Clinical trials: Patients Undergoing Laparoscopic Surgery
Postoperative Pain, Cholelithiasis
Comparative Efficacy of ESPB and EOPB for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Randomized Controlled Trial (External Oblique Intercostal Plan Block (EOPB) and Erector Spina Plan Block (ESPB) )
This randomized controlled clinical trial investigates the comparative efficacy of two novel regional anesthesia techniques - the Erector Spinae Plane Block (ESPB) and the External Oblique Intercostal Plane Block (EOPB) - for…
- Conditions
- Postoperative Pain, Cholelithiasis, Acute Pain
- Trial name
- NCT07057934
- Testing
- ESPB Block, EOPB Block, Standard Systemic Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Oxytocin, Hemodynamic Monitoring
Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy
This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of…
- Conditions
- Oxytocin, Hemodynamic Monitoring, Laparoscopic Surgery
- Trial name
- NCT04109339
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yangzhou University
Prostate Cancer (Adenocarcinoma), Prostate Cancer (Post Prostatectomy)
Robotic Prostatectomy Artificial Intelligence Low Pressure Pain (RALP) Trial
The 'Robotic Prostatectomy Artificial Intelligence Low Pressure Pain Study Trial' aims to assess the feasibility of being able to review operative outcomes such as pain when comparing two commonly used surgical devices for the…
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate Cancer (Post Prostatectomy), Prostate Cancer Surgery, Prostate Cancers
- Trial name
- NCT06915909
- Testing
- surgery
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- East and North Hertfordshire NHS Trust
Pain
A Study of the Recovery Benefits After Treatment With Parecoxib/Valdecoxib in Patients Undergoing Abdominal Surgery
The purpose of this study is to evaluate morphine intake in the first 4 hours after abdominal surgery. Morphine intake is compared between patients on placebo and patients on parecoxib/valdecoxib.
- Trial name
- NCT00651300
- Testing
- Parecoxib/Valdecoxib
- Where
- 8 sites in Australia
- Volunteers
- 91 people
- Sponsor
- Pfizer
Pulmonary Complication
Effect of Prone Position Training on Pulmonary Complications in Patients Undergoing Laparoscopic Colorectal Surgery
Colorectal cancer is a common digestive tract tumor in China. At present, laparoscopic surgery has become the classic operation of colorectal cancer surgery compared with the traditional open abdominal surgery.
- Trial name
- NCT06001411
- Testing
- Prone Position Training, control group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Min Su
PONV
Amisulpride for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study aims to focus on patients undergoing gynecological laparoscopic surgery and further evaluate the role of amisulpride in preventing postoperative nausea and vomiting in these patients.
- Trial name
- Amisulpride (NCT07554040)
- Testing
- Tropisetron
- Volunteers
- 526 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bariatric Surgery (Sleeve Gastrectomy ), Hemodynamics
Effect of Intraoperative Position Change on Hemodynamics and Electrocardiography
The combined effects of obesity-related cardiac structure and function changes, comorbidities, pneumoperitoneum technique, and reverse Trendelenburg position may complicate anesthesia management by affecting intraoperative…
- Conditions
- Bariatric Surgery (Sleeve Gastrectomy ), Hemodynamics, Electrocardiography
- Trial name
- NCT06835166
- Testing
- 12-lead electrocardiography measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Firat University
Patients Undergoing Laparoscopic Surgery
Looking at Safety and Feasibility of Novel Laparoscopic Device (LapSpace)
In order to help the surgeons to clearly visualize their target operating area and create an optimal operative field throughout the procedure, the device owners have developed a new class of inflatable laparoscopic retractors for…
- Trial name
- NCT03210636
- Testing
- LapSpace
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Laparoscopic Nephrectomy, Cerebral Oxygen Saturation
Pneumoperitoneum and Cerebral Oxygenation
In this study, the changes in cerebral oxygen saturation due to low and high pressure pneumoperitoneum implementation were measured in patients who underwent laparoscopic nephrectomy.
- Trial name
- NCT04671121
- Testing
- Standart pressure pneumoperitoneum, Low pressure pneumoperitoneum
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Ondokuz Mayıs University
Acute Appendicitis, Abdominal Pain (AP)
Preserving or Resecting the Normal Appendix in Patients Undergoing Laparoscopy Surgery for Suspected Appendicitis
When appendicitis is suspected, patients are typically planned for emergency surgery preferably using a laparoscopic approach. Up to 20% of these patients will have a normal appendix, thus not suffering from appendicitis.
