Clinical trials: Patients With Diabetes.
T2DM (Type 2 Diabetes Mellitus)
Efficacy and Safety of Berberine Ursodeoxycholate (HTD1801) in Patients With Type 2 Diabetes
The goal of this clinical study is to evaluate the efficacy and safety of Berberine Ursodeoxycholate (HTD1801) compared to placebo in patients with type 2 diabetes, inadequately controlled with diet and exercise alone.
- Trial name
- SYMPHONY-1 (NCT06350890)
- Testing
- HTD1801
- Where
- 56 sites in China
- Volunteers
- 408 people
- Sponsor
- Shenzhen HighTide Biopharmaceutical Ltd.
Hyponatremia, Hyponatremia With Extracellular Fluid Depletion
Hypotonic Hyponatremia: Criteria for the Correct Classification of Its Etiology and of Patient Volume Status
Hyponatremia is the most frequent electrolyte disorder encountered in clinical practice. The patient approach, however, is still problematic, above all because hyponatremia is a manifestation correlated to various pathological…
- Conditions
- Hyponatremia, Hyponatremia With Extracellular Fluid Depletion, Hyponatremia With Normal Extracellular Fluid Volume, Hyponatremia With Excess Extracellular Fluid Volume
- Trial name
- NCT04402190
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Diabetic Foot Ulcer
The Feasibility of a Facebook Group-based Program for Foot Self-management Support of Adults With Diabetes in Canada
The primary objective of this study is to examine the feasibility of a Facebook group-based program to support adults with diabetes in their foot self-care and prevention of foot ulcers. The sub-objectives are: 1.
- Trial name
- NCT04395521
- Testing
- Diabetic foot self-management support
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- Helen Obilor
Type 2 Diabetes Mellitus
Research on Changes in Intestinal Barrier Function and Gut Microbiome in Patients With Type 2 Diabetes After Duodenal Mucosal Resurfacing (DMR)
The aim of this study is to demonstrate the effects of duodenal mucosal resurfacing (DMR) on intestinal barrier function and gut microbiota when treating uncontrolled type 2 diabetes.
- Trial name
- DMR-IBF-GM (NCT06385704)
- Testing
- DMR Procedure
- Volunteers
- 100 people
- Sponsor
- Wang Siqi
Diabetes Mellitus, Type 2, Kidney Function Tests
The Study Will Evaluate Average 24-hr Sodium Excretion During Dapagliflozin Treatment in Patients With Type 2 Diabetes Mellitus With Preserved or Impaired Renal Function or Non-diabetics With Impaired Renal Function.
The purpose of this study is to evaluate how dapagliflozin mechanism of action is impacted by Type 2 Diabetes Mellitus status and kidney function
- Trial name
- DAPASALT (NCT03152084)
- Testing
- Dapagliflozin
- Where
- 4 sites in Netherlands, Sweden
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
Empagliflozin add-on to Insulin in Type 1 Diabetes Mellitus Over 28 Days
Placebo-controlled, double blind (triple-dummy technique), randomised parallel design comparison of three oral doses (2.5 mg, 10 mg, and 25 mg) of empagliflozin in patients with T1DM as adjunctive therapy to insulin over 28 days.
- Trial name
- NCT01969747
- Testing
- Empagliflozin medium, Empagliflozin low
- Where
- 2 sites in Austria, Germany
- Volunteers
- 75 people
- Sponsor
- Boehringer Ingelheim
Diabetic Neuropathies, Diabetes Mellitus, Insulin-Dependent
Treatment for Symptomatic Peripheral Neuropathy in Patients With Diabetes
The purpose of this protocol is to determine if an investigational drug known as LY333531 is effective in treating nerve malfunction in diabetes.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Non-Insulin-Dependent
- Trial name
- NCT00044408
- Testing
- Ruboxistaurin mesylate
- Where
- 35 sites in United States, Canada and 6 more
- Volunteers
- 200 people
- Sponsor
- Chromaderm, Inc.
