Clinical trials: Patients With Metabolic Syndrome
Prader Willi Syndrome, Adrenal Insufficiency
Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi Syndrome
The purpose of this study is to determine presence of central adrenal insufficiency in children with Prader Willi Syndrome using low dose (1 mcg) ACTH stimulation test compared to results of overnight metyrapone test.
- Trial name
- NCT02368379
- Testing
- Low dose (1 mcg) ACTH stimulation test, Overnight metyrapone test
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Gitelman Syndrome, Potassium Depletion
Monocentric STUDY, Randomised Double Blinded (Healthy Subjects, or Transversal (Patients With Gitelman Syndrome)
Progesterone is needed to permit adaptation of the kidney to limit potassium loss in the urines. The investigators wonder whether progesterone or other adrenal hormon play the same role.
- Trial name
- DEPROGE (NCT02297048)
- Testing
- Potassium depletion
- Where
- France
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Myeloproliferative Disorders, Fanconi Anemia
Research Study in Healthy Volunteers of Patients With Fanconi Anemia, Myeloproliferative Disorders, or Myeloma
RATIONALE: Analyzing tissue and blood samples from healthy volunteers or patients with Fanconi anemia, myelodysplasia, myeloproliferative disorders, or myeloma in the laboratory may help doctors learn more about the causes of…
- Conditions
- Chronic Myeloproliferative Disorders, Fanconi Anemia, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic/Myeloproliferative Neoplasms
- Trial name
- NCT00900055
- Testing
- microarray analysis, polyacrylamide gel electrophoresis, polymerase chain reaction
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Celiac Disease, Gluten Sensitivity
RCT: Effect of Late vs Early Introduction of Gluten-free Oats on Patients With Newly Diagnosed Celiac Disease.
The investigators are conducting a pilot study to investigate the impact of late compared to early introduction of gluten-free oats on gut symptoms, nutrition status, celiac activity and quality of life in patients with a recent…
- Conditions
- Celiac Disease, Gluten Sensitivity, Gluten Allergy, Gluten Enteropathy
- Trial name
- NCT05803408
- Testing
- gluten-free oats
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
T-Cell Immune Deficiency Diseases, Severe Combined Immunodeficiency
IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency
This is a multi-institution, single arm, non-randomized pilot study coordinated by the Pediatric Blood and Marrow Transplant Consortium.
- Trial name
- NCT00228852
- Testing
- Busulfan, Fludarabine and ATG
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
NOMID, DIRA
Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)
Background: Some diseases cause chronic inflammation with intermittent flares in the body. These are called autoinflammatory diseases. They can cause fevers, rashes, ulcers, and other problems.
- Conditions
- NOMID, DIRA, NLRC4-MAS, SAVI
- Trial name
- NCT02974595
- Where
- United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Metabolic Syndrome, Coronary Heart Disease
Cognition and Exercise Training
The aim of study is to investigate the impact of two different training modalities (high intensity interval training (HIIT) versus moderate intensity continuous exercise training (MICET) on cognitive performance, cerebral…
- Conditions
- Metabolic Syndrome, Coronary Heart Disease, Chronic Heart Failure
- Trial name
- COGNEX-2 (NCT01906957)
- Testing
- high intensity interval training (HIIT), moderate intensity continuous exercise training
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Psoriasis Vulgaris, Psoriatic Arthritis
Metabolic Syndrome in Psoriasis and Psoriatic Arthritis and Correlation With Serum Omentin and Visfatin Levels
In this study, the prevalence of metabolic syndrome in psoriatic and psoriatic arthritis patients as well as the parameters of metabolic syndrome will be examined.
- Conditions
- Psoriasis Vulgaris, Psoriatic Arthritis, Metabolic Syndrome
- Trial name
- NCT03932110
- Testing
- omentin, visfatin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Hypothalamic Obesity, Prader-Willi Syndrome
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
The purpose of this study is to evaluate the safety, tolerability, and PK of RM-718 in healthy subjects with obesity and in patients with MC4R Pathway Impairment
- Conditions
- Hypothalamic Obesity, Prader-Willi Syndrome, PWS
- Trial name
- NCT06239116
- Testing
- Part C: RM-718, Part D: RM-718
- Where
- 7 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Sepsis, Septic Shock
Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients
Alterations of acid-base equilibrium are very common in critically ill patients and understanding their pathophysiology can be important to improve clinical treatment.
