Clinical trials: Patient With Schizophrenia Spectrum Disorder
Schizophrenia
A Study of LY2140023 in Patients With Schizophrenia
The purpose of this study is to determine whether at least 1 dose level of LY2140023 given to acutely ill patients with schizophrenia will demonstrate significantly greater efficacy as compared to placebo.
- Trial name
- NCT01307800
- Testing
- LY2140023
- Where
- 13 sites in United States, Mexico and 3 more
- Volunteers
- 567 people
- Sponsor
- Denovo Biopharma LLC
Schizophrenia
Cognitive and Emotional Factors in Visual Exploration Among Patients With Schizophrenia
Background: Patients with schizophrenia are abnormally disturbed by information onsets, which may result in a disadvantage in filtering relevant information.
- Trial name
- SAILLANCE1 (NCT02874482)
- Where
- France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Schizophrenia, Schizoaffective Disorder
Cognitive Skills Training Using Computer for Patients With Severe Mental Illness
The study is designed to evaluate the effectiveness of computerized cognitive skills training for improving memory and problem-solving skills in inpatients with schizophrenia.
- Trial name
- NCT01036282
- Testing
- Computerized Cognitive Skill Training, CRT and Social Cognition
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Acute Psychotic Episode, Schizophrenia Spectrum and Other Psychotic Disorders
Copeptin in Outcome Prediction of an Acute Psychotic Episode
An acute psychotic episode is a severe psychiatric syndrome which might occur in different psychiatric diagnoses. The outcome prediction of relapse rate of a psychotic episode within a certain time frame is difficult and depends…
- Conditions
- Acute Psychotic Episode, Schizophrenia Spectrum and Other Psychotic Disorders, Affective Disorder, Bipolar Disorder
- Trial name
- CoPsych (NCT03235908)
- Testing
- Observation only
- Where
- Switzerland
- Volunteers
- 73 people
- Sponsor
- University Hospital, Basel, Switzerland
Sexual Dysfunction, Hyperprolactinemia
A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders
This trial designed to investigate the effect of switching to aripiprazole from risperidone or paliperidone on reverse prolactin level, and consequently improve sexual dysfunction in adult patients with schizophrenia spectrum…
- Trial name
- NCT01742390
- Testing
- Aripiprazole, risperidone or paliperidone
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Si Tianmei
Schizophrenia
Randomized, Double-blind, Placebo Controlled, Multi-center and Tolerability of RBP-7000 in Schizophrenia Patients
The purpose of this study is to evaluate the efficacy and safety of RBP-7000 compared with placebo in the treatment of patients with schizophrenia.
- Trial name
- NCT02109562
- Testing
- RBP-7000, Risperidone
- Where
- 32 sites in United States
- Volunteers
- 354 people
- Sponsor
- Indivior Inc.
Schizophrenia
Supported Employment and Skills Training in Conjunction With Pharmacotherapy in Schizophrenia Patients
This study will compare employment support with behavioral skills training to employment support alone in schizophrenia patients taking either risperidone or olanzapine to determine which is more effective in helping the patients…
- Trial name
- NCT00183625
- Testing
- Individual Placement and Support (Supported Employment), Social Skills Training, Olanzapine
- Where
- 2 sites in United States
- Volunteers
- 107 people
- Sponsor
- University of California, Los Angeles
Schizophrenia
Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119
This study will consist of 2 parts: Part Ⅰ-in healthy adult subjects, Part Ⅱ-in adult patients with schizophrenia
- Trial name
- NCT06504290
- Testing
- VV119 （in healthy adult subjects）, VV119(in adult patients with schizophrenia)
- Where
- 4 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Schizophrenia
The Safety and Efficacy of Lurasidone With Different Initiation Dose in Chinese Acute Phase Patients With Schizophrenia
To evaluate the safety and efficacy of Lurasidone initiated with 40mg and 80mg in treatment with acute phase patients with schizophrenia
- Trial name
- NCT05011669
- Testing
- Lurasidone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Diabetes, Schizophrenia
Pioglitazone as a Treatment for Lipid and Glucose Abnormalities In Patients With Schizophrenia
This is a study with an approved drug for treating type 2 diabetes, for its effects on treating glucose and lipid abnormalities in patients being treated with first or second-generation antipsychotics, and comparison of effects…
- Conditions
- Diabetes, Schizophrenia, Insulin Resistance, Cognitive Impairment
- Trial name
- NCT00231894
- Testing
- Pioglitazone, Life style diet group
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Bipolar Disorder, Schizophrenia
Post-Authorization Safety Surveillance Study of Asenapine in Participants With Bipolar Disorder (P08307)
This study will assess asenapine (Sycrest®) use in participants with bipolar disorder; comparison will be made to the use of risperidone (RISPERDAL®CONSTA®) and olanzapine (Zyprexa®).
