Clinical trials: Patients With Total Knee Arthroplasty
Hip Osteoarthritis, Knee Osteoarthritis
What Matters to Patients With Severe Hip or Knee Osteoarthritis?
This clinical trial aims to investigate if shared decision-making, and the use of an in-consultation patient decision aid (PtDA), increases the decisional quality and therefore treatment satisfaction and outcome of patients with…
- Trial name
- PATI-Project (NCT05972525)
- Testing
- Shared decision-making supported by an in-consultation PtDA to patients with severe osteoarthritis in their hip or knee
- Where
- 3 sites in Denmark
- Volunteers
- 615 people
- Sponsor
- Vejle Hospital
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Knee Osteoarthritis
Dietary Supplementation With Blueberry in OA
Osteoarthritis is a painful long term joint condition that is associated with poor quality of life. There are no treatments to prevent it. Inflammation is one cause of osteoarthritis. This inflammation is complex.
- Trial name
- NCT05784545
- Testing
- Blueberry powder supplement, Maltodextrin supplementation
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Exeter
Arthroplasty
Long-term Evaluation Protocol (12 Months Postoperative) of Total Knee Prostheses Anatomic With Resurfaced Patella Versus Non-resurfaced Patella in Patients Requiring Total Knee Arthroplasty
Total knee arthroplasty is a frequent surgery in France. It currently represents 70,000 interventions per year. The total knee prosthesis is also called tri-compartmental because it allows articulation between the femur and the…
- Trial name
- NCT03081260
- Testing
- Patellar resurfacing, Patellar non-resurfacing
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Total Knee Replacement, Transcutaneous Electrical Nerve Stimulation
The Effects of Transcutaneous Electrical Nerve Stimulation in Patients With Total Knee Replacement
Total Knee Replacement (TDP) is considered the best treatment option available when conservative methods such as anti-inflammatory or physical therapy fail.
- Conditions
- Total Knee Replacement, Transcutaneous Electrical Nerve Stimulation, Total Knee Replacement Surgery
- Trial name
- NCT05115565
- Testing
- TENS (Transcutaneous Electrical Nerve Stimulation) Application
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Bozok University
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Infected Total Hip or Knee Arthroplasty
Assessing Renal Function in Patients With an Antibiotic Laden Spacer
The purpose of this study is to monitor the renal function of patients who have an antibiotic laden spacer in place to treat an infected hip or knee arthroplasty.
- Trial name
- NCT01683734
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Central DuPage Hospital
Osteoarthritis, Knee
Study of Patient Outcomes 5 Years After Partial Knee Replacement
The study seeks to evaluate the condition of patients 5 years after having undergone partial knee replacement for localized osteoarthritis of the knee.
- Trial name
- NCT01620892
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Athens Orthopedic Clinic, P.A.
Surgical Wound, Knee Disease
Standard Dressing Versus Moist Dressing in the Course of the Postoperative Wound in Patients With Knee Prosthesis
The aim of the study is: to evaluate the efficacy of two post-operative dressings in the management of the surgical wounds in patients who received a knee prosthesis
- Trial name
- APOSIT-PTG (NCT04422119)
- Testing
- Multi-Foam dressing, Usual care
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Germans Trias i Pujol Hospital
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Pain
Effects of Continuous Nerve Block vs Single Injection Block With PCA vs PCA on Pain and Function After Knee Replacement
The purpose of this study is to compare the effectiveness of three analgesia techniques on pain relief and functional recovery after knee replacement: continuous femoral nerve block vs single-injection femoral nerve block with…
- Trial name
- PCA (NCT01187537)
- Testing
- Continuous Femoral Nerve Block
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- Tan Tock Seng Hospital
Knee Arthroplasty, Total, Knee Osteoarthritis
Physica TT Tibial Plate Prospective Study
This prospective clinical study aims at evaluating clinical, radiographic, patient-reported outcomes of total knee arthroplasty with Physica TT Tibial Plate over 2 years after surgery, in order to assess the performance and…
- Trial name
- NCT06830603
- Volunteers
- 142 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis of the Knee
Investigation of Specific Protein/Markers in Patients With Osteoarthritis of the Knee Having a Total Knee Replacement
The main purpose of the study is to better understand how specific proteins/markers in blood, urine, synovial fluid (a lubricating fluid secreted by the membrane lining the joints), and joint tissue are involved in osteoarthritis…
- Trial name
- NCT01611441
- Where
- 6 sites in Canada, Sweden
- Volunteers
- 125 people
- Sponsor
- AstraZeneca
Total Knee Replacement, Reliability and Validity
Reliability and Validity of the 2-Minute Step Test in Patients With Knee Arthroplasty
Total knee arthroplasty (TKA) is a cost-effective treatment for end-stage knee osteoarthritis. It has demonstrable benefits such as reducing pain and improving activity and quality of life.
- Trial name
- NCT05064943
- Testing
- 2-minute step test
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Kutahya Health Sciences University
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Knee Arthritis
Knee Arthroplasty Performed With Conventional and Customized Instrumentation
The main purpose of this study is to determine whether the surgical time required for primary total knee arthroplasty is significantly less when performed with Customized Patient Instrumentation (CPI) than with conventional…
- Trial name
- CPI (NCT01124305)
- Testing
- Customized Patient Instrumentation, Traditional Instrumentation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Anderson Orthopaedic Research Institute
Knee Disease
Measurement of the Quality of Life in Patients Operated With a Total Knee Prosthesis (TKA) From the FHK® Range.
As part of Medical Devices CE marking regulatory process, an appropriate post-market clinical follow-up (PMCF) is required. This PMCF study is in the framework of CE mark renew of FHK® total knee prosthesis, it aims to answer…
- Trial name
- NCT04578951
- Testing
- FHK® total knee prosthesis
- Where
- France
- Volunteers
- 50 people
- Sponsor
- FH ORTHO
Osteoarthritis, Knee, Osteo Arthritis Knee
Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed
Efficacy and safety study of resiniferatoxin versus placebo to manage pain in patients with knee osteoarthritis whose TKR surgery is delayed
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Pain Chronic
- Trial name
- NCT04386980
- Testing
- Resiniferatoxin
- Sponsor
- Sorrento Therapeutics, Inc.
Knee Osteoarthritis, Acute Pain
iPACK Block With Dexamethasone For Total Knee Replacement
Comparing the pain control outcomes for patients undergoing total knee arthroplasty (TKA) with either: 1) adductor canal single shot injection plus placebo iPACK injection or 2) adductor canal single shot injection plus…
- Conditions
- Knee Osteoarthritis, Acute Pain, Anesthesia, Local, Regional Anesthesia
- Trial name
- NCT04917055
- Testing
- ropivacaine 0.25% with epinephrine and 6mg dexamethasone, Saline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego