Clinical trials: Patients in ICU
Ventilator Weaning, Intensive Care Unit
Use of Transient Elastogaphy to Assess Diaphragm Function in Mechanically Ventilated Patients
Mechanical ventilation is a life-saving treatment that can be associated with diaphragm dysfunction, a potentially deleterious acquired disability.
- Trial name
- Elasto-ICU (NCT03832231)
- Testing
- Shear Wave Elastography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Shock, Intensive Care
CHangeovers of Norepinephrine in Intensive Care
CHIC study's purpose is to compare the efficiency, in terms of blood pressure stability, of three changeovers of norepinephrine used routinely in ICU. The three techniques are: Quick change Double pumping Smart infusion pumps
- Trial name
- CHIC (NCT02304939)
- Testing
- changeover, use of automatic infusion pump, datas collection
- Where
- France
- Volunteers
- 285 people
- Sponsor
- University Hospital, Angers
Clinical Outcomes
Pattern of Disease and Determinants of Clinical Outcomes Among ICU Patients
The global mortality rate of patients on MV is very high which is varied with the income level of the country, duration of a mechanical ventilator, the pattern of disease, ICU staff profile, availability of medical supplies.
- Trial name
- PDCO (NCT05303831)
- Testing
- Mechanical ventilator
- Where
- Ethiopia
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Dilla University
Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19
Assessment of Sedation Depth Using Processed EEG in ICU Patients With ARDS Receiving Neuromuscular Blockade: A Prospective Observational Study"
"In intensive care units, therapeutic paralysis has been a routine treatment method for many years in a select group of patients.
- Conditions
- Sedation Complication, Acute Respiratory Distress Syndrome Due to COVID-19, Anesthesia Awareness
- Trial name
- NCT06337877
- Testing
- Depth of sedation monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Tepecik Training and Research Hospital
Critical Illness, ARDS
The RIsk Stratification in COVID-19 Patients in the ICU Registry
The Risk stratification in COVID-19 patients in the ICU (RISC-19-ICU) registry was founded during the emerging SARS-CoV-2 pandemic.
- Conditions
- Critical Illness, ARDS, Inflammatory Response, COVID-19
- Trial name
- RISC-19-ICU (NCT04357275)
- Testing
- ICU treatment
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Hyperglycemia
Humalog or Humulin for Intensive Insulin Therapy in Intensive Care Unit
Insulin preparation -random assignment to regular insulin lin or lispro insulin as first treatment- was administered at constant infusion rate (0.04 units/Kg/h) in patients presenting blood glucose concentration ≥180 mg/dl and…
- Trial name
- NCT02165566
- Testing
- Regular-insulin, Lispro-insulin
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- University of Roma La Sapienza
Candidiasis
Early Clinical Experience With Anidulafungin In Patients With Liver Disease In The United Kingdom
The purpose of this study is to describe the real world effectiveness of anidulafungin in clinical practice in a large Liver Unit in the United Kingdom.
- Trial name
- NCT01202253
- Testing
- anidulafungin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Pfizer
Colistin Resistance in Bacteria
Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards.
The increasing use of colistin in multidrug resistant strains, as Enterobacteriaceae producing extended-spectrum β-lactamases or carbapenemases, is associated with the emergence of colistin resistant isolates.
- Trial name
- RESCO (NCT03971877)
- Testing
- Rapid Polymyxin NP test
- Where
- 4 sites in France
- Volunteers
- 1,934 people
- Sponsor
- University Hospital, Bordeaux
Intensive Care Unit, Muscle Strength
Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals
Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients.
- Trial name
- HHD-ICU (NCT06296381)
- Where
- 4 sites in Brazil
- Volunteers
- 180 people
- Sponsor
- University of Pernambuco
ICU Hospitalization, Sleep Deprivation
Impact of Sleep Deprivation on Malnutrition in ICU (Intensive Care Unit) Patients
Study Design This study is a prospective cohort design conducted at Zhongshan Hospital affiliated with Fudan University. It will involve systematic assessments of sleep quality, nutritional status, and associated clinical…
- Conditions
- ICU Hospitalization, Sleep Deprivation, Malnutrition Severe
- Trial name
- NCT07032441
- Testing
- PSG
- Volunteers
- 150 people
- Sponsor
- Shanghai Zhongshan Hospital
Device Ineffective, Safety Issues
The HEALiX™ Intubated Patient (IP) Pilot Study
The current standard of care for limiting the movement of mechanically ventilated critical care patients is the use of physical wrist restraints, which are both ineffective in preventing removal of invasive and adjunct…
- Trial name
- NCT04759066
- Testing
- HEALiX
- Where
- United States
- Sponsor
- Lancaster General Hospital
Asynchronies
Evaluation of an Informative Intervention to the ICU Team About the Presence of Asynchronies in Mechanically Ventilated Patients: Effect Over Incidence Reduction
Mechanical ventilation (MV) if a life-support treatment for critically ill patients that can develop adverse effects. Patient-ventilator asynchronies can be present from the beginning of MV, it can be associated with poor outcome…
- Trial name
- NCT02714751
- Testing
- Daily asynchronies information
- Where
- Spain
- Volunteers
- 166 people
- Sponsor
- Corporacion Parc Tauli
Septic Shock, Sepsis
Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients
The goal of this clinical trial is to assess the effect of targeting upper normal serum magnesium levels on norepinephrine requirements in adult patients with septic shock. The main questions it aims to answer are: 1.
- Trial name
- NCT07716956
- Testing
- magnesium sulfate, standard care treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Platelets/Albumin and Aki
Platelets to Albumin Ratio for Prediction of Acute Kidney Injury in Patients Admitted to the Intensive Care Unit
To evaluate the role of platelet to albumin ratio to detect Acute kidney injury in patients admitted to intensive care
- Trial name
- NCT06554977
- Testing
- Laboratory
- Volunteers
- 140 people
- Sponsor
- Assiut University
Sepsis, Need of Cardiac Surgery
International Registry on the Use of the CytoSorb Adsorber
Registry on the use of the CytoSorb® adsorber in ICU patients.
- Trial name
- CytoSorb (NCT02312024)
- Testing
- Use of CytoSorb adsorber
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,434 people
- Sponsor
- Jena University Hospital
Covid19, Cognitive Impairment
The COGCOV Study in ICU Patients
Acute Respiratory Distress syndrome (ARDS) is a pulmonary systematic inflammatory response, leading to acute respiratory failure with hypoxia and/or hypercarbia.
- Trial name
- COGCOV (NCT04593069)
- Testing
- Neurocognitive assessment
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Ziekenhuis Oost-Limburg
Arterial Line, Consent of Patients
Hemodynamic and Biological Evaluations During Reventilation Collapse in ICU
Prospective, observational clinical multicentric study in ICU; during the period surrounding the orotracheal intubation.
- Conditions
- Arterial Line, Consent of Patients, Adult Patients, Tracheal Intubation in ICU
- Trial name
- REVECOL (NCT01785654)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postoperative Nausea and Vomiting
Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting
To evaluate the effectiveness of a prophylactic dose of ondansetron in decreasing the incidence of post-operative nausea and vomiting in cardiac surgery patients after cessation of post-operative sedation.
- Trial name
- NCT02966041
- Testing
- Ondansetron, Saline
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- University of British Columbia
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Osteoarticular Infection, Intensive Care Patients
OsteoArticular Sepsis in Intensive Care unitS
This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses).
- Conditions
- Osteoarticular Infection, Intensive Care Patients, Prosthetic Joint Infection
- Trial name
- OASIS (NCT06627842)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris