Clinical trials: Patients Undergoing Cardiac Surgery
Left Atrial Appendage Exclusion
AtriCure Exclusion of the LAA in Patients Undergoing Concomitant Cardiac Surgery
Prospective, non-randomized trial to evaluate the safety and efficacy of the LAA Exclusion Device (Clip) for the exclusion of the LAA via epicardial tissue approximation.
- Trial name
- EXCLUDE (NCT00779857)
- Testing
- AtriCure LAA Exclusion System
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- AtriCure, Inc.
Acute Normovolemic Hemodilution, Off-Pump Coronary Artery Bypass Surgery
Acute Normovolemic Hemodilution in Off-pump CABG
To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery
- Trial name
- NCT04042883
- Testing
- Acute normovolemic hemodilution
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cardiac Complication, Perioperative Complication
Trimodal Prehabilitation in Patients Undergoing Elective Surgery
Patients scheduled for elective surgery will undergo 4 week course of trimodal prehabilitation
- Trial name
- NCT05114408
- Testing
- 4 week trimodal prehabilitation course
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Cardiovascular Diseases, Coronary Artery Disease
The Effect of Continued Mechanical Ventilation on the Occurrence of Myocardial Ischemia
The goal of this study is to examine the influence of mechanical ventilation on the occurrence of myocardial ischemia in patients undergoing endo-CABG.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia, Hypoxia
- Trial name
- VENTMICS-II (NCT05417217)
- Testing
- Discontinued ventilation, Continued ventilation
- Where
- Belgium
- Volunteers
- 165 people
- Sponsor
- Jessa Hospital
Atrial Fibrillation
Atrial Tissue Banking: Atrial Tissue Obtained From Patients Undergoing Heart Surgery
Over the past decade, techniques have been refined which permit an enormous amount of information relevant to disease mechanisms to be gained from the examination of heart tissue.
- Trial name
- NCT00248274
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
Heart Rate Variability
Does Heart Rate Variablity (HRV) Predict Hypotension in Patients Undergoing Cervical Myelopathy Surgery ?
Cervical myelopathy is commonly associated with degenerative spinal disease. Dysfunction of the autonomic nervous system is also evident in many cases of cervical myelopathy.
- Trial name
- NCT02360085
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Lashmi Venkatraghavan
Children With Heart Defects
Heparin Responses in Pediatric Patients Undergoing Cardiopulmonary Bypass.
Heparin is an anticoagulant or "blood thinner". Heparin is always given to patients undergoing open-heart surgery to prevent blood from clotting when a patient is placed on the heart-lung machine.
- Trial name
- NCT00166140
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Emory University
Coronary Artery Disease, Stable Angina
Study Comparing Ticagrelor With Aspirin for Prevention of Vascular Events in Patients Undergoing CABG
The primary objective of this study ist to test the hypothesis that ticagrelor is superior to Aspirin (ASA) fort he prevention of major cardio- and cerebrovascular events (MACCE) in patients undergoing artery bypass operation.
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- TiCAB (NCT01755520)
- Testing
- Ticagrelor, Aspirin
- Where
- 29 sites in Austria, Germany and 1 more
- Volunteers
- 1,893 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Left Atrial Appendage Thrombosis
The Left Atrial Appendage Closure by Surgery and the Incidence of Stroke in Patients Undergoing Open-heart Surgery.
This study aims to assess the efficacy and safety of prophylactic surgical closure of the left atrial appendage for stroke and cardiovascular death prevention in patients undergoing open heart surgery, regardless of their…
- Trial name
- NCT06172738
- Testing
- the left atrial appendage closure through surgery.
- Volunteers
- 100 people
- Sponsor
- Assiut University
Nursing Care, Quality of Life
Nurse Led Transitional Care Model in Cardiac Surgery
To evaluate the effectiveness of Nurse Led Transitional Care Model (TCM) on the functional autonomy, quality of life and rehospitalization rates of elderly patients undergoing open heart surgery.
