Clinical trials: Patients with Multiple Sclerosis
Multiple Sclerosis
A Safety and Efficacy Study of CNTO1275 in Patients With Multiple Sclerosis
The purpose of the study is to evaluate the effectiveness and safety of CNTO 1275 in patients with Multiple Sclerosis
- Trial name
- NCT00207727
- Testing
- CNTO 1275
- Volunteers
- 249 people
- Sponsor
- Centocor, Inc.
Relapsing Remitting Multiple Sclerosis (RRMS)
ELIOS - Investigational Biomarkers to Track Disease Modification in Active RRMS
The exploratory ELIOS study aims to assess the value of novel investigational Eye Movement Biomarkers (EMBs) in tracking disease-related changes among a real-world cohort of Canadian patients with active RRMS, within the context…
- Trial name
- ELIOS (NCT06733922)
- Testing
- ETNATM-ProgMS
- Where
- 14 sites in Canada
- Volunteers
- 224 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis, Osteoarthritis
FolateScan in Autoimmune Disease
This study will gather information on the safety of FolateScan and the ability of FolateScan to detect inflammation in the joints and other organs in people with arthritis (rheumatoid arthritis and osteoarthritis), systemic lupus…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Multiple Sclerosis, Crohn's Disease
- Trial name
- NCT00588393
- Testing
- FolateScan (Technetium Tc 99mEC20)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Multiple Sclerosis
Hematopoietic Stem Cell Therapy for Patients With Multiple Sclerosis
Multiple sclerosis is disease believed to be due to immune cells, cells which normally protect the body, but are now attacking the tissue in the brain and possibly the spinal cord.
- Trial name
- NCT00278655
- Testing
- Hematopoietic stem cell transplantation
- Volunteers
- 21 people
- Sponsor
- Northwestern University
Relapsing Remitting Multiple Sclerosis
Observational Study in Patients With Relapsing-Remitting Multiple Sclerosis Switched to Bafiertam® From Dimethyl Fumarate
This is an open-label, multicenter, observational study evaluating GI symptoms in relapsing-remitting multiple sclerosis (RRMS) patients who switch from dimethyl fumarate (DMF) to Bafiertam®.
- Trial name
- PERSIST (NCT04925778)
- Testing
- monomethyl fumarate
- Sponsor
- Banner Life Sciences LLC
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
Phase II Clinical Trial of OCH-NCNP1
This study is designed to assess the efficacy and safety of OCH-NCNP1 compared to placebo in subjects diagnosed with relapsing remitting multiple sclerosis (RRMS) and secondary progressive mltiple sclerosis (SPMS) .
- Trial name
- NCT04211740
- Testing
- OCH-NCNP1
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- National Center of Neurology and Psychiatry, Japan
Multiple Sclerosis, Relapsing-Remitting
Effects of Task-oriented Training on Functional Mobility and Fatigue in Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is inflammatory, demyelinating and autoimmune disease of the central nervous system. It is usually seen with relapses and genetic and environmental factors play a role in the etiology.
- Trial name
- NCT03497468
- Testing
- Combined exercise training, Task-oriented training
- Volunteers
- 34 people
- Sponsor
- Bezmialem Vakif University
Relapsing Remitting Multiple Sclerosis
Administration of Fingolimod in Greek Patients With Multiple Sclerosis.
The goal of this observational study is to evaluate the efficacy of fingolimod through the estimation of the annualized relapse rate (ARR) over a period of 2 years.
- Trial name
- FILYRA (NCT06949956)
- Volunteers
- 140 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
MULTIPLE SCLEROSIS
The Effects of Interferon Beta Combined With Vitamin D on Relapsing Remitting Multiple Sclerosis Patients
The investigators hypothesize that vitamin D supplementation may ameliorate interferon beta-induced flu-like symptoms, owing to reduced release and activity of the cytokines that are in correlation with this adverse event.
