Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
A Non-interventional Study Evaluating Clinical Utility and Implications on Improved Patient Management of Serum Neurofilament as a Prognostic Marker for Disease Activity in Patients With Relapsing Multiple Sclerosis
This is a prospective, multicenter, observational, non-interventional study (NIS) in patients with Multiple Sclerosis (MS) and routinely assessed serum neurofilament light (sNfL) values in Germany
- Trial name
- FILAXOS (NCT06551519)
- Testing
- ofatumumab, DMT category 1
- Where
- 82 sites in Germany
- Volunteers
- 519 people
- Sponsor
- Novartis Pharmaceuticals
Relapsing Multiple Sclerosis
To Evaluate the Safety and Efficacy of Teriflunomide in Patients With Relapsing Forms of Multiple Sclerosis
Primary Objective: To describe the safety of teriflunomide in patients with relapsing forms of multiple sclerosis. Secondary Objective: To describe the efficacy of teriflunomide in patients with relapsing forms of multiple…
- Trial name
- SAFE (NCT03856619)
- Testing
- TERIFLUNOMIDE HMR1726
- Where
- 14 sites in India
- Volunteers
- 121 people
- Sponsor
- Sanofi
Multiple Sclerosis (MS)
A Study on the Safety and Tolerability of Universal STAR-T Cell Therapy for Multiple Sclerosis.
This is a Phase I, single-arm, open-label, dose-escalation and dose-expansion study. The main objective is to explore the safety and tolerability of the universal STAR-T cell injection in patients with progressive or…
- Trial name
- NCT07523100
- Testing
- Universal STAR-T Cell Injection
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Daishi Tian
Multiple Sclerosis
Clinical Investigation of the Quality of Life Benefit of Using a Home Walking Exoskeleton for a Population of Multiple Sclerosis Patients.
The goal of this clinical investigation is to evaluate the effectiveness of home use of a lightweight robotic lower limb exoskeleton as a walking aid device on quality of life in patients with multiple sclerosis with gait…
- Trial name
- EXHOMESEP (NCT05835622)
- Testing
- Keeogo, adviced home practice
- Where
- 6 sites in France
- Volunteers
- 28 people
- Sponsor
- Pôle Saint Hélier
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Relapsing-Remitting Multiple Sclerosis (RRMS)
Efficacy and Safety of the Biosimilar Natalizumab PB006 in Comparison to Tysabri®
This is a multi-center, randomized, parallel arm, double-blind study with a total duration of subjects' participation of 48 weeks.
- Trial name
- Antelope (NCT04115488)
- Testing
- Intravenous (IV) infusions
- Where
- 48 sites in Belarus, Croatia and 5 more
- Volunteers
- 265 people
- Sponsor
- Polpharma Biologics S.A.
Urinary Bladder, Neurogenic, Multiple Sclerosis
Botulinum Toxin A vs Anticholinergic Treatment of Neurogenic Overactive Bladder in Patients With Multiple Sclerosis
Botulinum toxin type A injections into the detrusor at a dose of 200 units (U) of BOTOX® are a recognized second-line treatment for the treatment of adult neurogenic lower urinary tract disorders.
- Trial name
- SEPTOX (NCT04819360)
- Testing
- VESIcare 10Mg Tablet, Botox 100 UNT Injection
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Brigitte Schürch
Multiple Sclerosis (MS)
Next-Gen MS: Feed-forward PRO Data for MS Research
This Next Generation learning health system for Multiple Sclerosis (Next-Gen MS) study is a sub-study of the MS-LINK™ Outcomes Study (NCT04735406).
- Trial name
- NCT04907305
- Where
- 8 sites in United States
- Volunteers
- 1,594 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Multiple Sclerosis
Motor Evoked Potentials With Modified Facilitation Technique
Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in…
- Trial name
- EP-F (NCT03646929)
- Testing
- MEP using standard facilitation technique, MEP using modified facilitation technique
- Where
- Switzerland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Systemic Sclerosis
A Study of KHK4827 in Patients With Systemic Sclerosis
Exploratory evaluation of pharmacokinetics and safety of KHK4827 in subjects with systemic sclerosis
- Trial name
- NCT04368403
- Testing
- KHK4827
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Multiple Sclerosis
Muscle Vibration and Fatigue in Patients With MS
Multiple Sclerosis is the most common cause of neurologic chronic disability in young adults. Fatigue is one of the principal symptom in this disease.
