Clinical trials: Patients with Multiple Sclerosis
Relapsing Multiple Sclerosis
A Study of Ocrelizumab in Comparison With Interferon Beta-1a (Rebif) in Participants With Relapsing Multiple Sclerosis
This randomized, double-blind, double-dummy, parallel-group study will evaluate the efficacy and safety of ocrelizumab in comparison with interferon beta-1a (Rebif) in participants with relapsing multiple sclerosis.
- Trial name
- NCT01247324
- Testing
- Interferon beta-1a, Ocrelizumab
- Where
- 142 sites in United States, Argentina and 30 more
- Volunteers
- 821 people
- Sponsor
- Hoffmann-La Roche
MULTIPL SCLEROSİS
Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers
Multiple Sclerosis (MS) is a chronic immune-mediated and neurodegenerative disease of the central nervous system that often affects young adults and is more common in women.
- Trial name
- NCT07521982
- Where
- Turkey (Türkiye)
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- Baskent University
Multiple Sclerosis, Muscle Spasticity
Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
This study is being conducted to compare the impact of somnolence (sleepiness) on cognition (awareness) as well as the safety and effectiveness of tizanidine hydrochloride capsules versus Zanaflex® (tizanidine hydrochloride…
- Conditions
- Multiple Sclerosis, Muscle Spasticity, Spinal Cord Injury, Stroke
- Trial name
- NCT00047580
- Testing
- tizanidine hydrochloride capsule
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Elan Pharmaceuticals
Multiple Sclerosis
A Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Participant Satisfaction in Participants With Multiple Sclerosis (MS)
The main purpose of the study is to evaluate participant satisfaction after administration of ocrelizumab subcutaneously (SC) after 12 months using the therapy administration satisfaction questionnaire subcutaneous (TASQ-SC).
- Trial name
- SurfSubQ (NCT06780150)
- Testing
- Ocrelizumab
- Where
- 93 sites in Germany, Switzerland
- Volunteers
- 842 people
- Sponsor
- Hoffmann-La Roche
Pendular Nystagmus, Oculopalatal Tremor
Treatment of Pendular Nystagmus in OPT
Pendular nystagmus corresponds to an enduring to and fro eye oscillation without resetting quick phases. The most common causes of acquired pendular nystagmus (APN) are multiple sclerosis (MS) and focal brainstem lesions…
- Trial name
- NCT02466191
- Testing
- Memantine, Gabapentin
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Hospices Civils de Lyon
Multiple Sclerosis, Relapsing-Remitting
Post-Authorization Observational Study to Evaluate Cognition and Fatigue in Relapsing-remitting Multiple Sclerosis (RRMS) Patients Treated With Rebif®
The study is planned to evaluate the cognitive functions in subjects with RRMS treated with interferon beta-1a, and its relationship to the fatigue and neurological dysfunction status.
- Trial name
- SKORE (NCT01075880)
- Testing
- Rebif (Interferon beta-1a)
- Where
- 13 sites in Czechia
- Volunteers
- 300 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Multiple Sclerosis
Retrospective Study on Registry Data to Evaluate the Impact of Ocrelizumab Used in Routine Care in Patients With RRMS
Multiple Sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease; clinical events are mainly attributed to myelin destruction and inflammatory of the central nervous system.
- Trial name
- SEP-RR (NCT04838015)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Sclerosis, Relapsing-Remitting
Fingolimod -Response According to Coping - Evaluation
This is a prospective, open-label, multi-center phase IV study to assess response to fingolimod initiation according to coping profile in adult patients with highly active relapsing remitting multiple sclerosis in France.