Type 1 Diabetes Mellitus
A Phase III Study to Investigate if the Study Drug Diamyd Can Preserve Insulin Production and Improve Glycemic Control in Patients Newly Diagnosed With Type 1 Diabetes
The objective of DIAGNODE-3 is to evaluate the efficacy and safety of three intranodal injections of 4 μg of Diamyd also known as retogatein compared to placebo, along with oral Vitamin D supplementation, to preserve endogenous…
- Trial name
- DIAGNODE-3 (NCT05018585)
- Testing
- Recombinant human glutamic acid decarboxylase (rhGAD65) formulated in Alhydrogel®, Colecalciferol 2000 IU
- Where
- 60 sites in United States, Czechia and 7 more
- Volunteers
- 321 people
- Sponsor
- Diamyd Medical AB
Type 2 Diabetes, Atherosclerosis
The Copenhagen Insulin and Metformin Therapy Trial
Type 2 Diabetes Mellitus patients (T2DM) have an increased mortality rate due to macrovascular disease. The primary objective of the study is to evaluate the effect of an 18-month treatment with metformin versus placebo in…
- Conditions
- Type 2 Diabetes, Atherosclerosis, Arteriosclerosis
- Trial name
- CIMT (NCT00657943)
- Testing
- metformin, insulin detemir, insulin aspart + insulin aspart protamin
- Where
- 9 sites in Denmark
- Volunteers
- 415 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 2 Diabetes Mellitus
COVID-19 Lockdown Related Telemedicine for Type 2 Diabetes
At present, in order to cope with the global pandemic of the COVID-19 virus, governments have introduced corresponding measures, COVID-19 lockdown is one of the most important measures.
- Trial name
- NCT04723550
- Testing
- Hospital telemedicine management system, Usual care
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Wenwen Yin
Complications of Diabetes Mellitus
Clinical Study on Metabolic Surgery Compared to the Best Clinical Treatment in Patients With Type 2 Diabetes Mellitus
This is a prospective, open, randomized study involving 100 patients with microvascular complications of type 2 diabetes mellitus and obesity, who will undergo gastric bypass (Roux-en-Y gastric bypass ARM A) or receive best…
- Trial name
- MOMS (NCT01821508)
- Testing
- Clinical Treatment, Roux-En-Y gastric bypass surgery
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes
The goal of this clinical trial is to learn if knowing risk for diabetes can help adult patients with prediabetes take steps to get care and prevent diabetes.
- Trial name
- RISE (NCT07553325)
- Testing
- Risk Informed Shared Decision-Making Strategy (RISE), Low Touch Messaging Strategy (LTM)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Type 2 Diabetes
Role of BCAA in Glucose Homeostasis
This clinical trial study aims to evaluate the effects of prolonged NaPB treatment in a maximum of 20 patients with T2D. The primary objective is: to investigate if prolonged boosting of ing BCAA oxidation will substantially…
- Trial name
- NaPB2 (NCT05836350)
- Testing
- 4.8 g/m^2/day NaPB
- Volunteers
- 20 people
- Sponsor
- Maastricht University
Hypoglycemia, Diabetes Mellitus, Type 1
A Trial to Compare the Efficacy and Safety of 2 Different Batches of Subcutaneous Dasiglucagon in Patients With T1DM
A randomized, double-blind, crossover trial to compare the efficacy and safety of 2 different batches of subcutaneous dasiglucagon in patients with type 1 diabetes mellitus (T1DM)
- Trial name
- NCT03895697
- Testing
- dasiglucagon
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Zealand Pharma
Diabetes Mellitus, Type 2
Learning Modality in Individuals With Diabetes Incompatible
This study was planned to examine the effect of education based on learning styles in diabetic individuals who are incompatible with treatment, on treatment compliance and metabolic goals.
- Trial name
- NCT05007197
- Testing
- The Effect of Diabetes Education Based on Learning Modality
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
Meniere Disease
Vasopressin and V2 Receptor in Meniere's Disease
Summary: Some of sicknesses are well known to be provoked by inadequate adaptation to physical and/or psychogenic stress in their daily life.
- Trial name
- NCT00599560
- Testing
- vasopressin, V2 receptor and cyclic AMP
- Where
- Japan
- Volunteers
- 135 people
- Sponsor
- Osaka University
Diabetes Mellitus
Long-term Safety of Alogliptin in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the long-term safety of alogliptin, once daily (QD), following participation in 1 of 7 controlled studies in patients with type 2 diabetes mellitus.
- Trial name
- NCT00306384
- Testing
- Alogliptin
- Where
- 114 sites in United States, Argentina and 10 more
- Volunteers
- 3,323 people
- Sponsor
- Takeda
Type2 Diabetes
Study of Left Ventricular Function of Patients With Type 2 Diabetes Without Cardiovascular Disease
Type 2 diabetes is associated with high cardiovascular risk. Recent meta-analyzes suggest that the risk of hospitalization for heart failure in the diabetic is increased by 20% for each hemoglobin A1c point and that the risk of…
- Trial name
- DIACAR (NCT03736668)
- Testing
- echocardiography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Type 1 Diabetes Mellitus
Assessment of Quality of Life and Satisfaction With Medical Care of Pediatric Type 1 Diabetes Mellitus Patients
The purpose of this study is to evaluate the change score for the PedsQL short form Diabetes and Core Modules and the Patient Assessment of Chronic Illness Care measured at baseline (before changing care delivery models) and 12…
- Trial name
- NCT00450489
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City