Clinical trials: Patients Undergoing Valvular Heart Surgery
Valvular Heart Disease
Comparing Measurements of the Aortic Valve Taken During Surgery With Those Obtained Before Surgery Using Computed Tomography Scans, in Patients Undergoing Surgical Aortic Valve Replacement
This study aims to understand why there may be differences between the measurements of the aortic valve taken before and during surgery.
- Trial name
- SAVR-CT-AVA (NCT07125469)
- Testing
- The measurements taken from the CT scan will be used to determine the appropriate size for two types of theoretical Transcatheter Aortic Valve Replacement (TAVR) prostheses
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Maria Cecilia Hospital
Valvular Heart Disease Patients
The Effect of Remote Ischemic Postconditioning on Postoperative Renal Dysfunction in Patients Undergoing Valvular Heart Surgery
Ischemic reperfusion injury of cardiopulmonary bypass and postoperative renal dysfunction is a common problem which influence poor outcome in subjects undergoing valvular heart surgery.
- Trial name
- NCT02720549
- Testing
- remote ischemic postconditioning, valvular surgery with bypass
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Yonsei University
Complex Valvular Heart Surgery
Effect of Perioperative Iron Isomaltoside 1000 Administration on Transfusion Requirements in Patients Undergoing Complex Valvular Heart Surgery: a Randomized Clinical Trial
In complex cardiac surgery with prolonged cardiopulmonary bypass, allogeneic blood products transfusions are often necessary to control intraoperative and postoperative bleeding.
- Trial name
- NCT02862665
- Testing
- iron isomaltoside 1000 (Monofer®), normal saline 100 ml
- Where
- South Korea
- Volunteers
- 214 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Heart Valve Diseases
Is Myocardial Revascularization Really Necessary in Patients With ≥50-70% Coronary Stenosis Undergoing Valvular Surgery?
It is well documented in the literature that myocardial revascularization during valve surgery increases the risk of early mortality and morbidity.
- Trial name
- NCT05836467
- Testing
- Valvular interventions
- Where
- Italy
- Volunteers
- 77 people
- Sponsor
- Michele De Bonis
Coronary Artery Disease, Valvular Heart Disease
Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries
Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC).
- Trial name
- NCT01906918
- Testing
- IRPC, Remote preconditioning
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Campinas, Brazil
Coronary Artery Disease, Valvular Heart Disease
Strategies for Revascularization in Patients Undergoing Heart Valve Surgery With Concomitant Coronary Artery Disease
The purpose of this study is to determine whether, in patients undergoing elective valvular heart surgery, revascularization of concomitant coronary artery disease (CAD) guided by FFR (Fractional flow reserve) would be superior…
- Trial name
- SAVE-IT (NCT02173860)
- Testing
- FFR-guided surgical revascularization, Angio-guided surgical revascularization
- Where
- Portugal
- Volunteers
- 502 people
- Sponsor
- Portuguese Society of Cardiology
Valvular Heart Disease
Impact of Perioperative Shedding of the Endothelial Glycocalyx on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery.
Endothelial glycocalyx, the luminal structure of healthy vasculature, plays critical roles in regulation of inflammatory responses, vascular permeability, blood coagulation.
- Trial name
- NCT03197051
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Valvular Heart Disease, Coronary Artery Disease
Humanalbumin, Hydroxyethylstarch and Ringer Lactate During Cardiac Surgery
The aim of the study is to compare three different regimens for volume replacement during cardiac surgery, e.g. Albumin 5%, Hydroxyethylstarch 130/0.4 (HES) and Ringer-Lactate (RL).
- Trial name
- NCT01174719
- Testing
- volume replacement, Humanalbumin 5%
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Valvulopathy, Cardiac Surgery
Non-interventional Study Exploring the Composition of the Valvular Microbiota of Patients Undergoing Cardiac Surgery
The prevalence of aortic valve disease is increasing, with these valvulopathies present in half of individuals over the age of 65. Oberbach A.
- Conditions
- Valvulopathy, Cardiac Surgery, Microbiota
- Trial name
- BIOVALV (NCT07075601)
- Testing
- Take 1 ml of blood, DNA sequencing, Valve collection (healthcare waste)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Toulouse
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Patients Undergoing Valvular Heart Surgery
Associations of Postoperative Hemoglobin With AKI-AKD Trajectories
The investigators aimed to investigate the association of postoperative hemoglobin levels with acute kidney injury and acute kidney disease after valvular heart surgery, with a focus on acute kideny disease.
- Trial name
- NCT07907198
- Where
- South Korea
- Volunteers
- 4,230 people
- Sponsor
- Yonsei University
Heart Valvular Disease, Minimally Invasive Cardiac Surgery
SPSIP Block and Opioid Use After MICS
This prospective, randomized, controlled, single-center clinical study aims to evaluate the effectiveness of the Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in perioperative pain management among patients…
- Conditions
- Heart Valvular Disease, Minimally Invasive Cardiac Surgery, Postoperative Pain Management, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- SPSIPB-MICS (NCT07259824)
- Testing
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Valvular Heart Disease
Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Valvular Heart Surgery
One of the most important factor that affects the post op complication of the cardiac surgery is systemic inflammation. Valvular heart surgery requires cardiopulmonary bypass and cardioplegic arrest, which can arouse the…
- Trial name
- NCT02490644
- Testing
- Blood sampling
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Valvular Cardiac Surgery
A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery
High-dose statin therapy around the time of surgery, decreases inflammation in patients undergoing cardiac valve surgery, and thereby improves clinical outcomes.
- Trial name
- NCT01425398
- Testing
- Rosuvastatin
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Atrial Fibrillation
The Effect of Arrhythmia Surgery on Quality of Life in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
Atrial fibrillation (AF) is connected with an increased morbidity and mortality. In addition, quality of life is diminished due to palpitations, dyspnea, dizziness and syncope.
- Trial name
- NCT00886080
- Testing
- Pulmonary vein isolation using microwave energy
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Patients Undergoing Valvular Heart Surgery
Association Between Post-operative Anemia and Mortality After Valvular Heart Surgery
The investigators aimed to evaluate whether postoperative anemia can predict 1-year mortality after valvular heart surgery independent of preoperative anemia.
- Trial name
- NCT06647758
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Valvular Heart Disease
Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery
Patients scheduled for cardiac surgery are fragile. Hemodynamic fluctuation might be associated with adverse outcomes. Therefore, it is essential to keep hemodynamics stable during and after the induction period.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Arrythmia
- Trial name
- NCT05323786
- Testing
- The combined topical anesthesia induction group, The routine induction group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Atrial Fibrillation
The Value of add-on Arrhythmia Surgery in Patients With Atrial Fibrillation Undergoing Cardiac Surgery
The hypothesis being studied is that add-on arrhythmia surgery in patients with atrial fibrillation (AF) undergoing valvular or coronary surgery improves quality of life, is cost-effective, reduces perioperative and long-term…
- Trial name
- NCT01019759
- Testing
- pulmonary vein isolation
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Patients Undergoing Valvular Heart Surgery
Relationship Between Postoperative Tempeartive and Acute Kidney Injury
The investigators aimed to identify body temperature trajectory classes based on core temperature changes during the first 12 hours post-surgery and to explore their relationship with postoperative acute kidney injury in patients…
- Trial name
- NCT06647771
- Where
- South Korea
- Volunteers
- 3,274 people
- Sponsor
- Yonsei University