Clinical trials: Patients Undergoing Spine Surgery
S-ketamine, Postoperative Analgesia
Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Despite opioid-based multimodal analgesia, moderate-to-severe pain remains a big problem in patients following multi-segment spinal fusion.
- Conditions
- S-ketamine, Postoperative Analgesia, Spine Fusion
- Trial name
- NCT04964219
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
Collapse of Thoracic Vertebra, Collapse of Lumbar Vertebrae
Study of Dexmedetomidine in Spine Surgery
The investigators will conduct a prospective randomized double blind study comparing methadone plus methadone and intraoperative dexmedetomidine in multi-level spine surgery in two randomized groups.
- Trial name
- NCT01850017
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Blood Loss
Comparison of Three Methods of Hemoglobin Monitoring
The purpose of this study is to compare the hemoglobin results obtained with 1) the HemoCue™, 2) the Masimo SpHb™, and 3) the UCSF Clinical Laboratory.
- Trial name
- NCT00792597
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Spinal Disease, Anesthesia
Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds
The purpose of this study is to determine the effect of lidocaine infusion on intraoperative neuromonitoring in patients undergoing spine surgery.
- Conditions
- Spinal Disease, Anesthesia, Post Operative Pain
- Trial name
- NCT06792474
- Testing
- Lidocaine in Saline, Normal saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cervical Spine Degeneration
Analgesic Effectiveness of Nefopam in Patients Undergoing Anterior Cervical Spine Surgery
Nefopam is a benzoxazocine derivative which is non-opioid and non NSAIDs. The previous studies showed that nefopam can inhibit reuptake of serotonin, norepinephrine and dopamine.
- Trial name
- NCT03955705
- Testing
- Nefopam 20 mg/ml, Normal saline
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mahidol University
for Post-operative Pain Relief in Spine Surgeries
Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial.
Low dose perioperative ketamine infusion and it's effect on postoperative pain score, sedation score and narcotic consumption in patients undergoing spine surgery: A prospective randomized double blind control trial.
- Trial name
- NCT04259476
- Testing
- Ketamine Hydrochloride
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Postoperative Delirium
Efficacy of Erector Spinae Plane Block on Postoperative Delirium in Patients Undergoing Lumbar Spine Surgery
Lumbar vertebra surgery is one of the most common surgical procedures.Delirium is common in geriatric patients after lumbar spinae surgery.postoperative delirium usually occurs in the early postoperative period and delays patient…
- Trial name
- NCT05276648
- Testing
- CAM ICU test, MOCA test, brief pain test
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Aydin Adnan Menderes University
Pain Control
A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair
The purpose of this study is to identify a dose of intrathecal hydromorphone (opioid pain medicine) that optimizes pain control but minimizes side effects historically seen with this class of pain medications.
- Trial name
- NCT05552443
- Testing
- Hydromorphone 2.5 mcg/kg, Hydromorphone 2.75 mcg/kg, Hydromorphone 3 mcg/kg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Pain, Postoperative
Biopsychosocial Impact on Caregivers in Patients Undergoing Joint and Spine Surgery
The purpose of this study is to describe the biopsychosocial impact of caregivers in patients undergoing total knee arthroplasty, total hip arthroplasty, and cervical/thoracic/lumbar spine surgery.Defining such impacts may offer…
- Trial name
- NCT03059602
- Testing
- No specific treatment based intervention-health measurement instrument
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Metabolomics
Metabolomics of Intraoperative Saline and Balanced Crystalloid Infusion
Different crystalloids, namely 0.9% saline and balanced crystalloid may result in different metabolomic profile among surgical patients.
- Trial name
- NCT04137042
- Testing
- Saline, Balanced crystalloid
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- National Taiwan University Hospital
Obesity, Lumbar Spine Surgery
WoundVac in Obese Patients Undergoing Lumbar Surgery
This is an open label, randomized clinical trial of Closed-Incision Negative-Pressure Therapy to decrease post-operative wound complications in patients with BMI ≥35kg/m2 after posterior lumbar spine surgery.
