Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
Immunotherapy With BHT-3009 Alone or Combined With Atorvastatin in Patients With Multiple Sclerosis
This research study is being done to evaluate the safety of BHT-3009 alone and when combined with atorvastatin (Lipitor) in patients with multiple sclerosis (MS).
- Trial name
- NCT00103974
- Testing
- BHT-3009-01
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- Bayhill Therapeutics
Amyotrophic Lateral Sclerosis
Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZYIL1 in Patients With Amyotrophic Lateral Sclerosis
ZYIL1 is expected to show benefit in patients with Amyotrophic Lateral Sclerosis (ALS). The present study aims to determine the safety, tolerability, pharmacokinetics, and pharmacodynamics of ZYIL1 when administered to subjects…
- Trial name
- NCT05981040
- Testing
- ZYIL1 capsules 25 mg and ZYIL1 capsules 50 mg
- Where
- 7 sites in India
- Volunteers
- 24 people
- Sponsor
- Zydus Lifesciences Limited
Multiple Sclerosis
A Phase 1/2a Study of Oral PRO-1562 in Healthy Subjects and Patients With Relapsing Multiple Sclerosis
Phase 1 will test single oral doses of PRO-1562 in healthy adult subjects to characterize the safety and the amount of drug that is absorbed into the body.
- Trial name
- NCT07826689
- Testing
- PRO-1562 Oral Capsules
- Where
- Australia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Progentos Therapeutics
Rehabilitation, Multiple Sclerosis
Virtual Reality Approach in Multiple Sclerosis
The aim of our study is to investigate the effects of game-based virtual reality exercise added to conventional physiotherapy and rehabilitation program in patients with Multiple Sclerosis (MS).
- Trial name
- NCT04212689
- Testing
- Game Based Virtual Reality Exercises, Conventional Physiotherapy and Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Secondary Progressive Multiple Sclerosis
A Study for Patients With Secondary Progressive Multiple Sclerosis
The purpose of this study is to determine whether MBP8298 is effective and safe in the treatment secondary progressive multiple sclerosis. Dirucotide is generic name for MBP8298.
- Trial name
- MAESTRO-01 (NCT00869726)
- Testing
- dirucotide
- Where
- 10 sites in Canada, Denmark and 8 more
- Volunteers
- 596 people
- Sponsor
- Eli Lilly and Company
Relapsing-remitting Multiple Sclerosis
Sensori-motor Integration Training in Multiple Sclerosis
Balance impairment is a common and very disabling disturbance in people with Multiple Sclerosis. The efficacy of pharmacotherapy in treating balance impairment in MS is poorly documented in literature.
- Trial name
- NCT01040117
- Testing
- Sensory-motor Integration Training, Conventional neurorehabilitation treatment
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
Multiple Sclerosis, Covid19
Estimating Prevalence of COVID-19 Infection and SARS-CoV-2 Antibodies in MS Patients
This non-interventional, biospecimen collection study is designed to help us better understand whether MS patients have impaired immune defenses to COVID-19 infection.
- Trial name
- NCT04682548
- Where
- United States
- Volunteers
- 920 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis
A Trial to Compare the Effectiveness of Two Rehabilitation Programs for Multiple Sclerosis Patients
The purpose of this study was to compare the effectiveness of two rehabilitation programs (one month) in patients with multiple sclerosis.
- Trial name
- REHABMUSCLE (NCT01871818)
- Testing
- Combined program, Physiotherapy in private practice
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Relapsing Remitting Multiple Sclerosis
Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis
This study consisted of a two year dose blinded phase during which patients received one of five doses of siponimod (10, 2, 1.25, 0.5 or 0.25mg) following which patients were switched to open label treatment with siponimod 2mg…
- Trial name
- NCT01185821
- Testing
- BAF312
- Where
- 46 sites in United States, Canada and 10 more
- Volunteers
- 185 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Memory Rehabilitation Strategies in Patients With Multiple Sclerosis
The clinical characteristics of MS are extremely variable from one patient to another. In about 60% of cases, motor disabilities are associated with cognitive deficits.