- Trial name
- NCT05783999
- Testing
- vibra plus
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
The Reliability, Validity, and Responsiveness of the Static Balance Test in Patients With Multiple Sclerosis.
The aim of the study is to investigate reliability, validity, and responsiveness of the Static Balance Test in patients with Multiple Sclerosis.
- Trial name
- NCT03584672
- Testing
- Static Balance Test, Berg Balance Scale, Timed Up an Go Test
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Relapsing-Remitting Multiple Sclerosis
An fMRI Study of Treatment Optimization Comparing Two Disease Modifying Therapies Used to Treat Relapsing Remitting Multiple Sclerosis
Impaired short term memory, attention and concentration lapses, and slower processing of information occur in up to 40-65% of patients with Multiple Sclerosis (MS).
- Trial name
- NCT00398528
- Testing
- Glatiramer acetate, (Copaxone®), IFN-β-1a, (Avonex®)
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Neurognostics
Parkinson, Multiple Sclerosis
Driving Performance in Parkinson's Disease and Multiple Sclerosis Using a Driving Simulator
This prospective observational study investigates whether driving performance measured in a standardized driving simulator differs between people with Parkinson's disease, people with multiple sclerosis, and healthy drivers.
- Trial name
- NeuroSimDrive (NCT07809828)
- Testing
- Standardized Driving Simulator Assessment
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Pendular Nystagmus Patients With Multiple Sclerosis
Treatment of Pendular Nystagmus With Gabapentin and Memantine in Patients With Multiple Sclerosis
Different treatment trials have been published in acquired nystagmus in the last decade; gabapentin and memantine have been found to be efficient in treating pendular nystagmus in Multiple Sclerosis.
- Trial name
- NCT01744444
- Testing
- Memantine, Gabapentin
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis
Open-Label Extension Study to Evaluate the Safety, Tolerability and Activity of Oral Fampridine-SR in Patients With Multiple Sclerosis Who Participated in the MS-F204 Trial
The purpose of the study is to evaluate the safety, tolerability and activity of Fampridine-SR when administered for up to 36 additional months in patients who previously participated in the MS-F204 study or until it becomes…
- Trial name
- NCT00649792
- Testing
- Fampridine-SR
- Where
- 42 sites in United States, Canada
- Volunteers
- 214 people
- Sponsor
- Acorda Therapeutics
Multiple Sclerosis
Impact of a Tele-rehabilitation Program on People With Multiple Sclerosis
The goal of this clinical trial is to assessing safety and the occurrence of adverse effects during tele-rehabilitation (TRHB) in people with multiple sclerosis with an EDSS score of 6.5 or lower.
- Trial name
- Telerehab (NCT07178834)
- Testing
- Telerehab
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Multiple Sclerosis Center of Catalonia
Multiple Sclerosis
Post Marketing Surveillance Study to Evaluate the Tolerability of Rebif® New Formulation in Patients With Relapsing Multiple Sclerosis in an Australian Clinical Setting.
This observational multicentric study is planned to assess the tolerability of Rebif New Formulation in an Australian clinical setting by the incidence of injection site reactions (ISRs).
- Trial name
- ReNew (NCT01101776)
- Testing
- Interferon beta-1a (Rebif)
- Where
- 16 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Relapsing Remitting Multiple Sclerosis
Phase 3 Study to Evaluate Efficacy and Safety of NU100 in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)
The purpose of this study is to evaluate the safety and efficacy of NU100 in patients with relapsing remitting multiple sclerosis (RRMS) as compared to placebo and an active comparator.
- Trial name
- NCT01464905
- Testing
- NU100, rhIFN beta-1b
- Where
- 12 sites in Belarus, Bulgaria and 10 more
- Volunteers
- 500 people
- Sponsor
- Nuron Biotech Inc.
Relapsing Remitting Multiple Sclerosis
A Study for Patients With Relapsing Remitting Multiple Sclerosis
The purpose of this study is to test if dirucotide is safe and effective in treating patients with relapsing remitting multiple sclerosis.
- Trial name
- MINDSET01 (NCT00869986)
- Testing
- dirucotide
- Where
- 6 sites in Bulgaria, Poland and 4 more
- Volunteers
- 218 people
- Sponsor
- Eli Lilly and Company