- Trial name
- NCT01495741
- Volunteers
- 42 people
- Sponsor
- Organon and Co
Schizophrenia
A Study for Participants With Schizophrenia
The purpose of this study is to test the hypothesis that 1 or more dose levels of LY2140023 given orally to participants with schizophrenia twice daily for 4 weeks will have significantly greater effect than placebo.
- Trial name
- NCT00520923
- Testing
- LY2140023, Olanzapine
- Where
- 35 sites in Argentina, Austria and 7 more
- Volunteers
- 669 people
- Sponsor
- Denovo Biopharma LLC
Medication Adherence
A Smartphone App on Medication Adherence
This is an experimental study which aims to explore the effectiveness of a smartphone app for medication adherence (MedAdhere app) among schizophrenic patients for eight weeks.
- Trial name
- App (NCT05892120)
- Testing
- the MedAdhere app
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Schizophrenia
Aripiprazole Augmentation for Clozapine-Treated Patients With Refractory Schizophrenia
The purpose of this study is to determine whether aripiprazole augmentation is safe and effective in the treatment of clozapine-treated patients with refractory schizophrenia.
- Trial name
- NCT00328367
- Testing
- aripiprazole
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Seoul National University Hospital
Schizophrenia
A Pharmacokinetic Study of MP-214 in Patients With Schizophrenia
The objective of this study is to evaluate the pharmacokinetics, safety and efficacy of MP-214 in patients with schizophrenia.
- Trial name
- NCT01626859
- Testing
- MP-214 3mg, MP-214 6mg, MP-214 9mg
- Where
- Japan
- Volunteers
- 38 people
- Sponsor
- Tanabe Pharma Corporation
Psychotic Disorders, Schizophrenia
Pentosan Polysulfate Sodium and Meclofenamic Acid as Treatments in Patients With Psychotic Disorders
This study evaluates the feasibility of administering meclofenamic acid or pentosan polysulfate sodium as an adjunctive treatment to patients diagnosed with a psychotic disorder.
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02930005
- Testing
- Meclofenamic acid, Pentosan polysulfate sodium
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- The University of Texas Health Science Center, Houston
Schizophrenia, Caregiver Burden
Psychological Resilience and Quality of Life Among Caregivers of Patients With Schizophrenia
Schizophrenia is a severe and chronic psychiatric disorder that requires long-term care management, placing family members who serve as informal caregivers under substantial psychological, physical, and financial strain.
- Conditions
- Schizophrenia, Caregiver Burden, Quality of Life
- Trial name
- NCT07837479
- Volunteers
- 130 people
- Sponsor
- Assiut University
Schizophrenia, Schizoaffective Disorder
Equivalence of Generic Clozapine to Orally Dissolving Clozapine in Schizophrenia or Schizoaffective Disorder
The purpose of this study is to obtain data on equivalence of generic clozapine to Fazaclo (orally disintegrating tablet). Generic clozapine is the most frequently used clozapine and such data is important for clinicians to have.
- Trial name
- NCT00501618
- Testing
- Fazaclo
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Manhattan Psychiatric Center
Healthy, Schizophrenia
Neuroimaging of Dopamine Metabolism in Normal and Psychiatric Patients
Brain cells communicate with each other by releasing chemicals called neurotransmitters. In order for brain cells to transfer information, one cell will release a neurotransmitter that will be recognized by a receptor located on…
- Trial name
- NCT00001320
- Where
- United States
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Schizophrenia and Disorders With Psychotic Features
Social Skills Training in Refractory Schizophrenia
Objective Primary: To evaluate the efficacy of social skills training in reducing negative symptoms in patients with refractory schizophrenia, in comparison with control (befriending group).
- Trial name
- SST (NCT00791882)
- Testing
- Social Skills Training
- Where
- Brazil
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo
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