Clinical trials: Patients Undergoing General Anesthesia
Intubation, Endotracheal
Ambu® Laryngeal Mask as an Intubation Conduit
The purpose of this study is to determine if the Ambu Laryngeal Mask can be used as an intubation conduit for endotracheal intubation.
- Trial name
- NCT00272194
- Testing
- Ambu Laryngeal Mask, Aintree Exchange Catheter, Laryngeal Mask Airway
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Nausea and Vomiting
Caffeine in the Prevention of Post-operative Nausea and Vomiting
The objective of this study is to determine if caffeine 500 mg intravenously is efficacious when added to standard anti-emetic prophylaxis in the prevention of post-operative nausea and vomiting (PONV) in patients undergoing…
- Trial name
- NCT00130026
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Beth Israel Deaconess Medical Center
Surgeries Undergoing General Anesthesia
Impact of Intraoperative Oxygenation Practices on Patient Outcomes
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80)…
- Trial name
- IntraOp Ox (NCT07224243)
- Testing
- Lower FiO2, Intermediate FiO2, Higher FiO2
- Where
- 4 sites in United States
- Volunteers
- 54,000 people
- Sponsor
- Frederic T Billings IV
Etomidate is Mixed With Propofol
Etomidate/Propofol Mixture or Propofol Monotherapy Use in Patients Undergoing General Anesthesia
The purpose of this study was to investigate the effects of different proportions of etomidate/propofol mixture and propofol alone intravenous anesthesia on intraoperative and postoperative physiological indicators and…
- Trial name
- NCT03855267
- Testing
- Propofol 20 MG/ML, Propofol 20 mg/ml , etomidate 2 mg/ml
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Guolin Wang
Inflammation, Anesthesia
Effect of Anesthesia Method on Neutrophil-Lymphocyte Ratio
The neutrophil/lymphocyte ratio (NLR) is a simple and inexpensive marker of the inflammatory response. NLR is affected not only by surgical trauma but also by the anesthetic method.
- Trial name
- NCT05628935
- Testing
- peripheral nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Zonguldak Bulent Ecevit University
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Adult Patients Undergoing Elective Surgery With General Anesthesia and LMA Insertion
Comparison Between Lidocaine Inhalation and Intravenous Dexamethasone in Reducing Pain After Laryngeal Mask Insertion
This study aimed to compare the efficacy between lidocaine inhalation vs intravenous dexamethasone to reduce pain after laryngeal mask insertion
- Trial name
- NCT03139591
- Testing
- lidocaine inhalation; intravenous dexamethasone
- Where
- Indonesia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Adult Brain Tumor
Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy
This randomized clinical trial studies light sedation compared with intubated general anesthesia (a loss of feeling and a complete loss of awareness that feels like a very deep sleep) in reducing complications and length of…
- Trial name
- NCT02193568
- Testing
- Arm I (light sedation), Arm II (intubated general anesthesia)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Osteoarthritis
Early Mobilization After Total Knee Arthroplasty
Patients undergoing elective total knee arthroplasty are randomized to either intrathecal anesthesia, wound infiltration with local anesthetics and standardized postoperative care (NA = neuraxial anesthesia) or general…
- Trial name
- NCT01604382
- Testing
- General Anesthesia, Neuraxial anesthesia
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Delirium, Postoperative
Perioperative Risk Factors for Postoperative Delirium in Children
Despite recent advances in postoperative delirium research, the proportion of children with postoperative delirium is still high.
- Trial name
- NCT01032161
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huazhong University of Science and Technology
Post Operative Pain
Postoperative Analgesia in Patients Undergoing Elective Lumbar Fusion Operations Under General Anesthesia
It was proven that intrathecal opioids are considered as an effective means of pain control in several major surgical interventions including spine surgeries.
- Trial name
- NCT05338320
- Testing
- Ultrasound Guided Erector Spinae Plane Block, Intrathecal morphine, General anesthesia using intravenous fentanyl (1µg/kg)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Combination of General Anesthesia to Spinal and Epidural Techniques
Combination of Spinal-Epidural With General Anesthesia in Patients Undergoing Mega-Liposuction Surgery
The combination of general anesthesia to spinal and epidural techniques (CSEGA) proved to have a synergistic effect, thus, the use of sub-anesthetic doses can provide satisfactory anesthetic and analgesic results.
- Trial name
- NCT05301127
- Testing
- spinal-epidural device
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Organ Protection
Effect of Intravenous Lidocaine on Serum miRNA-135a in Patients Undergoing Non-cardiac Surgery
The purpose of this study is to investigate the effects of intravenous lidocaine on serum miRNA-135a and its downstream proteins Rock2 and Add1 in elderly patients undergoing non-cardiac under general anesthesia.
- Trial name
- NCT05503043
- Testing
- Lidocaine, Normal saline
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Anesthesia
Study of the Efficacy and Safety of Remimazolam in General Anesthesia in Adults Undergoing Cardiac Surgery
This study investigates the use of remimazolam as a sedative/hypnotic in general anesthesia. Remimazolam or propofol will be administered together with fentanyl/sufentanil/remifentanil as opioid analgesics and a neuromuscular…
- Trial name
- NCT02523859
- Testing
- Propofol, Remimazolam
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Paion UK Ltd.
Postoperative Pain
EXORA vs ESP Blocks in Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is still considered the gold standard for the surgical management of gallbladder disease due to its minimally invasive nature, shorter recovery time, and reduced postoperative complications.
- Trial name
- NCT07187310
- Testing
- EXORA block, Erector Spinae Plane block
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Fayoum University Hospital
Laparoscopic Surgery
Effects of Continuous Dexmedetomidine Infusion on Systemic Microvascular Function in Laparoscopic Cholecystecthomy
The microcirculation represents the primary site of exchange of oxygen and nutrients for tissues, and the preservation of microcirculatory perfusion is essential for the maintenance of organ function.
- Trial name
- NCT04946396
- Testing
- dexmedetomidine intravenous infusion, 0.9%sodium chloride
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Pain, Postoperative
Usefulness of Lidocaine in Oral and Maxillofacial Surgeries Under General Anesthesia for Pain Control After Operation
This will be a randomized double blinded clinical study conducted in patients undergoing oral and maxillofacial surgery under general anesthesia.
- Trial name
- NCT03479320
- Testing
- Lidocaine
- Where
- Nepal
- Volunteers
- 40 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Surgical Complications From General Anesthesia, Hypertension
Monitoring Hypertensive Patients's Cerebral Oxygen Saturation
The purpose of this study is to determine whether there is a significant decrease in cerebral oxygen saturation in hypertensive patients undergoing major abdominal surgery and their correlation with standard monitoring parameters.
- Conditions
- Surgical Complications From General Anesthesia, Hypertension, Cerebral Ischemia, Cerebral Anoxia
- Trial name
- MHPCOS (NCT02147275)
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Huazhong University of Science and Technology
Opioid Free Anesthesia
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Patients undergoing nephrectomy have a high incidence of postoperative pain. In the perioperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.
- Trial name
- NCT05312541
- Testing
- pre emptive local anaesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Anesthesia, General
Efficacy and Safety of Ciprofol Compared to Propofol for Nonintubated General Anesthesia in Patients Undergoing TAVR
The purpose of this study is to explore the efficacy and safety of ciprofol compared to propofol for non-intubated general anesthesia in patients undergoing transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT05035069
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.