- Conditions
- Acute Appendicitis, Abdominal Pain (AP), Diagnostic Laparoscopy, Laparoscopic Appendectomy
- Trial name
- NCT06917612
- Testing
- Normal diagnostic laparoscopy, Negative appendectomy
- Volunteers
- 20,000 people
- Sponsor
- Herlev Hospital
Obesity, Mechanical Ventilation Pressure High
Evaluation of Regional Lung Mechanics in Obese Patients Undergoing Laparoscopic Surgery
This study will evaluate what is the impact of laparoscopy and Trendelenburg position on lung regional ventilation distribution in obese patients, focusing on the differences between the different phases of surgery.
- Conditions
- Obesity, Mechanical Ventilation Pressure High, Intraoperative Respiratory Injury
- Trial name
- OBESE-EIT (NCT05554536)
- Testing
- PEEP titration trial
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Obesity; Drug
Evaluation of the Effect of Different Doses Dexmedetomidine Infusion on Lung Mechanics and Oxygenation in Obese Patients
The objective of this study is to evaluate the effect of different doses of dexmedetomidine infusion intraoperative on lung mechanics and oxygenation regarding PaO2/Fraction of inspired oxygen), Intraoperative oxygenation, lung…
- Trial name
- NCT04730375
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Egypt
Gynecologic Disease
Comparison of Two Ventilation Modes With Laryngeal Mask Airway Guardian
The purpose of this study is to compare volume- and pressure- controlled ventilation with laryngeal mask airway Guardian in obese patients undergoing laparoscopic gynecologic surgery in terms of ventilatory efficacy, airway leak…
- Trial name
- wang002 (NCT02097628)
- Testing
- tidal volume, peak airway pressure
- Volunteers
- 40 people
- Sponsor
- Haiyun Wang
Analgesia, Caffeine
Caffeine Intake Inrelation to Perioperative Analgesic Consumption
Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate.
- Trial name
- NCT05330754
- Testing
- Caffeine intake in mg
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Postoperative Cognitive Dysfunction
Optic Nerve Sheath Diameter and Postoperative Cognitive Disfunction at Laparoscopic Surgery
Purpose: Pneumoperitoneum during laparoscopic abdominal surgery increases intra-abdominal pressure (IAP), potentially altering intracranial pressure (ICP) and cerebral oxygenation, with unclear implications for early…
- Trial name
- NCT07264764
- Testing
- Optic nerve sheath diameter (ONSD)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Duzce University
Neuromuscular Blockade
Comparison of Two Quantitative EMG Monitors for Deep Neuromuscular Block in Laparoscopic/Robotic and VATS Surgery
The main objective of the study is to compare the frequency of intraoperative spontaneous diaphragmatic movements and breath-initiation efforts in participants undergoing robotic and/or thoracic surgery under deep neuromuscular…
- Trial name
- NCT07706504
- Testing
- TetraGraph (Senzime)-Guided Neuromuscular Monitoring (Dominant Hand), TwitchView (Blink)-Guided Neuromuscular Monitoring (Dominant Hand)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Rectal Tumors, Tumor of Sigmoid Colon
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
The primary change in aging lung tissue among older people is atrophy, leading to a significant decline in ventilatory function.
- Conditions
- Rectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, Laparoscopic
- Trial name
- Dex (NCT07385898)
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Prostate Cancer
The Effects of Epidural Anesthesia on the Bioavailability of Nitric Oxide and Renal Function in Patients Undergoing Laparoscopic Surgery
This study was designed to investigate the effects of epidural anesthesia combined with general anesthesia during laparoscopic surgery.
- Trial name
- NCT01325844
- Testing
- Epidural anesthesia
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Yonsei University
Postoperative Pain
Comparison of Postoperative Pain Management in Patients Undergoing Laparoscopic Colorectal Surgery Under Enhanced Recovery After Surgery (ERAS) Program, Laparoscopic Colorectal Surgery Without ERAS and Open Colorectal Surgery
This is a retrospective study to compare postoperative pain intensity in patients going laparoscopic colorectal surgery with Enhanced Recovery after Surgery (ERAS), without ERAS and open colorectal surgery.
- Trial name
- NCT04997174
- Testing
- Celecoxib
- Where
- Thailand
- Volunteers
- 162 people
- Sponsor
- Prince of Songkla University
Electrical Impedance Tomography
PEEP Titration Guided by Electrical Impedance Tomography in Laparoscopic Surgery The PEaRL Study
Background: Laparoscopic surgery has gained widespread adoption due to its minimally invasive nature, offering advantages such as reduced postoperative pain, shorter hospitalization, and faster functional recovery compared with…
- Trial name
- PEaRL (NCT07289113)
- Testing
- A PEEP trial performed with the PulmoVista® 500 (Dräger, Lübeck, Germany) is a procedure designed to identify the optimal level of positive end-expiratory pressure
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- ASST Fatebenefratelli Sacco