Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
Prospective, Multicenter Non Interventional Study to Evaluate Adherence to Betaferon Over a 2 Years Period
The aim of the SEPLUS study is to evaluate the patients characteristics associated with adherence to Betaferon over a 24-month follow up period after the initiation of Betaferon in the BetaPlus program
- Trial name
- SEPLUS (NCT01076595)
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Bayer
Multiple Sclerosis
Effectiveness of Dry Needling for Improving Gait in the Patient With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease characterized by the appearance of lesions, characterized by heterogeneity in its pathological, clinical and radiological presentation.
- Trial name
- DRYNEEDEM (NCT05956119)
- Testing
- dry needling + physiotherapy (standard/usual care)
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Universitario de Canarias
Physical Therapy, Upper Extremity Function
Upper Extremity Function, Shoulder Position Sense and Disability Level İn Patients With Multiple Sclerosis
The purposes of this study is to investigate the relationship between upper extremity muscle function and shoulder position sense in patients with Multiple Sclerosis (MS) and which best projects the disability status.
- Conditions
- Physical Therapy, Upper Extremity Function, Position Sense
- Trial name
- NCT03846336
- Testing
- Upper extremity function, Shoulder position sense
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Multiple Sclerosis
An Investigation of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Sclerosis Patients
A study to compare the efficacy of GW-1000-02 [named Sativex® in Canada and also named Sativex® Oromucosal Spray] with placebo in relieving five key symptoms of Multiple Sclerosis after six weeks of therapy.
- Trial name
- NCT01610700
- Testing
- GW-1000-02
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Jazz Pharmaceuticals
Relapsing-remitting Multiple Sclerosis
A Study to Compare Efficacy, Pharmacokinetics, Pharmacodynamics and Safety of CT-P53 and Ocrevus in Patients With Relapsing-remitting Multiple Sclerosis
This is a double-blind, randomized, active-controlled, parallel group, Phase 1/3 study to compare efficacy, PK, PD and overall safety of CT-P53 with Ocrevus in patients with Relapsing-remitting Multiple Sclerosis.
- Trial name
- NCT05906992
- Testing
- CT-P53, US-Ocrevus, EU-Ocrevus
- Where
- Poland
- Volunteers
- 512 people
- Sponsor
- Celltrion
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive
Clinnova-MS: A Prospective Cohort Study of Patients With Multiple Sclerosis: A Trans-regional Digital Health Effort Unlocking the Potential of Artificial Intelligence and Data Science in Health Care
The Clinnova-Multiple Sclerosis (MS) study is part of the Clinnova program (NCT06526364; NCT06235684 and NCT05733702), which seeks to advance precision medicine and the digitalization of healthcare through high-quality…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Chronic Progressive, Clinically Isolated Syndrome, Primary Progressive Multiple Sclerosis
- Trial name
- Clinnova-MS (NCT07280871)
- Testing
- Cohort
- Where
- Luxembourg
- Volunteers
- 100 people
- Sponsor
- Luxembourg Institute of Health
Muscle Spasticity
Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Associated With Multiple Sclerosis
A drug called AV650 (tolperisone HCl) will be given to patients who have spasticity associated with multiple sclerosis. This study has three purposes: 1. To determine whether AV650 is safe for patients with multiple sclerosis; 2.
- Trial name
- NCT00532532
- Testing
- tolperisone HCl
- Where
- 28 sites in Czechia, Germany and 3 more
- Volunteers
- 150 people
- Sponsor
- Avigen
Multiple Sclerosis
Validation of the French Adaptation of the MSWDQ-23 Questionnaire
MS is an autoimmune disease of the central nervous system that affects more than 120,000 people in France. The average age of onset of the disease is between 25 and 35 years.
- Trial name
- WORKSEP (NCT04860791)
- Testing
- questionnaires
- Where
- 16 sites in France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
A Serologic Study to Correlate Beta-IFN NAb Titers to Beta-IFN Induced Biomarker Response in Patients With Multiple Sclerosis
Study Title: A Serologic Study to Correlate b-IFN NAb titers to b-IFN Induced Biomarker Response in Patients with Multiple Sclerosis Objectives: Subjects currently on any of the three b-IFN preparations (Avonex (Interferon b-1a…
- Trial name
- NCT00288990
- Where
- 28 sites in United States
- Volunteers
- 300 people
- Sponsor
- Biogen
Multiple Sclerosis, Relapsing-Remitting
A Phase IIIb, Multicenter, International Study to Evaluate the Efficacy, Safety and Tolerability of EK-12 in Patients With RRMS
Multiple sclerosis is a chronic autoimmune, inflammatory neurological disease of the central nervous system. It is the most common disabling neurologic disease of young people.
