Clinical trials: Patients With Bipolar Disorders
Brain Voxel-based Morphometry in Mania
Brain Voxel-based Morphometry in Bipolar Mania
Bipolar disorder is a complex psychiatric disorder characterized by recurrent episodes of mania or hypomania and depression, and affects around one to three percent of the population .
- Trial name
- NCT03181698
- Testing
- Magnetic resonance imaging
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Bipolar Disorder
Aripiprazole in Patients With Acute Mania
The purpose of this trial is to test the safety \& efficacy of aripiprazole in patients with Bipolar Mania for a period of at least 12 weeks.
- Trial name
- NCT00095511
- Testing
- aripiprazole
- Where
- 38 sites in United States
- Volunteers
- 615 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Psychosis, Schizophrenia
Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders
This clinical trial is a single center, single dose study of the acute effects of intranasal insulin on energy metabolism and cognitive function in patients with schizophrenia, schizoaffective and bipolar disorders, compared and…
- Conditions
- Psychosis, Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder
- Trial name
- NCT03943537
- Testing
- Intranasal Insulin
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Bipolar Disorder
A Randomized, Open-label Trial of Long-acting Injectable Risperidone Versus Oral Antipsychotic Medication in Patients With Bipolar Disorder
The purpose of this study is to determine the safety and effectiveness of a long-acting injectable formulation of risperidone in stable bipolar patients randomly switched from their current add-on oral antipsychotic (olanzapine…
- Trial name
- NCT00246246
- Testing
- risperidone
- Volunteers
- 48 people
- Sponsor
- Janssen-Ortho Inc., Canada
Bipolar Disorder
Efficacy of Memantine add-on in the Treatment of Bipolar Disorder (Type I) Nonresponders or Partial Responders Patients
The main goal of this study is evaluate the efficacy of memantine association on the treatment with a previous combination of two drugs, including quetiapine with lithium or quetiapine with aripiprazole in young patients with…
- Trial name
- ARIQUELI-ME (NCT02630888)
- Testing
- Memantine
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- University of Sao Paulo
Bipolar Depression
Clinical Trial Evaluating ITI-007 (Lumateperone) as a Monotherapy for the Treatment of Bipolar Depression
The study will evaluate the efficacy and safety of ITI-007 (Lumateperone) in patients diagnosed with Bipolar I or Bipolar II disorder having a major depressive episode. The study will be conducted in two parts, Part A and Part B.
- Trial name
- NCT02600494
- Testing
- ITI-007 (Lumateperone)
- Where
- 55 sites in United States
- Volunteers
- 554 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Major Depressive Disorder, Bipolar Depression
The Study of Effectiveness of rTMS on Rumination and Anhedonia in Patients With Major Depressive Disorder
Rumination is significantly frequent in major depressive disorder. However, not a lot of studies have investigated the effects of repetitive transcranial magnetic stimulation on rumination and its electrophysiological correlates.
- Trial name
- NCT03468686
- Testing
- Bilateral rTMS, Unilateral rTMS (High frequency)
- Where
- Iran
- Volunteers
- 61 people
- Sponsor
- University of Tehran
Major Depression
Chronos: the Use of Chronobiological Treatment in Depression
The primary objective of the present study is to examine whether the combination of the antidepressant duloxetine and chronotherapeutic methods (including sleep deprivation, light therapy, and maintaining a regular sleep-wake…
- Trial name
- NCT00149110
- Testing
- Sleep deprivation, Light therapy, Diurnal rhythms
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Hillerod Hospital, Denmark
Bipolar I Disorder, Mania
A Cariprazine Study in the Prevention of Relapse in Bipolar I Disorder Patients Whose Current Episode is Manic or Depressive, With or Without Mixed Features
1) To evaluate the efficacy and safety of cariprazine at a target dose of 3.0 mg/day compared with placebo in prevention of relapse in patients with bipolar I disorder whose current episode (i.e.
- Conditions
- Bipolar I Disorder, Mania, Depression
- Trial name
- NCT03573297
- Testing
- Cariprazine
- Where
- 108 sites in United States, Bulgaria and 9 more
- Volunteers
- 901 people
- Sponsor
- AbbVie
Depression, Bipolar Disorder
Insulin Resistance in Patients With Major Depression
The purpose of this study is to study the relationship between insulin and glucose action and neuropsychological functioning (memory, attention, general thinking abilities) in persons with depression.
