Clinical trials: Patient With Schizophrenia Spectrum Disorder
Schizophrenia, Schizophreniform Disorders
Sodium Benzoate and/or N-Acetylcysteine Added to TAU in Patients With Early Schizophrenia Spectrum Disorder.
This study aims to determine if the addition of Sodium Benzoate and / or NAC to TAU will be acceptable and tolerable and result in overall improvement of symptoms, social and cognitive functioning in patients with early…
- Conditions
- Schizophrenia, Schizophreniform Disorders, Schizoaffective Disorder
- Trial name
- NCT03510741
- Testing
- Sodium Benzoate, N-Acetylcysteine, Sodium Benzoate Plus N-Acetylcysteine
- Where
- 5 sites in Pakistan
- Volunteers
- 64 people
- Sponsor
- Pakistan Institute of Living and Learning
Schizophrenia
A Long-Term Safety Study of Pomaglumetad Methionil in Schizophrenia
The purpose of this study is to evaluate the long-term safety of pomaglumetad methionil in participants with schizophrenia.
- Trial name
- NCT01487083
- Testing
- Pomaglumetad methionil
- Where
- 51 sites in United States, Austria and 9 more
- Volunteers
- 129 people
- Sponsor
- Denovo Biopharma LLC
Schizophrenia
The Effect of a Community-based LAT-treated Management Model on the Violence Risk of Patients With Schizophrenia
This is a 49 weeks open-label randomized controlled study. Patients with schizophrenia and violence risk will be enrolled in the study.
- Trial name
- NCT03434210
- Testing
- LAT-treated Community Model, care as usual
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Yi Li MD, PhD
Schizophrenia, Cognitive Deficits
Augmentation of Working Memory Training With Transcranial Direct Current Stimulation in Patients With Schizophrenia
Cognitive impairment is a core symptom of schizophrenia and is in a large part responsible for the poor psychosocial outcome of the disorder.
- Trial name
- NCT03621540
- Testing
- active tDCS, Adaptive working memory training
- Where
- 2 sites in Germany
- Volunteers
- 37 people
- Sponsor
- University Hospital Tuebingen
Schizophrenia
Tolerability, Safety and Efficacy of Flexibly Dosed Paliperidone ER in Patients With Schizophrenia
The purpose of this study is to evaluate efficacy, safety and tolerability of flexible, once-daily doses of paliperidone extended-release (ER) in patients with schizophrenia from Argentina and Colombia that previously failed…
- Trial name
- PERFLEX (NCT01724359)
- Testing
- Paliperidone ER
- Where
- 5 sites in Argentina, Colombia
- Volunteers
- 95 people
- Sponsor
- Janssen-Cilag, S.A.
Schizophrenia
Seroquel® Combined With Cognitive Remediation Therapy to Conventional Treatment in Patients With Schizophrenia
The purpose of this study is to compare efficacy of quetiapine fumarate combined with Cognitive Remediation Therapy (CRT) to conventional treatment by evaluating change in social outcome in patients with schizophrenia.
- Trial name
- SCORE (NCT00255515)
- Testing
- Quetiapine fumarate, conventional treatment for schizophrenia
- Where
- 15 sites in Sweden
- Volunteers
- 85 people
- Sponsor
- AstraZeneca
Schizophrenia, Schizoaffective Disorder
Raloxifene Augmentation in Patients With a Schizophrenia Spectrum Disorder
There is increasing clinical and molecular evidence for the role of hormones and specifically estrogen and its receptor in schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder, Psychosis NOS
- Trial name
- RAPSODI (NCT03043820)
- Testing
- Raloxifene
- Where
- Netherlands
- Volunteers
- 110 people
- Sponsor
- Iris Sommer
Schizophrenia
A Study of RO4917838 (Bitopertin) in Patients With Sub-optimally Controlled Symptoms of Schizophrenia (WN25306)
This randomized, multi-center, double-blind, parallel-group, placebo-controlled study will evaluate the efficacy and safety of RO4917838 (bitopertin) in patients with sub-optimally controlled symptoms of schizophrenia.
- Trial name
- NCT01235585
- Testing
- bitopertin [RO4917838]
- Where
- 120 sites in United States, Brazil and 12 more
- Volunteers
- 597 people
- Sponsor
- Hoffmann-La Roche
Patient Treated With Lithium, With Bipolar or Schizo-affective Disorder, Hospitalized in a Psychiatric Ward
Validation of the French Version of the Lithium Knowledge Test (LKT)
Lithium is a drug used to treat several psychiatric illnesses. This medication requires particular vigilance because it has a narrow therapeutic margin: the dose necessary to obtain an effective treatment is close to the toxic…
- Trial name
- LKT (NCT06033326)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Lille
Schizophrenia
Safety, Tolerability and Pharmacokinetics of AUT00206 in Patients With Schizophrenia, and Also Explores the Effects of AUT00206 on Relevant Central Biomarkers.
