Clinical trials: Patients Undergoing Cardiac Surgery
Diastolic Dysfunction
Perioperative Measurements of Diastolic Function in Cardiac Surgery
This observational clinical trial will investigate the following perioperative indices relating to cardiac surgery: 1. The significance of measurements involving left heart relaxation (LV diastolic function) and its relation to…
- Trial name
- NCT02285309
- Testing
- Cardiac Surgery and enoximone
- Volunteers
- 100 people
- Sponsor
- University College, London
Cognitive Impairment (CI)
Post-operative Functional Disability in Unrecognized Cognitive Impairment (POF) Study
This is a prospective multicenter cohort study, which will determine the prevalence of preoperative cognitive impairment (CI) using the Modified Telephone Interview for Cognitive Status (TICS-M), Eight-items interview to…
- Trial name
- NCT04850833
- Where
- 2 sites in Canada
- Volunteers
- 390 people
- Sponsor
- University Health Network, Toronto
Pain, Pain Management Following Cardiopulmonary Bypass Surgery
Addition of Dexmedetomidine to Ropivacaine in Bilateral Erector Spinae Plane Block in Patients Undergoing Coronary Artery Bypass Surgery
Coronary artery bypass surgery (CABG), typically performed through a median sternotomy, causes significant postoperative pain. Managing this pain effectively while reducing reliance on opioids is essential, as opioids can lead to…
- Conditions
- Pain, Pain Management Following Cardiopulmonary Bypass Surgery, Erector Spinae Plane Block
- Trial name
- NCT06981949
- Testing
- Dexmedetomidine, Ropivacaine
- Volunteers
- 110 people
- Sponsor
- Lebanese American University
Pain, Postoperative
Analgesic Efficacy of Bilateral US Guided TTPB vs ESPB in Pediatric Patients Undergoing Corrective Cardiac Surgeries
Corrective cardiac surgeries include a bundle of major surgeries that take place in pediatric patients and require imperative perioperative pain control; hence, the art of healing starts from trying to diminish or abolish pain.
- Trial name
- NCT05559684
- Testing
- Erector spinae plane block, Transversus thoracis plane block
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Patients Undergoing Cardiothoracic Surgery
Limiting IV Chloride to Reduce AKI After Cardiac Surgery
This primary aim of this study is to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery.
- Trial name
- LICRA (NCT02020538)
- Testing
- Low-chloride perioperative intravenous fluid strategy, High-chloride perioperative intravenous fluid strategy
- Where
- Australia
- Volunteers
- 1,298 people
- Sponsor
- Bayside Health
Erector Spinae Plane Block
Continuous ESP Block in Patients Undergoing CABG Surgery.
This study addresses articles and studies related to the erector spinae plane (ESP) block and its technique, advantages and disadvantages, applicability, among others.
- Trial name
- NCT07666178
- Testing
- Ropivacaine, Standard Postoperative Analgesics
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Instituto do Coracao
Surgery, Cardiac, Atrial Fibrillation
Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation is quite common after cardiac surgery with up to 1 in 3 patients experiencing this abnormal heart rhythm.
- Trial name
- PATRONUS (NCT05543278)
- Testing
- Amiodarone
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital
Postoperative Delirium, Elderly Patients
The Effects of Subanesthetic S-ketamine on Postoperative Delirium and Cognitive Function in the Elderly Undergoing Non-cardiac Thoracic Surgery
Postoperative delirium (POD) is a common and distressing complication after thoracic surgery. S-ketamine has neuroprotective properties as a dissociative anesthetic.
- Trial name
- SKED (NCT05242692)
- Testing
- S-ketamine, Dexmedetomidine
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Perioperative Hemodynamic Optimization, Cardiac Surgery
Goal-directed Resuscitation in High-risk Patients Undergoing Cardiac Surgery
The primary aim of the study is to investigate whether a goal-directed resuscitation therapy in high-risk patients through cardiac index optimization using the LiDCO Rapid device reduces complications after cardiac surgery.
- Trial name
- GRICS (NCT01470976)
- Testing
- Goal-directed Resuscitation Therapy (GDT), Standard protocol
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo
Cardiac Valve Replacement Complication
Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery
This study evaluates the effect of Vitamin D supplementation on ICU and hospital LOS in patients undergoing valve replacement surgery.