- Trial name
- NCT03688438
- Testing
- Closed-Incision Negative-Pressure Therapy
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Norton Leatherman Spine Center
Cervical Spine Fusion
Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery
The goal of this randomized, double-blinded, clinical trial is to assess the benefit of administering a Multifidus Cervicis Plane (MCP) block compared to a sham block as a method of postoperative pain control in patients…
- Trial name
- MCP (NCT05996133)
- Testing
- Bupivacaine Hcl 0.25% Inj, Normal saline
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Hartford Hospital
Surgical Procedures, Operative
Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Spine Surgery
This study evaluates whether using information from a special arterial blood pressure monitor to guide how much fluid is given during surgery changes how long a patient stays in the hospital after the surgery.
- Trial name
- NCT01124474
- Testing
- goal directed therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Thoracolumbar Scoliosis
A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery
Scoliosis is a disease that involves lateral and/or rotational deformity of the spine and can affect up to 4% of the population.
- Trial name
- NCT02206685
- Testing
- Methadone, Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Opioid Dependence, Chronic Pain
Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery
The goal of this study is to determine whether comprehensive perioperative administration of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine can increase postoperative pain tolerance and reduce opiate consumption in…
- Trial name
- NCT04220489
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Jacques E. Chelly
Lumbar Spine Disease
Deep Neuromuscular Block on Postoperative Delirium in Lumbar Surgery
The effect of deep neuromuscular blockade (NMB) during spine surgery reduced postoperative pain and bleeding in recent studies. Therefore by reducing these two factors, which were the contributing factors for postoperative…
- Trial name
- NCT05453929
- Testing
- Rocuronium for deep NMB, Rocuronium for moderate NMB
- Where
- South Korea
- Volunteers
- 230 people
- Sponsor
- Korea University Guro Hospital
Pain, Postoperative, Opioid Use
Transcutaneous Auricular Neurostimulation After Lumbar Surgery
The purpose of this study, entitled "Delivering Transcutaneous Auricular Neurostimulation as an Adjunct Non-Opioid Pain Management Therapy for Patients Undergoing Lumbar Surgery", is to demonstrate whether transcutaneous…
- Conditions
- Pain, Postoperative, Opioid Use, Lumbar Spine Injury
- Trial name
- NCT06100172
- Testing
- Sparrow Ascent Transcutaneous Auricular Neurostimulation (tAN)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Texas Southwestern Medical Center
Hemorrhage, Cerebrovascular Accident
Antiplatelet Therapy Continuation in Spine Surgery - Its Effect on Postoperative Morbidity and Mortality
The objective of this study is to evaluate the safety of antiplatelet (APA)therapy continuation in patients undergoing lumbar spine surgery (laminectomy, discectomy and foraminotomy), and to gather evidence-based data regarding…
- Conditions
- Hemorrhage, Cerebrovascular Accident, Myocardial Infarction, Pulmonary Embolism
- Trial name
- NCT01006083
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Bone Diseases, Spine Cancer
Custom Pack in Spine Surgery
Recent evidence suggests the efficacy of "custom pack" procedure on the operators reduction time and on the contamination risk due to the opening of many sterile packs.
- Conditions
- Bone Diseases, Spine Cancer, Spine Osteoarthritis
- Trial name
- kit (NCT03050203)
- Testing
- custom pack, standard care
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Istituto Ortopedico Rizzoli
Spinal Diseases
Pilot Study to Evaluate Feasibility of DensiProbe Spine Assessing Bone Strength in Spinal Surgery
A new mechanical device was developed in order to provide the surgeon with intraoperative information about the mechanical strength of the cancellous bone within the vertebral body.
- Trial name
- DensiProbe (NCT01126385)
- Testing
- DensiProbe Spine
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation