Clinical trials: Patients Undergoing Valvular Heart Surgery
Patients Undergoing Valvular Heart Surgery
A Prediction Model for 1-year Mortality After Valvular Heart Surgery
The investigators aimed to develop a predictive model for mortality incorporating nutritional, inflammatory, and perioperative factors in patients undergoing valvular heart surgery.
- Trial name
- NCT05833256
- Where
- South Korea
- Volunteers
- 2,046 people
- Sponsor
- Yonsei University
Heart Valve Diseases
Effect of Combined Remote Ischemic Preconditioning and Postconditioning on Acute Pulmonary Injury in Patients Undergoing Valvular Heart Surgery
Pulmonary dysfunction after cardiac surgery with CPB remains to be a problem complicating the postoperative course of the patients.
- Trial name
- NCT01427621
- Testing
- remote ischemic pre and postconditioning (RIPC)
- Volunteers
- 54 people
- Sponsor
- Yonsei University
Valvular Heart Disease
Impact of Positive End-expiratory Pressure on Hepatic Venous Flow
The purpose of this study is to determine the difference in the impact of moderate positive end-expiratory pressure (PEEP) on hepatic venous flow Doppler in patients undergoing cardiac surgery: conventional versus protective…
- Trial name
- NCT02700581
- Testing
- low PEEP conventional ventilation, moderate PEEP conventional ventilation, low PEEP protective ventilation
- Volunteers
- 15 people
- Sponsor
- Konkuk University Medical Center
Primary Valvular Heart Disease With Comorbid Coronary Artery Disease, Planned to Undergo Elective On-pump Valve Surgery Due to Primary Mitral and/or Aortic Valvular Heart Disease
Quantitative Flow Ratio (QFR) Guided Coronary Artery Bypass Grafting for Patients Undergoing Primary Valve Surgery With Concomitant Coronary Artery Disease
This is a multicenter, prospective, randomized, blinded, controlled clinical study in patients with planned primary valvular surgery and comorbid coronary artery lesions with diameter stenosis of ≥ 50%, to compare the…
- Trial name
- FAVOR IV-QVAS (NCT03977129)
- Testing
- QFR-guided strategy, CAG-guided strategy
- Where
- 12 sites in China
- Volunteers
- 792 people
- Sponsor
- Ruijin Hospital
Coronary Artery Disease, Valvular Heart Disease
Prehabilitation for Patients Undergoing Elective Cardiac Surgery
The objective of this clinical trial is to develop a novel rehabilitation model that, through the PRECICA program, will help to reduce perioperative and postoperative complications in the care process prior to planned cardiac…
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Chronic Thromboembolic Pulmonary Hypertension, Aortic Diseases
- Trial name
- PRECICA (NCT07704086)
- Testing
- Physical exercise, Educational program and respiration physiotherapy
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Hospital Universitario 12 de Octubre
Heart Valve Disease
Effect of Propofol on Renal Injury in Patients Undergoing Valvular Heart Surgery
Ischemia/reperfusion (I/R)-induced acute kidney injury is a serious complication affecting patient outcome following cardiovascular surgeries.
- Trial name
- NCT01384643
- Testing
- Propofol
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Yonsei University
Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery
High-sensitivity Troponin T in Acute Myocardial Infarction After Cardiac Valvular Surgery
A measurable degree of heart muscle tissue injury is expected in patients undergoing heart valvular surgery. The level of this injury can be measured by cardiac biomarkers in blood samples.
- Conditions
- Acute Myocardial Infarction, Disorder; Heart, Functional, Postoperative, Cardiac Surgery, Myocardial Infarction, Heart Valve Diseases
- Trial name
- NCT02518282
- Testing
- Serum levels of high-sensitivity troponin T, Twelve-lead ECGs, Transthoracic echocardiography (TTE)
- Where
- Spain
- Volunteers
- 800 people
- Sponsor
- University of Valladolid
Patients Undergoing Valvular Heart Surgery
Impact of Preoperative Nutritional Status on the Postoperative Mortality and Morbidity in Patients Undergoing Valvular Heart Surgery
The investigators investigated the clinical impacts of preoperative nutritional status on mortality in patients undergoing valvular heart surgery.
- Trial name
- NCT04307732
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Yonsei University
Patients With Elective Aortic Valve Replacement
Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery
The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium
- Trial name
- NCT01946087
- Testing
- Remote ischemic preconditioning at left upper arm, Control group
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Yonsei University
Aortic Valve Stenosis
Aortic Stenosis Associated Left Ventricular Remodeling - An Investigation of Genetic and Gender Specific Differences in 170 Patients Undergoing Aortic Valve Replacement Surgery
The goal of this study is to investigate the genetic and gender specific differences, in patients with low flow low gradient aortic stenosis and high flow high gradient aortic stenosis.
- Trial name
- SALVAGE (NCT05696145)
- Volunteers
- 170 people
- Sponsor
- Lisa Gundestrup
Valvular Heart Disease
Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery
Hyperlactatemia, occuring 10-20% in patients undergoing valvular heart surgery, is known to be associated with hemodynamic instability, organ dysfunction and increased postoperative morbidity and mortality.
- Trial name
- NCT01825720
- Testing
- (Glucose-Insulin-Potassium)GIK group, normal saline group
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Cardiac Surgery for Rheumatic Valvular Heart Disease, Renal Dysfunction
N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement
We aim to investigate the efficacy of N-acetylcysteine (NAC) to attenuate acute renal dysfunction in patients with rheumatic valvular heart disease undergoing single valve replacement.
- Trial name
- NCT01704482
- Testing
- N-acetylcysteine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Atrial Fibrillation, Valvular Heart Disease
Concomitant Surgical Atrial Fibrillation Ablation in Double Valve Replacement
Current European Society of Cardiology Guidelines recommend concomitant atrial fibrillation (AF) ablation for all symptomatic patients undergoing other cardiac surgeries, but the safety and potential benefits of concomitant…
- Trial name
- NCT03163836
- Testing
- double valve replacement, surgical ablation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Acute Kidney Injury
The Impact of Vitamin C on Postoperative Acute Kidney Injury in Risk Patients Undergoing Valvular Heart Surgery
In cases of cardiac surgery or sepsis which cause inflammation, oxidative stress, endothelial injury and vasoplegia, serum vitamin C concentration is sharply decreased.
- Trial name
- NCT04210453
- Testing
- Vitamin C, Control (Normal saline)
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Yonsei University