- Trial name
- NCT04085770
- Testing
- Alfacalcidol 1 MCG Oral Capsule
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Cairo University
Postoperative Pain, Sternotomy Pain
Comparison of Erector Spinae Plane Block (ESPB) With the Combination of Superficial Parasternal Intercostal Plane Block (SPIPB) and Serratus Anterior Plane Block (SAPB) in the Management of Postoperative Sternotomy Pain in Patients Undergoing Cardiac Surgery Via Sternotomy
This study aims to compare the effectiveness of two regional anesthesia techniques in managing pain for participants undergoing cardiac surgery via sternotomy.
- Conditions
- Postoperative Pain, Sternotomy Pain, Acute Pain, Cardiac Surgery
- Trial name
- NCT07472296
- Testing
- Erector spinae plane block (ESPB), Superficial Parasternal Intercostal Plane Block (SPIPB), Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uludag University
Coronary Artery Disease
Association Between Intraoperative Pulse Pressure Variation and Postoperative Lactate Clearance in Cardiac Surgery
This study aims to evaluate the relationship between intraoperative pulse pressure variation (PPV) and postoperative lactate clearance in adult patients undergoing elective cardiac surgery.
- Trial name
- NCT07871188
- Testing
- No Study-Specific Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Elzem SEN
Valvular Heart Disease
Comparing Measurements of the Aortic Valve Taken During Surgery With Those Obtained Before Surgery Using Computed Tomography Scans, in Patients Undergoing Surgical Aortic Valve Replacement
This study aims to understand why there may be differences between the measurements of the aortic valve taken before and during surgery.
- Trial name
- SAVR-CT-AVA (NCT07125469)
- Testing
- The measurements taken from the CT scan will be used to determine the appropriate size for two types of theoretical Transcatheter Aortic Valve Replacement (TAVR) prostheses
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Maria Cecilia Hospital
Intra-Abdominal Hypertension, Postoperative Complications
The Impact of Intra-Abdominal Pressure on Mortality and Morbidity in Patients Undergoing Open-Heart Surgery
This prospective observational study evaluated whether increased intra-abdominal pressure, meaning increased pressure inside the abdomen, is associated with postoperative complications and mortality in adults undergoing elective…
- Trial name
- NCT07752082
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Pulmonary Atelectasis, Morbid Obesity
Use of Airway Pressure Release Ventilation in Morbidly Obese Patients Undergoing Open Heart Surgery
The goal of this Randomized Clinical trial is to to investigate if the use of Air Pressure Release Ventilation in morbidly obese patients undergoing open heart surgery will improve post operative pulmonary outcomes 60 Patients…
- Conditions
- Pulmonary Atelectasis, Morbid Obesity, Pulmonary Complication
- Trial name
- NCT05670483
- Testing
- Use Of APRV mode of Ventilation, Use of conventional Synchronized Intermittent Mandatory Ventilation (SIMV) volume control mode
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Coronary Artery Bypass Grafting, Mitral Valve Surgery
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass
A study to evaluate levosimendan compared with placebo in reducing the composite event rate of all-cause death, perioperative MI, need for new dialysis, or use of mechanical assist (IABP, LVAD or ECMO) in subjects with reduced…
- Conditions
- Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
- Trial name
- LEVO-CTS (NCT02025621)
- Testing
- Levosimendan
- Where
- 60 sites in United States, Canada
- Volunteers
- 882 people
- Sponsor
- Tenax Therapeutics, Inc.
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Valvular Heart Disease Patients
The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery
Ischemic reperfusion injury of cardiopulmonary bypass and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing valvular heart surgery.
- Trial name
- NCT02720549
- Testing
- remote ischemic postconditioning, valvular surgery with bypass
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Yonsei University
Fluid Responsiveness
Peripheral Venous Pressure Variation and Fluid Responsiveness
The decision to give fluids or not should not be taken lightly. Indeed, excessive or insufficient fluid administration is associated with increased morbidity and mortality.
- Trial name
- NCT05131516
- Testing
- Alveolar recrutment maneuver
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Erasme University Hospital
Myocardial Injury
Effects of Remimazolam on Postoperative Myocardial Injury
This study is designed as a prospective, double-blind, randomized controlled trial to investigate the effect of remimazolam on intraoperative cardiac output (CO) in elderly patients undergoing general anesthesia, and to evaluate…
- Trial name
- NCT07725185
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Affiliated Hospital of Jiaxing University