This study will investigate the safety, tolerability, PK and PD profile of AUT00206 after repeated doses in patients with stable but symptomatic schizophrenia, taking one or two established anti-psychotic drugs.
- Trial name
- NCT03164876
- Testing
- AUT00206
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Autifony Therapeutics Limited
Schizophrenia
Cerebellar rTMS for the Treatment of Schizophrenic Patients
The primary aim of this protocol is to determine whether the use of repetitive transcranial magnetic stimulation (rTMS) over vermis of the cerebellum may be safe and therapeutically effective in patients with schizophrenia.
- Trial name
- NCT01072617
- Testing
- Transcranial magnetic stimulation via MagPro x100 device
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Mental Illness, Major Depression
My Coach Connect: An Automated Telephone-based Reporting System for Patients With Mental Illness
This is a pilot study for a novel, automated telephone system called "My Coach Connect". The purpose of the study is to evaluate the feasibility and effectiveness of this telephone tool while engaging clients and providers in…
- Conditions
- Chronic Mental Illness, Major Depression, Schizophrenia, Bipolar Disorder
- Trial name
- MCC (NCT01749124)
- Testing
- My Coach Connect
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- RAND
Schizophrenia, Metabolic Syndrome
Prevalence of Metabolic Syndrome in Patients With Schizophrenia in Korea
The aim of this study is to examine the prevalence of the Metabolic syndrome(MetS) in Korean patients with schizophrenia. Primary objective: To investigate the prevalence of the MetS in Korean patients with schizophrenia…
- Trial name
- NCT01477918
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Asan Medical Center
Schizophrenia, Schizophrenia; Psychosis
A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2)
This is a Phase 3, randomized, double-blind, parallel-group, placebo-controlled, multicenter inpatient study to examine the efficacy and safety of KarXT in adult subjects who are acutely psychotic with a Diagnostic and…
- Trial name
- NCT04659161
- Testing
- Xanomeline and Trospium Chloride Capsules
- Where
- 22 sites in United States
- Volunteers
- 252 people
- Sponsor
- Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Schizophrenia, Cognitive Impairment
Study of ALTO-101 in Patients With Schizophrenia
This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition.
- Trial name
- NCT06502964
- Testing
- ALTO-101, ALTO-101 Transdermal Delivery System
- Where
- 14 sites in United States
- Volunteers
- 82 people
- Sponsor
- Alto Neuroscience
Schizophenia Disorder, Interventional Study
Interventional Programs' Impact on Patients' Quality of Life and Functioning
The objective of the study is to investigate the effect of interventional program in improving the quality of life for individuals with chronic schizophrenia The design of the study will be an interventional study - Randomized…
- Trial name
- NCT06715553
- Testing
- BALANCE Program (Body, Art, Learning, Activities, Nutrition, Creativity, and Education)
- Where
- Lebanon
- Volunteers
- 86 people
- Sponsor
- Psychiatric Hospital of the Cross
Schizophrenia
Study to Evaluate the Efficacy and Safety of Risperidone ISM® in Patients With Acute Schizophrenia: Open Label Extension
This is the long-term open label extension (OLE) of the study PRISMA-3 (NCT03160521). Those patients who complete participation in the main segment of the study (double blind) together with other clinically stable not previously…
- Trial name
- PRISMA-3_OLE (NCT03870880)
- Testing
- Risperidone ISM 75 mg, Risperidone ISM 100 mg
- Where
- 24 sites in United States, Ukraine
- Volunteers
- 215 people
- Sponsor
- Rovi Pharmaceuticals Laboratories
Schizophrenia
Auditory Verbal Hallucinations in Schizophrenia
Auditory verbal hallucinations (AVHs) are speech perceptions in the absence of a relevant external stimulation. Some accounts of AVHs claim that a deficit in inner speech monitoring would cause the verbal thoughts of the patient…
- Trial name
- HAV (NCT01886417)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Bipolar Disorder
Physician Survey on Monitoring of Patients Treated With Quetiapine
A physician survey to document receipt of metabolic educational materials and assess behavior of physicians in following messages communicated through the educational materials
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT01795326
- Volunteers
- 800 people
- Sponsor
- AstraZeneca
Schizophrenia
Study of the Efficacy and Safety of Quetiapine Fumarate Extended Release (Seroquel XR)
This is an 8-week, multi-centre, Open-label, non-comparative study to evaluate the efficacy and safety of Quetiapine XR with daily dose 400mg-800mg used as mono-therapy in the treatment of acute schizophrenic patients.
- Trial name
- QUENCH (NCT00779506)
- Testing
- Quetiapine Fumarate XR
- Where
- 7 sites in South Korea
- Volunteers
- 96 people
- Sponsor
- AstraZeneca
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