Clinical trials: Patients With Major Depressive Disorder
Major Depressive Disorder
Electrophysiologic Parameters and Biomarkers Predicting Treatment Response in Patients With Major Depressive Disorder
To explore electrophysiologic parameters and biomarkers predicting treatment response of patients with major depressive disorder To explore electrophysiologic parameters and biomarkers predicting suicide risk of patients with…
- Trial name
- NCT01997580
- Testing
- escitalopram
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Depression
The Impact of Psychological Interventions on Psychometric and Immunological Measures in Patients With Major Depression
The objective of this study is to compare the impact of i) Cognitive Behavioral Therapy (CBT) combined with exercise, ii)CBT combined with euthymic therapy, and iii) 'Cognitive Behavioral Analysis System of Psychotherapy' (CBASP)…
- Trial name
- NCT01464463
- Testing
- CBT - active, CBT - euthymic, CBASP
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Healthy, Involutional Depression
Bone Mineral Density in Women With Major Depression
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than…
- Conditions
- Healthy, Involutional Depression, Osteoporosis
- Trial name
- NCT00001413
- Where
- United States
- Volunteers
- 585 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depressive Disorder, Major
Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
The main objective was to compare the differences of PSG parameters and plasma melatonin levels before and after treatment with escitalopram for 8 weeks.
- Trial name
- NCT04013464
- Testing
- Escitalopram
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
Major Depressive Disorder
Acupuncture for Patients With Major Depressive Disorder
Several studies investigating acupuncture for major depressive disorder (MDD) have been carried out. However, investigators found the results were in high heterogeneity and poor methodological quality.
- Trial name
- NCT05106868
- Testing
- acupuncture
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Major Depressive Disorder
The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?
The purpose of this study is to determine whether memantine will enhance the therapeutic of effect on depression and prevent memory and other cognitive problems caused by ECT.
- Trial name
- ECTAug (NCT00988663)
- Testing
- memantine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jerrry L Lewis
Vitamin b6 Level & Depression
Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder
Estimation of vitamin B 6 levels in diagnosed major depressive disorder patients and their relation to the severity of the disease
- Trial name
- NCT05649293
- Testing
- measure vitamin b6 in serum
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Assiut University
Depressive Disorder, Major
Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders
This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression.
- Trial name
- NCT00097175
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Major Depressive Disorder
Switching From SSRI to Desvenlafaxine on Cognitive Functioning
Given the importance of cognitive function on depressed patients' treatment outcome and return to premorbid functioning, the effect of antidepressant drugs on cognition has become of primary concern.
- Trial name
- NCT03432221
- Testing
- Desvenlafaxine
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Malignant Brain Tumors
PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors
The purpose of this pilot study is to investigate the feasibility of an early palliative care intervention (PRESENCE: Providing Resources Education, Support, and Enabling New brain tumor patients to Cope Effectively) and the…
- Trial name
- NCT01652768
- Testing
- Research Questionnaires, Palliative Care Team, Educational Information Session for Patients and Caregivers
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Depressive Disorder, Major
Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients
The main objective of this study is to confirm the existence of risky decision making in a non strategic situation (Iowa Gambling Task) and a deficit of decision making in social situations, linked to greater sensitivity to…
- Trial name
- SPAD (NCT02737540)
- Where
- 2 sites in France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Perinatal Depression
Early Detection of Perinatal Depression With Wearable Technology
The goal of this feasibility study is to learn whether wearable devices and self-report surveys can help researchers better understand changes in mood during pregnancy and after birth in young pregnant individuals with a history…
- Trial name
- BLUESMAPPED (NCT07784244)
- Testing
- Oura Ring (Photoplethysmography-based wearable ring), EmbracePlus Watch (Electrodermal activity wristband sensor)
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital
Depression
Imaging the Nucleus Accumbens in Major Depressed Patients 'Treated With Pramipexole
We hope to learn how a brain circuit that is important to the understanding of depression, anhedonia and positive affect responds to a novel pharmaceutical treatment for depression and related symptoms.
- Trial name
- NCT01066897
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stanford University
Panic Disorder, Posttraumatic Stress Disorder
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder
The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD).
- Conditions
- Panic Disorder, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT00025974
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Obstructive Pulmonary Disease, End-of-Life Fear
End-of-Life Fear in Patients With End-Stage Lung Disease (COPD)
The aim of the study is to develop an interview to ask patients with COPD about their fear of death and dying, their needs and wishes at the end-of-life.
- Conditions
- Chronic Obstructive Pulmonary Disease, End-of-Life Fear, Fear About Death and Dying, Depression
- Trial name
- NCT00792974
- Testing
- A brief psycho-educational intervention
- Where
- 2 sites in Germany
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Depressive Disorder, Major
Objective Diagnostic Markers and Personalized Intervention in MDD Patients
Major depressive disorder (MDD) is one of the most common psychiatric disorders, with high recurrence rate, suicide rate and disability rate.
- Trial name
- NCT02023567
- Testing
- SSRIs
- Where
- 9 sites in China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Peking University
Depression, Major Depressive Disorder
Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression
Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD.
- Conditions
- Depression, Major Depressive Disorder, Cardiovascular Disease, Coronary Artery Disease
- Trial name
- NCT00818506
- Where
- Denmark
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Major Depression
The Effect of Exercise on Depressive Symptoms in Unmedicated Patients
This trial investigates the biological effect of exercise training on depression. Participants will randomly be allocated to either a aerobic exercise group performing exercise on stationary bikes or a group performing low-impact…
- Trial name
- DEMOII (NCT00695552)
- Testing
- Aerobic exercise, Low impact exercise
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Mood Disorder
Does Sleep Quality Change After Switch From Wellbutrin SR to Wellbutrin XL in Patients With Major Depressive Disorder?
Wellbutrin (bupropion) is an effective antidepressant (Thase, M 2005). It exists in instant release (IR), sustained release (SR) and extended release (XL) forms. The IR formulation was never approved for use in Canada.
- Trial name
- NCT00616915
- Testing
- Wellbutrin XL
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
Psychiatric Disorder, Depression
Investigating Neural Response Variability as a Single-patient Predictor of Successful CBT in Clinical Psychiatry
Many psychiatric patients are not sufficiently improved by current interventions. Functional magnetic imaging brain imaging (fMRI) has proven to be a promising method for predicting treatment outcomes in psychiatric treatment.
- Conditions
- Psychiatric Disorder, Depression, Anxiety Disorders, Insomnia
- Trial name
- TreVar (NCT04191811)
- Testing
- Internet-delivered cognitive behavioral therapy for major depressive disorder, Internet-delivered cognitive behavioral therapy for insomnia, Internet-delivered cognitive behavioral therapy for social anxiety disorder
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet