Clinical trials: Patients in ICU
Intensive Care Units, Fecal Microbiota Transplantation
Evaluation of Heterologous Fecal microbiotA Transfer in ICU Patients: a FeasibilitY and SafetY StudY
ICU patient's complications are notably due to multiple infections with high risks of sepsis. Those infections would be worsened by any antibiotic resistance mechanism.
- Trial name
- HAPY3 (NCT03350178)
- Testing
- fecal microbiota transfer
- Where
- 2 sites in France
- Volunteers
- 8 people
- Sponsor
- MaaT Pharma
Critical Illness
Feasibility of Blood Glucose Control With the Space TGC System in Postoperative Cardiac Surgery Patients in the ICU
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 02 (NCT01233271)
- Testing
- Space TGC
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- B. Braun Melsungen AG
Sedation
A Study Evaluating the Efficacy and Safety of HSK3486 for Sedation
This is a multi-center, open-label, randomized, propofol-controlled phase II clinical trial.A total of ICU patients undergoing mechanical ventilation are intended to be enrolled and randomly assigned to HSK3486 group and propofol…
- Trial name
- NCT04147416
- Testing
- HSK3486 0.1-0.2 /0.3 mg / kg group, Propofol 0.5-1.0/1.5 mg/kg group
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Liver Dysfunction, Critical Illness
Hepa Wash Treatment of Patients With Hepatic Dysfunction in Intensive Care Units
Patients with hepatic dysfunction are known to have a high mortality rate. Hepa Wash(R) is a newly developed liver and renal support system that is based on the use of recycled albumin dialysate.
- Trial name
- HEPATICUS-2 (NCT01079104)
- Testing
- Hepa Wash, Standard Medical Therapy
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Hepa Wash GmbH
Chronic Obstructive Pulmonary Disease
Efficacy of Helium/Oxygen Compared to Air/Oxygen in Severe Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of the study is to evaluate the efficacy of Helium/Oxygen (He/O2) 78%/22% compared to a conventional Air/O2 mixture in reducing endotracheal intubation rate and mortality in patients with severe hypercapnic…
- Trial name
- ECHO/ICU (NCT01155310)
- Testing
- Helium/Oxygen 78%/22%, Air/Oxygen
- Where
- 16 sites in Belgium, France and 4 more
- Volunteers
- 446 people
- Sponsor
- Air Liquide Santé International
Comparative Study, REE
Comparative Evaluation of smART+ REE Module to an FDA-cleared Device, for REE Calculation in ICU Patients
A prospective, single-center, comparative evaluation of smART+ REE Module to an FDA-cleared REE Module device, for REE calculation in ICU Patients.
- Conditions
- Comparative Study, REE, Resting Energy Expenditure
- Trial name
- (REE) (NCT07165080)
- Testing
- smART+ REE
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- ART Medical Ltd.
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in the ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- Prodex (NCT00479661)
- Testing
- Dexmedetomidine, Propofol
- Where
- 40 sites in Belgium, Finland and 5 more
- Volunteers
- 500 people
- Sponsor
- Orion Corporation, Orion Pharma
Intensive Care Unit
Study to Evaluate Hemodynamic Effect of Different Loading Doses of Precedex in Post-surgical Intensive Care Unit (ICU) Patients
The objective of this study is to characterize the hemodynamic effects of Precedex (dexmedetomidine (DEX)) during 3 loading-dose paradigms in mechanically ventilated post-surgical subjects in an intensive care setting.
- Trial name
- NCT01169571
- Testing
- Dexmedetomidine
- Where
- 17 sites in Canada
- Volunteers
- 373 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
General Anesthesia
Remimazolam Phase II Cardiac Anesthesia Study
This phase II study in patients undergoing elective cardiac surgery will evaluate the efficacy, safety, and pharmacokinetics of remimazolam, compared with propofol and sevoflurane, during the induction and maintenance of general…
- Trial name
- NCT01937767
- Testing
- Remimazolam, Propofol, Sevoflurane
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Paion UK Ltd.
Critically Ill
Pilot Study on Gastro-intestinal (GI) Enteral Nutrition (EN) Tolerance in Intensive Care Unit Patients
Specifically designed enteral formulations may improve the gastrointestinal tolerance during early enteral nutrition in the critically ill patient.
