Clinical trials: Patient With Prolonged Mechanical Ventilation
Weaning Failure
The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function
While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in…
- Trial name
- NCT04758910
- Testing
- High Flow Oxygen Therapy, T-piece
- Volunteers
- 30 people
- Sponsor
- Evangelismos Hospital
High Flow Oxygen Therapy
Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the…
- Trial name
- NCT06357390
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Effect of Methadone on the Duration on Mechanical Ventilation
Impact of Methadone on Prolonged Mechanical Ventilation in Patients on Continuous Treatment With Opioids
The purpose of this study is to determine the effect of methadone on the duration on mechanical ventilation in critically ill patients receiving more than 72 hours of mechanical ventilation (MV) by comparing the number of…
- Trial name
- IMPACTOR (NCT06110546)
- Testing
- Methadone group, Usual care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Patient After Cardiac Valve Surgery, Patient With Prolonged Mechanical Ventilation
The Association Between Intestinal Perfusion and Prolonged Mechanical Ventilation in Patients After Cardiac Valve Surgery
Background This study aimed to confirm that alterations in Doppler parameters of superior mesenteric artery(SMA) blood flow caused by intestinal hypoperfusion are associated with prolonged mechanical ventilation(PMV) in patients…
- Trial name
- NCT05500495
- Testing
- no intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
PICS
Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation
Past research on PICS has mainly focused on the predictability and prognosis of PICS occurrence in ICU patients. Still, there is currently insufficient research on the role of PICS in the care setting of patients who have…
- Trial name
- NCT07002710
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Prolonged Mechanical Ventilation, Protein Deficiency
High Protein, Core Muscle Rehab, Muscular Electrostimulation in Prolonged Mechanical Ventilation
The goal of this clinical trial is to learn about in patients with prolong mechanical ventilation. This main questions aims to answer are: High protein formula intake benefit in successful weaning from ventilator Core muscle…
- Trial name
- NCT05932134
- Testing
- UC + high protein diet (HP), UC + HP + core muscle rehabilitation, UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Respiratory Insufficiency, Wounds and Injuries
Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation
This study compares the effects of two primary airway humidification methods-active heated humidifiers (HHs) and passive heat-and-moisture exchangers (HMEs)-on trauma intensive care unit (ICU) patients requiring prolonged…
- Conditions
- Respiratory Insufficiency, Wounds and Injuries, Critical Illness
- Trial name
- NCT07713238
- Testing
- Airway Humidification Device
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Patients With Postoperative Mechanical Ventilation After Liver Transplantation
Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation
Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively.
- Trial name
- NCT02402634
- Testing
- Mechanical ventilatory lung care
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Yonsei University
PMV
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function
The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean.
- Trial name
- NCT05295381
- Testing
- cough machine (CM), abdominal weight training (AWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Liu Shih Feng
Prolonged Mechanical Ventilation
Diaphragm Dysfunction During Prolonged Mechanical Ventilation
The transition to unassisted breathing after invasive ventilation often proves challenging. Persistent ventilator dependence predisposes patients to nosocomial complications and death and increases the economic burden of critical…
- Trial name
- DD-SRPR (NCT03676998)
- Testing
- Measurement of diaphragm function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation, Covid19
Mortality in Patients With Severe COVID-19 Pneumonia Who Underwent Tracheostomy
Background: Invasive mechanical ventilation (IMV) in COVID-19 patients has been associated with a high mortality rate. In this context, the utility of tracheostomy has been questioned in this group of ill patients.
- Conditions
- Mechanical Ventilation, Covid19, Tracheostomy
- Trial name
- NCT04642703
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- University of Chile
Mechanical Ventilation
Clinical Application of the Effect of Respiratory Muscles Electrical Stimulation on Weaning in Patients With Difficult Weaning of the Mechanical Ventilation
This trial evaluates whether transcutaneous diaphragmatic/phrenic nerve stimulation (TEDS), abdominal functional electrical stimulation (abFES), or their combination, accelerates and improves the quality of weaning from prolonged…
- Trial name
- NCT07199036
- Testing
- TEDS (Transcutaneous Diaphragmatic/Phrenic Nerve Stimulation), abFES (Functional Electrical Stimulation of Abdominal Muscles)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Surrogate Decision Makers, Prolonged Mechanical Ventilation
Improving Decision Making for Patients With Prolonged Mechanical Ventilation
Deciding about prolonged life support for critically ill patients can be very difficult. Therefore, the investigators are doing a study to see if an internet-based decision aid can improve the quality of decision making for…
- Trial name
- NCT01751061
- Testing
- Decision aid, Usual care
- Where
- 4 sites in United States
- Volunteers
- 416 people
- Sponsor
- Duke University
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital
Anxiety, Prolonged Mechanical Ventilation
Effects of Music Therapy on Anxiety Symptoms in Patients With Prolonged Mechanical Ventilation: A Randomized Controlled Trial
The purpose of this study is to evaluate the effects of music therapy on anxiety symptoms in patients requiring prolonged mechanical ventilation (PMV).
- Trial name
- NCT07560384
- Testing
- Patient-Directed Music Therapy (PDMT), Environmental Control and Matched Interaction
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Respiratory Failure, Respiration, Artificial
Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode.
- Trial name
- NCT04140682
- Testing
- PAV+ mode, PSV mode
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
Respiratory Failure
Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
Muscle atrophy and diaphragm dysfunction are common complication in patients with prolong mechanical ventilator (PMV) and is associated with increased rate of weaning failure and days of hospitalization.
- Trial name
- NCT02227810
- Testing
- electrical stimulation (high frequency), electrical stimulation (low frequency)
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- Chang Gung Memorial Hospital
Wounds and Injuries, Ventilation Therapy; Complications
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
Critically ill patients often require tracheal intubation for mechanical ventilation, and timely weaning is crucial for airway management and reducing complications.
- Trial name
- NCT06339073
- Testing
- mechanical ventilation
- Where
- China
- Volunteers
- 1,023 people
- Sponsor
- Jinling Hospital, China
Nosocomial Infections
Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation
Nosocomial infection with antibiotic-resistant strains is a major threat to critical care medicine. Selective decontamination of the digestive tract (SDD) is one of the strategies to reduce ventilator associated pneumonia and…
- Trial name
- LFasSDD (NCT01535170)
- Testing
- bovine Lactoferrin
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- China Medical University Hospital