- Trial name
- NCT05462678
- Testing
- Cognitive Rehabilitation, Combined Rehabilitation, Motor Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Multiple Sclerosis, Endocrine System Diseases
Trabecular Bone Score in Multiple Sclerosis
Assess bone quality in MS patients through TBS and evaluate the potential effects exerted by different drugs used in MS treatment, which may affect BMD and TBS in MS patients
- Conditions
- Multiple Sclerosis, Endocrine System Diseases, Neurologic Disorder
- Trial name
- NCT05811689
- Testing
- sm tbs group
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Multiple Sclerosis
Memantine Therapy for Multiple Sclerosis
To assess the efficacy of Memantine in improving the cognitive impairment in patients with Multiple Sclerosis (MS)
- Trial name
- Memantine-MS (NCT00638833)
- Testing
- Memantine
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Multiple Sclerosis
Dual-Task Performance in Patients With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. It is reported that 85% of patients with multiple sclerosis have gait disturbance, 88% balance, and 35-90% fatigue (1, 2, 3).
- Trial name
- NCT03508284
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gazi University
Multiple Sclerosis
Caregiver Burden in Caregivers of Patients With Multiple Sclerosis
Individuals aged 18-80 years who have been clinically diagnosed with multiple sclerosis and their caregivers will be included in the study.
- Trial name
- NCT07549048
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Relapsing Multiple Sclerosis (RMS)
Study of Efficacy and Safety of Fingolimod (Gilenya) 0.5 mg in Chinese Patients With Relapsing Multiple Sclerosis (RMS) Patients
The main purpose of this study was to assess the efficacy and safety of 0.5mg Fingolimod (Gilenya) in Chinese patients with relapsing multiple sclerosis (RMS)
- Trial name
- NCT04667949
- Testing
- Fingolimod 0.5mg
- Where
- 13 sites in China
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Relapsing Remitting Multiple Sclerosis
A Phase 2 Study of Orelabrutinib in Patients With Relapsing-Remitting Multiple Sclerosis
This is a randomized, double-Blind, placebo-controlled Phase 2 Study of Orelabrutinib in Patients with Relapsing-Remitting Multiple Sclerosis.
- Trial name
- NCT04711148
- Testing
- orelabrutinib
- Where
- 42 sites in United States, China and 2 more
- Volunteers
- 160 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Multiple Sclerosis
Alexithymia Frequency and Interhemispheric Transfer in Patients With a First Demyelinating Event
Prevalence of alexithymia in multiple sclerosis (MS) is closed to 50% but is unknown in clinically isolated syndrome (CIS).The present study sought to characterize alexithymia in CIS patients and his link between psycho…
- Trial name
- ALEXCIS (NCT03796247)
- Where
- France
- Volunteers
- 57 people
- Sponsor
- University Hospital, Lille
Multiple Sclerosis
Current Exercise Approaches in Patients With Multiple Sclerosis
This study was conducted to examine the effects of exercises performed with mechanical hippotherapy device and Cawthorne-Cooksey exercises on balance, dizziness, fatigue and quality of life in patients with Multiple Sclerosis.
- Trial name
- NCT06005909
- Testing
- Cawthorne-Cooksey Exercises, Mechanical Hippotherapy Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Uskudar University
Multiple Sclerosis
Characteristic Study on Chinese Patients With Multiple Sclerosis
Compared with MS in white populations, in people of China descent multiple sclerosis (MS)is characterized by lower prevalence, more frequent and severe involvement of the visual system at onset and during the entire clinical…
- Trial name
- NCT00818103
- Testing
- atorvastatin, β-interferon, EPO
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Sun Yat-sen University
Multiple Sclerosis, Radiologically Isolated Syndrome
Diagnostic Value of eVOG
Eye movement is a complex neurological function controlled by many structures located in the central nervous system. The eyeball is mobile within the orbit and its movements are carried out using 6 muscles innervated by 3…
- Conditions
- Multiple Sclerosis, Radiologically Isolated Syndrome, White Matter Lesions
- Trial name
- DIVEyes (NCT05776511)
- Testing
- eVOG
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
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