obstructive
Empagliflozin and CPAP in Adults With Heart Failure and Obstructive Sleep Apnea.
The goal of this randomized clinical trial was to evaluate the effects of empagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i) on sleep and cardiac outcomes in adults with heart failure (HF) and obstructive sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Sleep Apnea Syndrome, Obstructive, Heart Failure
- Trial name
- HF(L)OSA (NCT07556094)
- Testing
- Empagliflozin, Continuous Positive Airway Pressure (CPAP)
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Bialystok
HER2-positive Breast Cancer
Real World Patient-Reported Outcomes in Chinese Her2+ EBC Patients Receiving (Neo) Adjuvant Anti-Her2 Based Therapy
This is a non-interventional observational, multi-center cohort study to evaluate patient-reported outcomes in Chinese HER2+ early breast cancer patients undergoing (neo) adjuvant anti-HER2 based therapy and describe changes over…
- Trial name
- NCT06161922
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Fudan University
Hypertrophic Cardiomyopathy (HCM)
COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM)
COLLIGO-HCM is a global observational study that will conduct observational research of hypertrophic cardiomyopathy (HCM) treatment in real-world clinical practice.
- Trial name
- COLLIGO-HCM (NCT06372457)
- Testing
- Approved Hypertrophic Cardiomyopathy drug treatments, Mavacamten
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis, Polyarthritis
Construct Validity and Responsiveness of EQ-5D-3L in Patients With Rheumatic Disease
The aim of this study is to investigate the construct validity (convergent and known-groups) and responsiveness of EQ-5D-3L in patients with rheumatoid arthritis, polyarthritis, psoriatic arthritis, and ankylosing spondylitis.
- Conditions
- Rheumatoid Arthritis, Polyarthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT06568029
- Testing
- Questionnaire
- Where
- Sweden
- Volunteers
- 77,651 people
- Sponsor
- Karolinska Institutet
Premature Ejaculation
IX-01 Effect on Intravaginal Ejaculatory Latency Time (IELT) and Patient Reported Outcomes in Men With Premature Ejaculation (PE)
The purpose of this study is to determine the effectiveness of IX-01 in men with lifelong premature ejaculation.
- Trial name
- NCT02232425
- Testing
- IX-01
- Where
- 10 sites in United States, Australia
- Volunteers
- 88 people
- Sponsor
- Ixchelsis Limited
Diagnosis of Cancer
Eortc MoBilE Device (EMBED)
This study is a longitudinal observational study that will investigate the feasibility of using mobile devices for the assessment of HRQoL and physical activity in adult cancer patients undergoing treatment.
- Trial name
- EMBED (NCT07711080)
- Volunteers
- 137 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Musculoskeletal Injuries
Pre- and Post-neuromusculoskeletal Injury Risk Evaluation for Return-to-Duty Enhancement
The purpose of this study is to develop comprehensive and efficient pre- and post- musculoskeletal injury (MSKI) risk assessments for Service members, incorporating both objective and subjective measures.
- Trial name
- PREPARE (NCT05111925)
- Testing
- PREPARE Initial Clinical Assessment - Pilot (two iterations), PREPARE Initial Clinical Assessment - Pre-Injury (one iteration), PREPARE Initial Clinical Assessment - Post-Injury (up to three iterations)
- Where
- 2 sites in United States
- Volunteers
- 2,690 people, healthy volunteers welcome
- Sponsor
- Womack Army Medical Center
Breast Cancer, Breast Neoplasms, Breast Reconstruction
Evaluation of Wellbeing and Patient Reported Outcomes After Open vs Robotic Mastectomy With DIEP Reconstruction
Nipple-sparing mastectomy (NSM) preserves the nipple-areolar complex (NAC) and is associated with improved cosmetic outcomes, body image, and patient satisfaction compared with more ablative techniques.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Reconstruction, DIEP Flap Breast Reconstruction, Robotic Surgery
- Trial name
- REBORN (NCT07230535)
- Testing
- Robotic Assisted Nipple Sparing Mastectomy, Standarding Open Nipple Sparing Mastectomy
- Where
- Ireland
- Volunteers
- 250 people
- Sponsor
- Beaumont Hospital
Total Hip Arthroplasty
Cemented Acetabular Cups Clinical Study
This clinical study has the aim to evaluate clinical, radiographic, patient-reported outcomes of total hip arthroplasty with the implant of Mueller cemented acetabular cups up to 2 years after surgery, in order to assess the…
- Trial name
- NCT04831918
- Testing
- Mueller cemented cups
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Limacorporate S.p.a
Rheumatoid Arthritis
The Effect of Certolizumab Pegol on MRI Synovitis and Bone Edema in Rheumatoid Arthritis Patients
The purpose of this study is to determine whether Certolizumab pegol can rapidly reduce the inflammatory changes and inhibit erosions on hand and wrist MRI in patients with active moderate to severe rheumatoid arthritis.
