Clinical trials: Patients With Chronic Migraine
Migraine, Migraine With Aura
Ditan Acute tReatments: Effectiveness and Tolerability (DART)
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of lasmiditan as acute migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- DART (NCT05903040)
- Testing
- Lasmiditan
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University of Florence
Migraine, Migraine With Aura
Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine Patients
The purpose of this prospective and multicentric study is to evaluate the effectiveness and tolerability of atogepant as preventive migraine treatment in a cohort of episodic or chronic migraine patients.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura, Chronic Migraine
- Trial name
- STAR (NCT06414044)
- Testing
- Atogepant 60 mg
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Myofascial Trigger Points, Chronic Migraine Headache
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Chronic Migraine
Chronic migraine is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life.
- Conditions
- Myofascial Trigger Points, Chronic Migraine Headache, Greater Occipital Nerve Block
- Trial name
- NCT07347067
- Testing
- MTrPs Injection, Greater occipital nerve block group
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Episodic Migraine, Chronic Migraine
A Long-Term Safety and Tolerability Extension Study Evaluating Atogepant for the Prevention of Chronic or Episodic Migraine
This study will evaluate the Long-Term Safety and Tolerability of Atogepant 60 mg daily for the Prevention of Migraine in Participants with Chronic or Episodic Migraine
- Trial name
- NCT04686136
- Testing
- Atogepant 60 mg
- Where
- 116 sites in United States, Canada and 12 more
- Volunteers
- 596 people
- Sponsor
- AbbVie
Chronic Pain, Migraine Disability
Chronic Pain in the General Population of Chile
The present study seeks to follow up the cohort of adults representative of Chile's urban population whose levels of chronic pain were evaluated in March 2023 (baseline) as part of the Mental Health Thermometer (MHT) study.
- Conditions
- Chronic Pain, Migraine Disability, Neuropathic Pain, Fibromyalgia
- Trial name
- RDC (NCT06353100)
- Where
- Chile
- Volunteers
- 2,365 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Chronic Migraine Headache, Transcranial Direct Current Stimulation
TCDS for the Treatment of Chronic Migraine
Migraine affects 1 in 7 people worldwide, but for those suffering from chronic migraine there is a need for safe, effective and well tolerated treatments.
- Trial name
- NCT07214454
- Testing
- Transcranial direct current stimulation (Nettle device) 2mA stimulation for 20 minutes per day
- Volunteers
- 20 people
- Sponsor
- University College, London
Chronic Migraine
Laser Acupuncture for Chronic Migraine
A single-blind randomized controlled trial was conducted from October 2024 to May 2025. Chronic migraine patients were randomly assigned in a 1:1 ratio to receive either Laser acupuncture or sham treatment.
- Trial name
- LAFCM (NCT06219694)
- Testing
- Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taichung Veterans General Hospital
Chronic Migraine
Acceptance and Commitment Therapy to Improve Disability in Chronic Migraine
The goal of this clinical trial is to learn if the behavioral treatment called Acceptance and Commitment Therapy (ACT) works to improve disability in adults with chronic migraine.
- Trial name
- NCT06795867
- Testing
- acceptance and commitment therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Migraine, Migraine With or Without Aura
Evaluation of a Wearable Device for Acute Treatment of Migraines
The goal of this clinical trial is to determine the efficacy of a new, improved neuromodulation device that can be worn on the head and neck to relieve migraine pain.
- Conditions
- Migraine, Migraine With or Without Aura, Migraine, Acute, Migraine Headache
- Trial name
- NCT07015125
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Hinge Health, Inc
Chronic Migraine
A Study of Remote Electrical Neuromodulation for Acute Procedural Pain
The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine…
- Trial name
- NCT05730556
- Testing
- Nerivio ®
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Chronic Migraine
Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects With Chronic Migraine
An non controlled, long term, multi center investigation
- Trial name
- NCT05843721
- Testing
- KOS (Intranasal kinetic oscillation stimulation)
- Where
- 12 sites in Germany, Israel and 2 more
- Volunteers
- 98 people
- Sponsor
- Chordate Medical
Chronic Pain, Migraine
Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment
The investigators are evaluating the effects of a mind-body mobile application, in combination with a guided movement program, on the experience of chronic pain.
- Conditions
- Chronic Pain, Migraine, Chronic Pain Syndrome
- Trial name
- NCT07143396
- Testing
- Mind-body mobile application and guided movement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of the Fraser Valley
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Drug Resistant Epilepsy, Autism Spectrum Disorder
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD.
- Conditions
- Drug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, Pediatric
- Trial name
- NCT06309251
- Testing
- ketogenic diet (as per clinical practice)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Danone Nutricia SpA Società Benefit
Chronic Migraine as Defined by Criteria of International Headache Society (IHS)
Evaluation of the Prophylactic Efficacy of tDCS in Chronic Migraine
The purpose of this study is to determine whether TDCS is an effective prophylactic therapy of chronic migraine.
- Trial name
- Medis (NCT02120326)
- Testing
- Transcranial direct current stimulation of the motor cortex, simulation of Transcranial direct current stimulation of the motor cortex
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- University Hospital, Grenoble
Chronic Migraine
A Study With Intranasal Kinetic Oscillation Stimulation (KOS) in the Prevention of Chronic Migraine
An open pilot study, non-controlled, single center investigation.
- Trial name
- NCT05273151
- Testing
- KOS (Intranasal kinetic oscillation stimulation)
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- Chordate Medical
Chronic Migraine, Headache, Refractory Migraine
Occipital Nerve Stimulation in Chronic Migraine
The goal of this clinical trial is to compare two different types of occipital nerve stimulation (BurstDR (dorsal root) microdosing versus Tonic) in chronic refractory migraine.
- Trial name
- NCT07087678
- Testing
- Prodigy internal pulse generator occipital nerve stimulator
- Volunteers
- 40 people
- Sponsor
- University College, London
Chronic Daily Headache, Chronic Migraine
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal…
- Trial name
- NCT03231241
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Migraine, Episodic Migraine
A Study Evaluating Oral Atogepant for the Prevention of Migraine in Japanese Participants With Chronic or Episodic Migraine
This study will evaluate the long-term safety, efficacy and tolerability of atogepant 60 mg daily for the prevention of migraine in Japanese participants with chronic (CM) or episodic migraine (EM).
- Trial name
- JPN ATO OLE (NCT04437433)
- Testing
- Atogepant 60 mg
- Where
- 24 sites in Japan
- Volunteers
- 186 people
- Sponsor
- AbbVie