- Conditions
- Depression, Bipolar Disorder, Mood Disorders, Insulin Resistance
- Trial name
- NCT01106313
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Stanford University
Severe Mental Disorder, Schizophrenia
Community-based Mental Health Care for People With Severe and Enduring Mental Ill Health (RECOVER-E) Croatia
To contribute to improving the level of functioning and quality of life and mental health outcomes for people with severe and enduring mental ill health (SMI) (schizophrenia, bipolar disorder, depression) by adapting and up…
- Conditions
- Severe Mental Disorder, Schizophrenia, Bipolar Disorder, Severe Depression
- Trial name
- RECOVER-E (NCT03862209)
- Testing
- Community mental health team
- Where
- Croatia
- Volunteers
- 200 people
- Sponsor
- Klinički Bolnički Centar Zagreb
Bipolar Depression
Lurasidone - A 6-week Study of Patients With Bipolar I Depression (Add-on)
This clinical study is designed to test the hypothesis that lurasidone is effective, tolerable, and safe when added to treatment with lithium or Divalproex for the treatment of patients with bipolar I depression.
- Trial name
- NCT00868452
- Testing
- lurasidone + (lithium or divalproex)
- Where
- 71 sites in United States, Czechia and 8 more
- Volunteers
- 348 people
- Sponsor
- Sumitomo Pharma America, Inc.
Bipolar Affective Disorder; Remission in
Enhancing Resilience and Quality of Life in Bipolar Disorder Through Cognitive Behavioral Therapy
Bipolar disorder (BD) is a chronic and recurrent mood disorder characterized by alternating episodes of mania, depression, or mixed states, interspersed with periods of remission.
- Trial name
- NCT07748910
- Testing
- CBT-Based Psychological Resilience Enhancement Program for Individuals with BD
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Cumhuriyet University
Schizophrenia, Schizo Affective Disorder
Aripiprazole Once-Monthly in Hospitalized Patients (INITIATE)
To characterize the real-life clinical use of AOM in a hospitalized patient population with schizophrenia, schizoaffective disorder or BP1 requiring LAI therapy and evaluate its short-term effectiveness associated with its…
- Conditions
- Schizophrenia, Schizo Affective Disorder, Bipolar I Disorder
- Trial name
- INITIATE (NCT04907279)
- Testing
- Aripiprazole Once-Monthly (AOM)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Otsuka Canada Pharmaceutical Inc.
Affective Disorders, Unipolar Depression
Reducing the Rate and Duration of Re-ADMISsions Among Patients With Unipolar Disorder and Bipolar Disorder Using Smartphone-based Monitoring and Treatment - The RADMIS Trials
Unipolar and bipolar disorder combined account for nearly half of all morbidity and mortality due to mental and substance use disorders, and burden society with the highest health care costs of all psychiatric and neurological…
- Conditions
- Affective Disorders, Unipolar Depression, Bipolar Disorder
- Trial name
- RADMIS (NCT03033420)
- Testing
- A smartphone-based monitoring system including a) an integrated feedback loop between patients and clinicians and b) context-aware CBT modules
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Psychiatric Centre Rigshospitalet
Substance Use Disorder, Attention Deficit Disorder With Hyperactivity
tRNS in Anterior Cingulate Cortex Reduces Craving Over Dual Pathology Patients
The purpose of this study is to study the efficacy and security of noninvasive brain stimulation as a new approach for patients with Substance Use Disorders (SUDs) plus other psychiatric conditions like ADHD, Schizophrenia…
- Conditions
- Substance Use Disorder, Attention Deficit Disorder With Hyperactivity, Bipolar Disorder, Schizophrenia
- Trial name
- tRND&SUDs (NCT01876524)
- Testing
- Transcranial Random Noise Stimulation
- Where
- Spain
- Volunteers
- 225 people
- Sponsor
- Spanish Foundation for Neurometrics Development
Bipolar Disorder, Manic
Study of Lumateperone in the Acute Treatment of Patients With Bipolar Mania
This is a multicenter, randomized, double-blind, placebo-controlled, study in the acute treatment of patients with a diagnosis of bipolar I disorder with manic episodes or manic episodes with mixed features (bipolar mania), with…
- Trial name
- NCT06462586
- Testing
- Lumateperone
- Where
- 42 sites in United States, Bulgaria and 3 more
- Volunteers
- 354 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Depression, Alcoholism
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder.
- Conditions
- Depression, Alcoholism, Drug Abuse
- Trial name
- NCT02604277
- Testing
- Interpersonal and Social Rhythm Therapy (ISRT), Bipolar-Specific Cognitive Behavioral Therapy (CBT), Mindfulness-Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Emory University
Severe Mental Illness, Bipolar Disorder
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness
The goal of this clinical trial is to learn whether MoodSync, a mobile application for patients and their family caregivers, improves mood stability, medication adherence, daily functioning and early detection of relapse warning…
- Conditions
- Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- MoodSync (NCT07879131)
- Testing
- MoodSync, Standard care
- Where
- Bahrain
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Bipolar Disorder
Evaluation of Patient Characteristics and Treatment Approaches to Patients With Bipolar Disorder in Turkey
A registry study to identify the patient-diagnosis-treatment characteristic profile of patients with bipolar disorder in Turkey.
- Trial name
- NCT00660712
- Where
- 19 sites in Turkey (Türkiye)
- Volunteers
- 1,018 people
- Sponsor
- AstraZeneca