Clinical trials: Patients With Speech Disorders, open to volunteers
Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis)
Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)
Eighteen million people worldwide are affected by speech disorders. Locked-in syndrome (LIS) represents the most extreme form of communication disability resulting from motor impairment.
- Trial name
- SpeechBCI (NCT07698496)
- Testing
- Chronic speech BCI
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Primary Progressive Aphasia(PPA)
Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia
This is a monocenter randomized controlled clinical trial with cross-over arm - assessor blinded. The aims is investigating the effects of the speech language therapy (SLT) alone vs SLT + non-invasive brain stimulation (STIM)…
- Trial name
- NCT06921265
- Testing
- Training with Speech Language Therapy, Standard rTMS, Targeted rTMS
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Aphasia, Stroke
Effect of Anomia Rehabilitation Combined With Metacognitive Training in Patients With Chronic Vascular Aphasia
The postulate of this study is that rehabilitation combining linguistic and metacognitive training will result in a significant improvement in language performance correlated with changes in functional cerebral connectivity…
- Trial name
- METALEX (NCT06930131)
- Testing
- Semantic rehabilitation
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Hearing Loss, Bilateral or Unilateral
Effectiveness of Speech Therapy for Lip-reading in Patients With Hearing Aids: SCED Study
This study aims to investigate whether lip reading rehabilitation improves viseme recognition in individuals with hearing impairments who use hearing aids.
- Trial name
- SCEDuLL (NCT07028658)
- Testing
- Speechreading training
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Dentofacial Abnormalities, Dentofacial Deformities
Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses
The investigators are studying how speech is effected by jaw and tooth position in jaw surgery patients. Eighty percent of our jaw surgery patients have speech pathologies, compared to five percent of the general population, but…
- Conditions
- Dentofacial Abnormalities, Dentofacial Deformities, Dentofacial Anomalies, Including Malocclusion, Malocclusion
- Trial name
- OSP (NCT04117360)
- Testing
- Orthognathic surgery and Orthodontics
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
GERD
Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy
Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia.
- Trial name
- LAS (NCT07634614)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Stroke and Aphasia
The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers
The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their…
- Trial name
- NCT02328573
- Testing
- Communal singing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis
Tongue-strengthening Exercises in People With ALS.
This study is testing a tongue exercise program for people living with ALS to see if it can help support speech and swallowing. All participants will receive the treatment, and researchers will measure changes over time by…
- Trial name
- NCT07295990
- Testing
- Isometric Lingual Strength Exercises
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nova Southeastern University
Aphasia, Stroke
Effects of Recursive Self-feedback on Speech Production in Aphasia
The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia).
- Trial name
- NCT06323629
- Testing
- Adaptive recursive self-feedback procedure, Non-adaptive recursive self-feedback procedure
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of South Florida
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia
EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION ON NAMING IN APHASIC PATIENTS WITH ACUTE ISCHEMIC STROKE
The use of transcranial direct current stimulation (tDCS) for the management of deficits developed in stroke is a relatively new type of management option.
- Conditions
- Acute Ischemic Cerebrovascular Disease, Post Stroke Aphasia, Aphasia Following Cerebral Infarction, Aphasia, Acquired
- Trial name
- NCT07496645
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Bone Conduction, Hearing Loss, Conductive
Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients
The goal of this interventional study is to confirm the safety and performance of the latest generation Osia System and to examine its benefits compared to the Baha Connect System in adults with mixed or conductive hearing loss…
- Conditions
- Bone Conduction, Hearing Loss, Conductive, Hearing Loss, Mixed
- Trial name
- OSIRIS (NCT07130136)
- Testing
- Cochlear™ Osia® System, Cochlear™ Baha® System
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Cochlear
Dysphagia
Innovative Patient-partner-guided Virtual Group Speech Pathology Intervention Model in Head and Neck Cancer
This project aims to study an innovative intervention, the eG2 Intervention, developed by speech-language pathologists at the Centre hospitalier de l'Université de Montréal to improve therapeutic adherence and prevent dysphagia…
- Trial name
- NCT05621889
- Testing
- virtual group speech therapy intervention guided by a patient partner
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cerebral Palsy
Speech Therapy Settings in Cerebral Palsy
Cerebral palsy (CP) is a common neurodevelopmental disorder affecting motor functions, cognition, and communication skills in children.
- Trial name
- NCT07784790
- Testing
- Hospital-based Speech and Language Therapy, Home-based Speech and Language Therapy
- Volunteers
- 52 people
- Sponsor
- Selcuk University
Aphasia, Malignant Brain Tumor
Listen Aphasia Pilot Study
This is a feasibility and pilot study to refine and test LISTEN, an AI-based augmentative and alternative communication (AAC) smartphone app, integrated into the patient's personal electronic device, to augment and facilitate…
- Trial name
- LISTEN (NCT07732140)
- Testing
- LISTEN (AI-based AAC smartphone app)
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Dana-Farber Cancer Institute
Patients With Speech Disorders
AI-Based Speech Intelligibility Assessment: Efficacy & Reliability
compare the auditory-perceptual assessment conducted by speech-language pathologists using the U-TAP with the assessment performed via the AI solution (Blings) program in patients with speech disorders, and to evaluate the…
- Trial name
- AI Solution (NCT07347782)
- Volunteers
- 40 people
- Sponsor
- Pusan National University Yangsan Hospital
Developmental Delays
Empower EI: Comparing Early Intervention Approaches to Improve Communication in Toddlers With Developmental Delays
This study is testing three ways to deliver Early Intervention (EI) services for toddlers with developmental disabilities (DD). Children enrolled in EI speech therapy will receive one of three approaches: 1.
- Trial name
- NCT07227974
- Testing
- Therapist-Delivered Early Intervention Approach, Caregiver Coaching Early Intervention Approach, Parents Taking Action
- Where
- United States
- Volunteers
- 1,269 people
- Sponsor
- Northwestern University
Stuttering, Adult
Lumateperone in the Treatment of Stuttering, Childhood Onset Fluency Disorder
The primary objective of this study is to evaluate the efficacy and tolerability of Lumateperone in reducing stuttering symptoms. The following scales and samples will be collected for clinical and functional outcomes.
- Trial name
- NCT07734103
- Testing
- Lumateperone (ITI-007)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- CSTrials Inc.
Lynch Syndrome, Lynch Syndrome I
Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
Lynch syndrome (OMIM #120435) is the most common dominantly inherited colorectal cancer syndrome with an estimated prevalence of 1:270 individuals.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, Lynch Syndrome I (Site-specific Colonic Cancer)
- Trial name
- LYNX-EYE (NCT06708429)
- Testing
- LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)
- Where
- 5 sites in United States, Italy
- Volunteers
- 300 people
- Sponsor
- San Raffaele University