- Trial name
- SPIRIT (NCT01581957)
- Testing
- Specific Enteral Nutrition, Standard Enteral Nutrition
- Where
- Switzerland
- Volunteers
- 90 people
- Sponsor
- Société des Produits Nestlé (SPN)
Surgical Procedure, Unspecified
VRES Study in Two Phases to Monitor Cardiac Surgical Patients Following Discharge From ICU
Failure to recognise deterioration early is a major cause of preventable deaths amongst hospital patients. The investigators wish to study whether continuous monitoring of 'vital signs' (pulse rate, breathing rate, and blood…
- Trial name
- VRES (NCT02427828)
- Testing
- Visensia Respiration Rate Estimation Service (VRES)
- Where
- United Kingdom
- Volunteers
- 208 people
- Sponsor
- OBS Medical Ltd
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Closed Loop Glucose Control in Patients With Type 1 and Type 2 Diabetes
This is a proof of concept safety study of an artificial intelligence based closed loop glucose control system designed for use in the intensive care unit setting.
- Trial name
- NCT05644730
- Testing
- Fusion closed loop glucose control system
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ideal Medical Technologies
Critically-ill
Safety and Performance of Muscle Activation for Critical Care Patients
Critically-ill patients who have long stays in the hospital often face prolonged periods of bed rest. It is known that these patient develop profound weakness and debilitation.
- Trial name
- NCT01552616
- Testing
- Thermal-aided muscle activation
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Niveus Medical, Inc.
Anemia
A Study to Observe the Causes and Treatment of Anemia in Critically Ill Children
The purpose of this study is to determine the incidence of anemia and blood transfusions and management of these in critically ill children
- Trial name
- NCT00211055
- Volunteers
- 1,201 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Critically Ill, Malnutrition
Promotion of Oesophageal Motility to Prevent Regurgitation and Enhance Nutrition Intake in ICU Patients.
Early enteral feeding is a key component of the management of critically ill patients receiving mechanical ventilation. However, enteral feeding has been associated with serious complications such as gastro-esophageal reflux…
- Trial name
- PROPEL (NCT02515123)
- Testing
- E-Motion System
- Where
- 11 sites in Canada
- Volunteers
- 158 people
- Sponsor
- E-Motion Medical Ltd.
Urine Output, ICU Patients
Evaluation of Male and Female External Catheters for Urine Output Monitoring in the ICU
The goal of this observational pilot study is to learn about the ability of the PureWick® Flex Female External Catheter and the PureWIck® Male External Catheter to capture urine output in adult ICU patients compared to indwelling…
- Trial name
- NCT07744945
- Testing
- Indwelling Urinary Catheter, External Urinary Catheter
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- C. R. Bard
Hypovolemia
Gelatin in ICU and Sepsis
This prospective, double-blind randomized controlled trial evaluates the differences in terms of efficacy and safety of gelatin based resuscitation as compared to crystalloid based resuscitation in two parallel groups of patients…
- Trial name
- GENIUS (NCT02715466)
- Testing
- Balanced gelatine solution, Balanced electrolyte solution
- Where
- 12 sites in Austria, Czechia and 3 more
- Volunteers
- 167 people
- Sponsor
- B. Braun Melsungen AG
Acute Kidney Injury
ProNephro NGAL Test for Early Detection of Acute Kidney Injury in Adult ICU Patients (ALPACA)
The purpose of this study is to evaluate the performance of the ProNephro AKI™ (NGAL) test for identifying critically ill adults at risk of developing moderate to severe acute kidney injury (KDIGO Stage 2/3) within 48 to 72 hours…
- Trial name
- ALPACA (NCT07751913)
- Testing
- ProNephro AKI™ (NGAL)
- Where
- 4 sites in United States
- Volunteers
- 800 people
- Sponsor
- BioPorto Diagnostics
Critical Illness
Usability of Blood Glucose Control With the Space TGC System in Medical ICU Patients
Hyperglycemia is common in critically ill patients and associated with an adverse outcome. Thus, glycaemic control is an important issue in critical care.
- Trial name
- DELIOS 4 (NCT01164449)
- Testing
- Space TGC
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- B. Braun Melsungen AG
Agitation, Delirium
Study of BXCL501 In Agitation Associated With Delirium in ICU Patients
This study is designed to determine and evaluate the optimal BXCL501 starting dose (StartD) that will safely and effectively reduce agitation associated with delirium in ICU patients.
- Trial name
- NCT05313386
- Testing
- BXCL501
- Where
- United States
- Sponsor
- BioXcel Therapeutics Inc