- Trial name
- GRACE (NCT01420055)
- Testing
- fingolimod
- Where
- 47 sites in France
- Volunteers
- 189 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Eye Movements Recording Using a Smartphone: Comparison to Standard Video-oculography in Patients With Multiple Sclerosis
This study aims to compare measurements obtained through the e-VOG application (mobile application, usable on mobile phones or tablets, to measure eye movements) with measurements from the standard video-oculography device…
- Trial name
- NCT04702763
- Testing
- Eye-Tracker®T2 + e-VOG, e-VOG + Eye-Tracker®T2
- Where
- Monaco
- Volunteers
- 30 people
- Sponsor
- Association de Recherche Bibliographique pour les Neurosciences
Multiple Sclerosis
Safety of Avonex Treatment in Multiple Sclerosis Patients With Neutralizing Antibodies to Interferon Beta Therapy
This study is to find out the safety and effectiveness of Avonex (interferon-beta-1a) Therapy in patients who have developed neutralizing antibodies during previous interferon-beta treatment
- Trial name
- SAFE (NCT00493077)
- Testing
- low immunogenic interferon-beta-1a
- Where
- 5 sites in Sweden
- Volunteers
- 3 people
- Sponsor
- Biogen
Multiple Sclerosis
Evaluation of Interoception, Fatigue, and Upper and Lower Extremity Functional Capacity in Multiple Sclerosis Patients With Good and Poor Sleep Quality
Multiple sclerosis (MS) is a chronic disease of the central nervous system associated with a wide range of motor and non-motor symptoms.
- Trial name
- NCT07374237
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Gulhane School of Medicine
Fatigue, Multiple Sclerosis
Acupuncture or MBSR for Patients With Fatigue and MS
The main aim of this trial is to evaluate whether additional acupuncture or mindfulness-based stress reduction is more efficacious than usual care only to reduce fatigue in patients with multiple sclerosis.
- Trial name
- MS-Fatigue (NCT01864707)
- Testing
- Usual care + acupuncture, usual care+mbsr, usual care
- Where
- Germany
- Volunteers
- 104 people
- Sponsor
- Charite University, Berlin, Germany
Multiple Sclerosis
Safety of Bryostatin in Patients With MS
This is a single-site, single-arm, single-dose, Phase 1 study of the safety of bryostatin in participants with multiple sclerosis (MS) receiving any disease modifying therapy (DMT).
- Trial name
- NCT06190912
- Testing
- Bryostatin 1
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Robert Fox
Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis
PET with [18F]Flumazenil As an Index of Neurodegeneration in MS
Beyond white matter pathology, grey matter damage is considered as a key player in disability onset and progression in Multiple Sclerosis (MS).
- Trial name
- FLUMA-SEP-T (NCT03825601)
- Testing
- PET with [11C]Flumazenil
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Multiple Sclerosis
The Effect of Backward Walking Training on Balance, Gait and Functional Mobility in Patients With Multiple Sclerosis
Backward walking training can be a useful treatment approach, providing novel balance and gait challenges. It can lead to improve balance, gait and functional mobility in neurologic populations.
- Trial name
- NCT05505383
- Testing
- Exercise training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Saglik Bilimleri Universitesi
Multiple Sclerosis
Investigation of the Effects of Technology Supported Different Physiotherapy Approaches on Patients With Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, demyelination and axonal loss of the central nervous system.
- Trial name
- NCT04891341
- Testing
- Technology Supported Task-Oriented Circuit Training, Home-based Telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Hacettepe University
Amyotrophic Lateral Sclerosis (ALS)
Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to determine whether nine months of administration of creatine monohydrate results in an increase in muscle strength in patients with amyotrophic lateral sclerosis (ALS).
- Trial name
- NCT00069186
- Testing
- Creatine Monohydrate
- Where
- 8 sites in United States
- Volunteers
- 107 people
- Sponsor
- The Avicena Group
Systemic Sclerosis, Scleroderma
Efficacy and Tolerability of STI571 (Imatinib Mesylate) for the Treatment of Fibrosis in Participants With Systemic Sclerosis
This study investigates the efficacy and safety of STI571 for the treatment of fibrosis in participants with systemic sclerosis.
- Trial name
- NCT00613171
- Testing
- STI571
- Where
- 7 sites in United States, Germany and 3 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis
Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri
The primary objective of the study is to evaluate the safety of natalizumab use in the pediatric multiple sclerosis (MS) population.
- Trial name
- NCT02137109
- Testing
- natalizumab
- Volunteers
- 400 people
- Sponsor
- Biogen
Relapsing-remitting Multiple Sclerosis, Clinically Isolated Syndrome
Safety/Effectiveness of Adding Monthly Dexamethasone to Weekly Avonex for MS
The purpose of the study is to determine whether giving intravenous dexamethasone every 4 weeks during the first 12 months of weekly Avonex dosing will reduce the progression of functional impairment, brain atrophy, relapse rate…
- Trial name
- NCT00232193
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Providence Multiple Sclerosis Center
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