Clinical trials: Patients With Speech Disorders
Stroke, Aphasia
Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke.
- Trial name
- MOTOLANG-AVC (NCT05776368)
- Testing
- Syntactic comprehension battery (BCS), Montreal Cognitive Assessment (MOCA), Purdue Pegboard Test
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Aphasia, Stroke, Acute
tDCS to Treat Subacute Aphasia
This study proposes to use transcranial direct current stimulation (tDCS), a technique by which a very small electrical current (2 mA) is applied to the scalp, along side speech therapy in patients with subacute stroke and…
- Trial name
- NCT04048668
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- United States
- Sponsor
- University of Pennsylvania
Primary Tauopathies, Corticobasal Degeneration Syndrome
BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different…
- Conditions
- Primary Tauopathies, Corticobasal Degeneration Syndrome, Frontotemporal Lobar Degeneration With Tau Inclusions, MAPT Mutation Carriers, Symptomatic
- Trial name
- TauBasket (NCT03658135)
- Testing
- BIIB092
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Measurement, Psychological Stress, Speech Disorders
The Mere-measurement Effect of Patient-reported Outcomes
The use of patient-reported outcome (PROs) have become increasingly commonplace across many healthcare settings over the past two decades. The value of PROs is now acknowledged by healthcare providers and patients alike.
- Conditions
- Measurement, Psychological Stress, Speech Disorders, Assessment, Self
- Trial name
- NCT06443073
- Testing
- Patient-reported outcomes for speech disorders: positive
- Where
- Austria
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Locked in Syndrome, ALS (Amyotrophic Lateral Sclerosis)
Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for Speech Rehabilitation in Patients With Locked-in-syndrome (LIS)
Eighteen million people worldwide are affected by speech disorders. Locked-in syndrome (LIS) represents the most extreme form of communication disability resulting from motor impairment.
- Trial name
- SpeechBCI (NCT07698496)
- Testing
- Chronic speech BCI
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Grenoble
Aphasia
Speeded Anomia Treatment in Chronic Post-stroke Aphasia
The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia.
- Trial name
- NCT05512884
- Testing
- Speeded anomia therapy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Stroke and Aphasia
The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers
The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their…
- Trial name
- NCT02328573
- Testing
- Communal singing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Depression, Depressive Symptoms
ICU Family Communication Study
The purpose of this study is to improve care in the Intensive Care Unit (ICU) by focusing on communication with family members of patients who are too sick to make decisions about their own care while they are in the ICU.
- Conditions
- Depression, Depressive Symptoms, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT00720200
- Testing
- Facilitator-Based intervention, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 593 people
- Sponsor
- University of Washington
Stroke, Aphasia
Functional Neuroimage in Assessment of Post-stroke Aphasia
The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear.
- Trial name
- NCT02120508
- Testing
- rTMS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- vghtpe user
Aphasia, Stroke
Exploratory Evaluation of the Digital Therapeutic Device Zenicom for Subacute Stroke Aphasia
Clinical Trial Title A Multicenter, Single-Blind, Prospective, Randomized, Exploratory Clinical Trial to Evaluate the Safety and Efficacy of the Digital Therapeutic Device 'Zenicom' for Improving Aphasia in Patients with Subacute…
- Trial name
- NCT07397923
- Testing
- Zenicog, Conventional Speech Therapy
- Where
- 3 sites in South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Bundang Hospital
Sensorineural Hearing Loss, Bilateral
Comparison in New Cochlear Implanted Subjects of a Tonotopy-based Fitting With or Without Fine Structure Coding
Brief Summary: Main objective: Comparison of a tonotopy based fitting strategy (TFS) with fine structure coding to a tonotopy based fitting strategy without fine structure coding (TnoFS) for speech perception in noise.
- Trial name
- NCT05754918
- Testing
- TnoFs then TFS (Cochlear implant), TFS then TnoFS (Cochlear implant)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Pedophilia, Hebephilia
Talking for Change: Secondary Prevention of Child Sexual Abuse Perpetration
The goal of this patient preference randomized controlled trial is to investigate the efficacy of Talking for Change (TFC), an intervention for the secondary prevention of child sexual abuse and exploitation (CSA) perpetration.
- Conditions
- Pedophilia, Hebephilia, Child Sexual Abuse, Program Evaluation
- Trial name
- NCT07001735
- Testing
- Talking for Change Group Psychotherapy, Healthier Me: Managing Risk and Stress in Everyday Life
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Hearing Loss, Bilateral or Unilateral
Effectiveness of Speech Therapy for Lip-reading in Patients With Hearing Aids: SCED Study
This study aims to investigate whether lip reading rehabilitation improves viseme recognition in individuals with hearing impairments who use hearing aids.
- Trial name
- SCEDuLL (NCT07028658)
- Testing
- Speechreading training
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Institut Pasteur
Head Neck Cancer, Swallowing Disorders
Swallowing Intervention During Radiochemotherapy on Head and Neck Cancer
General Objective: To evaluate the swallowing results of speech pathologist rehabilitation of advanced oropharynges, larynx and hypopharynx cancer patients during neoadjuvant chemotherapy and radiotherapy concomitant to…
- Trial name
- Swallowing-1 (NCT02075385)
- Testing
- pre, during and pos-treatment swallowing exercises
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Barretos Cancer Hospital
Mild Cognitive Impairment, Dementia
Validation of acceXible's Automated Speech Analysis Method for the Early Detection and Monitoring of Patients With Mild Impairment or Dementia in Primary Care
Dementia, especially dementia caused by Alzheimer's disease, is considered one of the most severe health problems of our time. It is currently known that the disease begins many years before clinical symptoms appear.
- Trial name
- NCT05380297
- Testing
- Speech analysis
- Where
- Spain
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Accexible
Dysphagia, Oropharyngeal, Parkinson Disease
Benefit From the Chin Down Maneuver in the Swallowing Performance and Self-perception of Parkinson's Disease Patients
Objective: To verify the effectiveness of chin-down posture maneuver in swallowing therapy for Parkinson's disease (PD).
- Conditions
- Dysphagia, Oropharyngeal, Parkinson Disease, Speech Therapy, Orientation
- Trial name
- NCT02973698
- Testing
- chin-down posture maneuver, Orientations about swallowing, Control
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Aphasia, Aphasia, Anomic
Speech Therapy and Repetitive Transcranial Magnetic Stimulation Therapy in Post-stroke Anomic Aphasia
The aim of the study is to observe the effects of speech therapy and transcranial magnetic stimulation therapy in patients who develop anomic aphasia after stroke.
- Conditions
- Aphasia, Aphasia, Anomic, Stroke
- Trial name
- NCT04625790
- Testing
- Repetitive transcranial magnetic stimulation, Speech therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ege University