- Trial name
- PICS (NCT01213017)
- Testing
- certolizumab pegol
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Oklahoma Medical Research Foundation
Dental Implantation, Postoperative Pain
Patient-reported Outcome Measures Comparing Static Computer-aided Implant Surgery and Conventional Implant Surgery
The aim of this randomized controlled trial was to compare PROMs in patients receiving single tooth replacement in posterior sites by s-CAIS and CIS.
- Conditions
- Dental Implantation, Postoperative Pain, Computer-assisted Surgery, Patient Outcome Assessment
- Trial name
- NCT04950491
- Testing
- Modified Dental Anxiety Score (MDAS) questionnaire, Pain questionnaire, Oral Health-Related Quality of Life (OHRQoL) questionnaire
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dental Implant, Primary Sjögren Syndrome
Prognosis of Dental Implants in Patients With Primary Sjögren's Syndrome
Primary Sjögren's Syndrome (PSS) is a chronic autoimmune inflammatory disease primarily involving the salivary and lacrimal glands. Few data exist regarding survival and success rate of dental implants in patients with PSS.
- Trial name
- NCT04960605
- Testing
- Dental implants
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Non Small Cell Lung Cancer (NSCLC)
Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO
To assess the impact of prophylactic treatment on the incidence of adverse events in advanced NSCLC patients (post chemotherapy) treated with dacomitinib daily as a single agent.
- Trial name
- ARCHER 1042 (NCT01465802)
- Testing
- Dacomitinib, Doxycycline, Probiotic
- Where
- 81 sites in United States, South Korea
- Volunteers
- 236 people
- Sponsor
- Pfizer
Obesity, Morbid Obesity
Comparing Dumping Symptoms and Quality of Life 6 Months After Sleeve Gastrectomy With or Without Transit Bipartition in Adults With Obesity
This clinical study aims to compare two types of bariatric (weight loss) surgery used to treat obesity: sleeve gastrectomy alone and sleeve gastrectomy with transit bipartition.
- Conditions
- Obesity, Morbid Obesity, Dumping Syndrome, Postgastrectomy Syndrome
- Trial name
- STuD-QoL (NCT07263269)
- Testing
- Sleeve Gastrectomy, Sleeve Gastrectomy with Transit Bipartition
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mina Kamal Gergis Erian
Total Knee Arthroplasty, Regional Anesthesia
Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty
This trial aims to assess the analgesic effect of Popliteal Plexus Block (PPB) with 10 mL versus 20 mL of Bupivacain 5 mg/mL, when applied as an adjunct treatment to a multimodal analgesic regimen following primary total knee…
- Conditions
- Total Knee Arthroplasty, Regional Anesthesia, Multimodal Analgesic Approach, Postoperative Opioid-related Complications
- Trial name
- NCT06908837
- Testing
- Bupivacaine
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Regionshospitalet Silkeborg
Sarcoma
Burden and Medical Care of Sarcoma in Germany
The main objective of the study is to assess the treatment situation of sarcoma patients in Germany and to investigate their potential influence on Quality of Life (and other Patient Reported Outcomes) of the affected persons.
- Trial name
- PROSa (NCT03521531)
- Where
- Germany
- Volunteers
- 1,309 people
- Sponsor
- Technische Universität Dresden
Foot Diseases, Ankle Disease
Estimation of the Minimal Important Difference and Validation of Foot and Ankle Instruments
The present study investigates the minimal important change and validity of foot and ankle measures.
- Trial name
- NCT03444441
- Testing
- Foot or ankle surgery
- Where
- 4 sites in Finland
- Volunteers
- 290 people
- Sponsor
- Helsinki University Central Hospital
Inflammatory Bowel Diseases
Validation Study for Disability Assessment Functional of Patients With Inflammatory Diseases Intestinal Chronic (VALIDate)
Inflammatory Bowel Diseases (IBD) often affect psychological, family, social and professional dimensions of patients' life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (PROs) newly…
- Trial name
- VALIDate (NCT03590639)
- Where
- 3 sites in France
- Volunteers
- 400 people
- Sponsor
- Nantes University Hospital
Multiple Sclerosis
Comparison of Brain Atrophy Rates, Cognition, and Patient-Reported Outcomes in MS Patients Using Long-term Fingolimod and Glatiramer Acetate
Rates of brain atrophy for long term users of fingolimod when compared to glatiramer acetate have not been examined in patients with relapsing forms of multiple sclerosis (MS).
- Trial name
- NCT02307877
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- University of Colorado, Denver
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