- Trial name
- NCT03283397
- Testing
- EK-12, INF beta-1a
- Where
- Turkey (Türkiye)
- Volunteers
- 301 people
- Sponsor
- Bosnalijek D.D
Multiple Sclerosis
VR-treadmill Combined Intervention for Enhancing Mobility and Cognitive Function in Patients With Multiple Sclerosis
A prospective, randomized controlled single-blind trial will test the hypotheses that a 6- week intervention that combines treadmill training (TT) with virtual reality (VR) significantly improves real-life, functional mobility…
- Trial name
- NCT02427997
- Testing
- Treadmill training with Virtual Reality, Treadmill training
- Where
- 2 sites in United States, Israel
- Volunteers
- 139 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Relapsing Multiple Sclerosis
Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patients
This study will assess tolerability and safety and health outcomes in relapsing MS patients taking FTY720.
- Trial name
- NCT01127750
- Testing
- FTY720
- Where
- 289 sites in Australia, Austria and 21 more
- Volunteers
- 2,417 people
- Sponsor
- Novartis
Multiple Sclerosis
The Wearing-off Phenomenon of Ocrelizumab in Patients With Multiple Sclerosis
The primary goal of this research is to study the prevalence of the wearing-off effect and possible risk factors for wearing-off symptoms in patients with multiple sclerosis using ocrelizumab with the use of questionnaires.
- Trial name
- WOC (NCT04478591)
- Testing
- Questionnaires
- Where
- Netherlands
- Volunteers
- 117 people
- Sponsor
- Amsterdam UMC, location VUmc
Multiple Sclerosis, Radiologically Isolated Syndrome
Epstein Barr Virus Infection in Patients With Radiologically Isolated Syndrome
The clinical course of RRMS patients is variable. Among RIS-Consortium international cohorts, one third of RIS patients progressed to MS at 5 years and 52.2% at 10 years.
- Conditions
- Multiple Sclerosis, Radiologically Isolated Syndrome, Epstein-Barr Virus
- Trial name
- EBV-RIS (NCT05815108)
- Testing
- NO INTERVENTION
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Multiple Sclerosis
Jacobson's Progressive Muscle Relaxation for Fatigue and Kinesiophobia in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic neurological condition that can cause fatigue and fear of movement (kinesiophobia), which may interfere with daily activities and participation in rehabilitation.
- Trial name
- JPMRT (NCT07854691)
- Testing
- Jacobson's Progressive Muscle Relaxation Technique (JPMRT), Routine Care
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Al-Zaytoonah University of Jordan
Multiple Sclerosis, Cognitive Decline
MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients With Multiple Sclerosis
This clinical study aims to identify MS related beneficial plasticity and by contrast maladaptive reorganization in combination with elements of daily functional status as a response to a cognitive training program
- Trial name
- MSNEUROPLAST (NCT04806568)
- Testing
- Cognitive Training, Monitoring of daily activity
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Multiple Sclerosis
Efficacy of Anti-Tubercular Vaccination in Multiple Sclerosis
The frequency of auto-immune diseases (including multiple sclerosis) is increasing in industrialised countries. According to an hypothesis which is receiving a wide international credit, this may be due to the fact that the…
- Trial name
- NCT00202410
- Testing
- Bacille of Calmette-Guerin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- S. Andrea Hospital
Multiple Sclerosis
The Effects of Action Observation Therapy (AOT) on Balance and Gait in Patients With Multiple Sclerosis.
Action observation therapy is a new method in rehabilitation that causes motor retraining by activating mirror neurons while watching the activity on the screen and then practicing them.
- Trial name
- NCT05543213
- Testing
- Action Observation Therapy
- Where
- Iran
- Volunteers
- 28 people
- Sponsor
- Shiraz University of Medical Sciences
Multiple Sclerosis, Cognitive Impairment
Neurocognitive Changes in Patients With Remitting Relapsing Multiple Sclerosis Treated With Natalizumab
Cognitive impairment is seen in about half of patients with relapsing remitting MS. Our knowledge about long term development of cognitive performance under natalizumab therapy is limited.
- Trial name
- NCT01250678
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Relapsing Remitting Multiple Sclerosis
Flupirtine as Oral Treatment in Multiple Sclerosis
Flupirtine, a non-opioid analgesic drug, that has been shown to have additional neuroprotective functions, is given twice daily as an oral medication in patients with relapsing remitting multiple sclerosis over a period of 12…
- Trial name
- FLORIMS (NCT00623415)
- Testing
- Flupirtine
- Where
- 4 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
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