- Trial name
- NCT01005095
- Testing
- Vitamin D3
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Carmel Medical Center
Multiple Sclerosis
Factors That Influence Compliance With Disease-Modifying Therapy in Multiple Sclerosis
The purpose of this study is to evaluate the coorelation between patient factors, health care provider factors, drug factors and compliance in patients with relapsing forms of multiple sclerosis (RMS) treated with Disease…
- Trial name
- NCT00223457
- Testing
- Factors that influence compliance
- Where
- United States
- Volunteers
- 1,040 people
- Sponsor
- University of Texas Southwestern Medical Center
Multiple Sclerosis, Stroke
Telerehabilitation Upper Extremity for Neurological Disorders
The aims of the present study were to: Investigate the feasibility of using a therapeutic gaming system (REHAB@HOME), based on Kinect, to augment upper extremity neurorehabilitation services.
- Trial name
- Telerehab (NCT02764372)
- Testing
- Serious games, Exergames
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Multimodal Exploration of Patients With Multiple Sclerosis for an Early Detection of Subtle Progression
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS), characterized by a complex interplay of inflammatory demyelination and neuronal damage.
- Trial name
- NCT05941975
- Testing
- Visual Evoked Potential (VEP), Somatosensory evoked potential (SSEP), Transcranial magnetic motor evoked potentials (TCmMEP)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Brugmann University Hospital
Neurogenic Overactive Bladder, Multiple Sclerosis
Enhancing Pelvic Floor Function With Transcranial Magnetic and Tibial Nerve Stimulation for Neurogenic Bladder in MS
Multiple Sclerosis (MS) is a chronic, autoimmune, inflammatory, and degenerative neurological disorder that affects the central nervous system.
- Trial name
- NCT06581341
- Testing
- Repetitive Transcranial Magnetic Stimulation and Percutaneous Tibial Nerve Stimulation, Repetitive Transcranial Magnetic Stimulation, Percutaneous Tibial Nerve Stimulation
- Volunteers
- 60 people
- Sponsor
- Sierra Varona SL
Multiple Sclerosis
EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis
Spasticity is a frequent and debilitating symptom in patients with multiple sclerosis (MS). It can alter the patients' balance, mobility, as well as their quality of life.
- Trial name
- EXOSEP (NCT06702137)
- Testing
- EXOPULSE MOLLII SUIT (active)
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences
Multiple Sclerosis (MS)
Physical Capacity and Rehabilitation of Patients With Multiple Sclerosis
The purpose of this study is to assess the physical capacity of patients with multiple sclerosis and the effects of rehabilitation, encompassing physical therapy and physical activity as it is carried out in the day hospital of…
- Trial name
- REHABSEP (NCT02352194)
- Testing
- Rehabilitation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ehlers-Danlos Syndrome, Multiple Sclerosis
Vascular Fundus Changes in Patients With High Probability of Chronic Cerebrospinal Venous Insufficiency (CCSVI)
The investigators propose that evidence of chronic cerebrospinal venous insufficiency (CCSVI) may be evident in the vasculature of the fundus.
- Trial name
- NCT01356134
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Genetic Disease Investigators
Multiple Sclerosis
Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis
This study will determine whether magnetic resonance imaging (MRI) can detect damage to certain parts of the brain and analyze the thickness of the brain's outer surface in patients with multiple sclerosis.
- Trial name
- NCT00099307
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Relapsing Multiple Sclerosis, Clinically Isolated Syndrome
A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis
This was a multicenter, non-interventional, retrospective study aiming to evaluate the real-world effectiveness and safety of siponimod treatment in Chinese patients with relapsing forms of multiple sclerosis (RMS).
- Conditions
- Relapsing Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
- Trial name
- NCT06395909
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Novartis
Multiple Sclerosis
Study to Evaluate the Feasibility of [18F]Florbetapir PET for Assessment in MS Patients
The purpose of this study is to evaluate the feasibility of [18F]Florbetapir positron emission tomography (PET) for assessment of demyelination in the patients with relapsing remitting multiple sclerosis.
- Trial name
- NCT01767493
- Testing
- [18F]Florbetapir PET imaging
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Autoimmune Diseases, Inflammatory Disease
In Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases
Interleukin 2 (IL-2) is a critical cytokine for the survival and function of regulatory T cells (LTreg). This cytokine has a dual role in the immune system.
- Conditions
- Autoimmune Diseases, Inflammatory Disease, Acquired Bone Marrow Aplasia, Systemic Lupus Erythematosus
- Trial name
- MuTreg (NCT05544448)
- Testing
- Blood sample taken at a single time point
- Where
- France
- Volunteers
- 67 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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