Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
Aerobic Fitness in Multiple Sclerosis: The Relationship Between Balance and Sensory Dual-Tasking
The aim of this study is to comparatively examine the effect of aerobic fitness levels on walking and balance performance, sensory dual-task (proprioceptive and vestibular) performance, balance confidence, and fatigue levels in…
- Trial name
- NCT07815990
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Suleyman Demirel University
Multiple Sclerosis
Trial to Assess the Safety and Feasibility of Adoptive Cell Therapy with Autologous EBV-specific Cytotoxic T Lymphocytes (CTL) in Patients with a First Clinical Episode Highly Suggestive of Multiple Sclerosis
The etiologic mechanisms involved in multiple sclerosis (MS) are not yet fully understood. Indeed MS is a multifactorial disease involving genetic and environmental factors and Epstein-Barr-Virus (EBV) could be one of these…
- Trial name
- MS and EBV-CTL (NCT02912897)
- Testing
- Cellular therapy with EBV specific autologous CTL infusion
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Nantes University Hospital
Multiple Sclerosis, Insomnia
Digital Cognitive-behavioral Therapy for Insomnia for Patients With Multiple Sclerosis
The goal of this clinical trialis to compare a digital Cognitive-behavioral intervention for insomnia to digital administered applied relaxation in participants with Multiple Sclerosis.
- Trial name
- NCT06025968
- Testing
- i-CBT, Applied relaxation
- Where
- Sweden
- Volunteers
- 69 people
- Sponsor
- Uppsala University
Multiple Sclerosis, Apraxia
Occupational Therapy in Patients With Multiple Sclerosis
Limb apraxia is defined as the inability to correctly perform skilled and/or learned limb movements, which cannot be explained by elementary motor and sensory deficits or cognitive problems.
- Trial name
- NCT01507636
- Testing
- Occupational Therapy, Physical therapy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Progressive Multiple Sclerosis, Fatigue
A Study of Oxidative Pathways in MS Fatigue
This is a 4-week randomized, placebo-controlled, parallel group, double-blind, single center trial on effect of N-acetyl cysteine versus placebo on fatigue in patients with progressive MS defined by McDonald criteria.
- Trial name
- NCT02804594
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
Comparison of the Performance of an Optimized 3D EPI SWI Sequence and a Non-EPI QSM SWI Sequence in Detecting the Central Vein Sign in Patients With Multiple Sclerosis
Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which four additional 20-minute sequences will be added.
- Trial name
- COPEQ-MS (NCT04705870)
- Testing
- cerebral MRI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Spasticity, Multiple Sclerosis, Stroke, Trauma
Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity
Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors…
- Trial name
- ANTMS (NCT01786005)
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Multiple Sclerosis (MS) - Relapsing-remitting
Treating Multiple Sclerosis With Sirolimus, an Immune System Suppressor
The purpose of this study is to determine the safety and tolerability of the drug sirolimus in patients with multiple sclerosis (MS) who have failed other treatments.
- Trial name
- NCT00095329
- Testing
- sirolimus
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting
This national, open-label study is designed to give complementary efficacy, safety and patient reported outcomes (PROs) data in participants with active relapsing forms of MS.
- Trial name
- PRO-MSACTIVE (NCT03589105)
- Testing
- Ocrelizumab 300 mg, Ocrelizumab 600 mg
- Where
- 46 sites in France
- Volunteers
- 423 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis
Long Term Safety of Teriflunomide When Added to Interferon-Beta or Glatiramer Acetate in Patients With Multiple Sclerosis
The primary objective was to evaluate the long-term safety and tolerability of teriflunomide when added to treatment with interferon-β [IFN-β] or glatiramer Acetate [GA] in patients with multiple sclerosis [MS] with relapses.
- Trial name
- NCT00811395
- Testing
- Teriflunomide, Interferon-β [IFN-β], Glatiramer Acetate [GA]
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 182 people
- Sponsor
- Sanofi
Multiple Sclerosis, Telerehabilitation
The Effects of Respiratory-based Telerehabilitaion in Patients With MS
During the pandemic, it is important for people who are isolated in their homes to stay inactive and exercise exercises in order to prevent their complaints from increasing due to inactivity.
- Conditions
- Multiple Sclerosis, Telerehabilitation, Compliance, Patient
- Trial name
- MS (NCT04887051)
- Testing
- pulmonory based home exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dr. Anıl Tosun
Relapsing-Remitting Multiple Sclerosis
Combination Therapy (Provigil + Avonex) to Treat Cognitive Problems in MS
MS has been associated with fatigue, attention problems, and a number of cognitive difficulties. There is no treatment approved yet to treat these problems.
- Trial name
- NCT00210301
- Testing
- Provigil (modafinil)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Institute for Clinical Research
Multiple Sclerosis
Development and Evaluation of the Self-management Module in Patients With Multiple Sclerosis
Compared with other chronic disease states, MS patients feel more uncertainty and less control over illness and non-illness aspects of life, and as a result, they have poor self-management abilities.
- Trial name
- NCT05209113
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Hacettepe University
Multiple Sclerosis, Urinary Bladder, Neurogenic
Urinary Disorders in Patients With Multiple Sclerosis: Invasive Vs Non-invasive Investigations.
The objective of the study is to describe the current status of MS patients with urinary disorders in Lebanon, and to demonstrate whether invasive investigations improve the management of these patients compared to an optimal…
- Conditions
- Multiple Sclerosis, Urinary Bladder, Neurogenic, Urodynamics
- Trial name
- NCT03336424
- Testing
- Non-invasive investigations, Invasive investigations
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Saint-Joseph University
Clinically Isolated Syndrome (CIS), Multiple Sclerosis (MS)
Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases
This a retrospective, blinded trial in which collaborators in Italy will review the doppler findings from the Combined Transcranial and Extracranial Venous Doppler (CTEVD) trial in an attempt to measure reproducibility.
- Conditions
- Clinically Isolated Syndrome (CIS), Multiple Sclerosis (MS), Other Neurological Disorders (OND), Healthy (HC)
- Trial name
- NCT02308579
- Volunteers
- 499 people
- Sponsor
- University at Buffalo
Multiple Sclerosis
Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project
The purpose of this study is to assess and compare how well multiple sclerosis (MS) patients tolerate cetirizine versus diphenhydramine as a pre-medication before receiving anti-CD20 infusion therapy of ocrelizumab, ublituximab…
- Trial name
- NCT07472413
- Testing
- Cetirizine, Diphenhydramine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Multiple Sclerosis
The Effect of Task-Oriented Training in Patients With Multiple Sclerosis
It is reported that 85% of MS patients have gait disturbance, 87.9% balance, 35-90% fatigue and 45-60% cognitive problems. Rehabilitation approaches based on the motor control systems model, the plasticity concept, the motor…
- Trial name
- NCT03505294
- Testing
- Task-oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
Multiple Sclerosis
Effects of Mat and Reformer Pilates in Multiple Sclerosis
Our study aims to investigate the effects of core stability-based Mat Pilates and Equipment-Based Pilates training on anticipatory postural adjustments (APA), balance, and gait in individuals with Multiple Sclerosis (MS).
- Trial name
- NCT06931522
- Testing
- Mat Pilates, Reformer Pilates
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Relapsing-Remitting Multiple Sclerosis
Safety and Effectiveness of Generic Fingolimod (Sphingomod®, Hikma) in Patients With Relapsing-Remitting Multiple Sclerosis in Egypt
The purpose of this observational study is to evaluate the Safety and Effectiveness of Generic Fingolimod (Sphingomod®, Hikma) in Patients with Relapsing-Remitting Multiple Sclerosis in Egypt
- Trial name
- NCT05423769
- Testing
- Fingolimod
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Hikma Pharmaceuticals LLC
Physical Therapy
Core Stability, Trunk Position Sense, Balance and Functional Mobility in Patients With Multiple Sclerosis
The aim of this study is to compare balance, functional mobility, core stability and trunk position sense in patients with Multiple Sclerosis (PwMS) and healthy controls and investigate the relationship between core stability and…
- Trial name
- NCT03566251
- Testing
- Balance, Functional mobility, Core stability
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
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