- Conditions
- Nursing Care, Quality of Life, Transitional Care
- Trial name
- NCT04384289
- Testing
- Nursing care based on the Transitonal Care Model
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Delirium - Postoperative, Sleep Problems
Effect of Preoperative Sleep Intervention on Postoperative Delirium in Adult Patients Undergoing Cardiac Surgery
This is a multicenter, randomized, controlled clinical trial aimed to determine whether preoperative sleep interventions could reduce the incidence of adverse outcomes, such as postoperative delirium, in adult patients undergoing…
- Conditions
- Delirium - Postoperative, Sleep Problems, CABG, Valve Surgery
- Trial name
- NCT06777342
- Testing
- Cognitive behavioral therapy intervention, Melatonin intervention
- Volunteers
- 1,281 people
- Sponsor
- Yan Fuxia
Myocardial Injury
Effect of Delayed Remote Ischemic Preconditioning on Myocardial Injury
The purpose of this study is to evaluate delayed myocardial protective effect of RIPC in patients undergoing cardiac valve replacement surgery.
- Trial name
- RIPC (NCT01903161)
- Testing
- delayed remote ischemic preconditioning, control
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Pain, Blood Pressure
Effects of Music on Procedural Pain in Distal Radius Fracture Reduction
This randomized controlled trial (RCT) evaluates the effectiveness of music as a complementary intervention for pain control during non-surgical reduction of distal radius fractures in orthopedic patients.
- Conditions
- Pain, Blood Pressure, Heart Rate, Music Therapy
- Trial name
- NCT07344883
- Testing
- Music intervention Group 1, Music intervention Group 2
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Heart Disease, Atrial Fibrillation
Diastolic Dysfunction and Atrial Fibrillation in CABG Surgery
Left ventricular (LV) diastolic dysfunction is a common manifestation of heart disease that is responsible for significant morbidity and mortality.It is present when the ventricular filling is impaired as a result of delayed…
- Trial name
- NCT00188903
- Testing
- Diastolic measurements during TEE
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University Health Network, Toronto
Vasoplegia, Vasoplegic Shock
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
- Trial name
- RAAS-HLM (NCT05833828)
- Testing
- on-pump surgery, off-pump surgery
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Universität Münster
Kidney Failure, Acute
Effect of Erythropoietin (EPO) in Kidney After Cardiac Surgery
The purpose of this study is to determine whether erythropoietin is effective in preventing acute kidney dysfunction after coronary artery bypass grafting surgery.
- Trial name
- EPO-CABG (NCT00654992)
- Testing
- Erythropoietin-Beta, Normal Saline
- Where
- South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Pancreas Disease, Troponin T
Cardiac Cycle Efficiency and Postoperative Troponin
Knowing how intraoperative anesthesia management and cardiac cycle monitoring affect postoperative cardiac outcomes in patients undergoing pancreatic surgery can help develop a protocol for future cases.
- Conditions
- Pancreas Disease, Troponin T, Hemodynamic Monitoring, MINS
- Trial name
- NCT07778914
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul Saglik Bilimleri University
Bypass Complication, Respiratory Complication
Aortic Cross Clamping Time, and Postoperative Respiratory Function
Does the duration of cardiopulmonary bypass, and aortic cross clamping affects the post operative pulmonary function.
- Trial name
- NCT03072784
- Testing
- aortic cross clamping
- Where
- Egypt
- Volunteers
- 53 people
- Sponsor
- Assiut University
Coronary Artery Disease
TEAM-Project: Trial on the Effect of Anesthetics on Morbidity and Mortality
Volatile anesthetics may provide some protection from myocardial ischemia, an effect called anesthetic preconditioning. In patients undergoing coronary artery bypass surgery, this preconditioning effect resulted in better cardiac…
- Trial name
- NCT00286585
- Testing
- Inhalational anesthetic, Intravenous anesthetic, propofol
- Where
- 3 sites in Switzerland
- Volunteers
- 385 people
- Sponsor
- University Hospital, Basel, Switzerland
Laryngoscopic Stress Response, Dexmedetomidine
Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication.
- Conditions
- Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine
- Trial name
- NCT07611890
- Testing
- IV dexmedetomidine, IV Lignocaine
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Rawalpindi Institute of Cardiology