- Conditions
- Sepsis, Septic Shock, Critical Illness, Respiratory Acidosis
- Trial name
- ENTERPRISE (NCT03966664)
- Testing
- In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in isolated plasma., In vitro determination the dissociation constant (Ka) and total amount of non-volatile buffers (Atot) in whole blood, Biomolecular analysis of plasma proteins.
- Where
- 2 sites in Czechia, Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
MELAS Syndrome
Responses to Influenza Vaccine in Patients With Mitochondrial Disorders (MELAS)
This pilot clinical study evaluated the safety and metabolic responses to a licensed inactivated seasonal influenza vaccine (TIV) in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS)…
- Trial name
- NCT01831934
- Testing
- Fluzone®
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Euthyroid Condition
the Association Between Thyroid Hormones and Metabolic Components in Patients With Obesity
This study collected clinical data of obese patients with euthyroid function, including age, gender, height, weight, BMI, waist circumference, blood pressure, fasting blood sugar, blood sugar 2 hours after sugar load, fasting…
- Conditions
- Obesity, Euthyroid Condition, Metabolic Syndrome
- Trial name
- NCT04599374
- Testing
- no intervention
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Polycystic Ovary Syndrome
The Study of Polycystic Ovary Syndrome(PCOS) With Gene and Questionnaire
Polycystic ovary syndrome (PCOS) is an extremely common disorder in women of reproductive age. Diagnosis of PCOS is principally based on clinical and physical findings.
- Trial name
- NCT01114659
- Where
- Taiwan
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Metabolic Syndrome
Effect of Baduanjin Exercise on Metabolic Syndrome Patients
Pre/posttest randomized control trial design. In this study all patients will be randomly assigned into two groups (30 in each group) : Group A will do baduanjin exercise in addition to traditional medical treatment.
- Trial name
- NCT06179810
- Testing
- Baduanjin exercise
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Obesity, Hyperlipidemia
Lepticore in Metabolic Syndrome and Weight Loss
Metabolic syndrome is directly related to obesity. This study investigated the use of a plant based formulation to improve on the condition of people with metabolic syndrome.
- Conditions
- Obesity, Hyperlipidemia, Hyperglycemia
- Trial name
- NCT01046968
- Testing
- Lepticore
- Where
- Cameroon
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Yaounde 1
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Psoriasis, Metabolic Syndrome
Methotrexate Versus Secukinumab Safety in Psoriasis Patients With Metabolic Syndrome
A prospective, controlled, open trial in psoriasis patients with metabolic syndrome, candidate to methotrexate or secukinumab was conducted between January 2019 and May 2020.
- Trial name
- NCT04469829
- Testing
- Secukinumab, Methotrexate
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Celiac Disease in Children, Celiac Disease
Development of CELIAC-Q KIDS: A Patient-Reported Outcome Measure for Pediatric Celiac Disease
A multicentre, prospective observational study to develop the CELIAC-Q KIDS patient reported outcome measure for children and adolescents with celiac disease.
- Conditions
- Celiac Disease in Children, Celiac Disease, Patient-reported Outcome Measures
- Trial name
- NCT05548166
- Testing
- Interview and scale development
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Long QT Syndrome
Metabolism of Patients With Genetically Caused Cardiac Arrhythmia
Loss-of-function mutations in voltage-gated potassium channels cause long QT syndrome (LQTS) due to a prolonged cardiac repolarisation phase.
- Trial name
- NCT02775513
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fanconi Anemia
Gene Function in Bone Marrow Cells From Patients With Fanconi Anemia and From Healthy Participants
RATIONALE: Studying samples of bone marrow from patients with Fanconi anemia and from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to Fanconi…
- Trial name
- NCT00896740
- Testing
- microarray analysis, biopsy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute