Clinical trials: Pediatric Cancers
Cancer, Pediatric Cancer
Education Tools to Support Pediatric Survivor Care
This study aims to evaluate the impact of electronic educational materials on adolescent and young adult (AYA) survivors' knowledge about late effects, perceived benefits, self-efficacy, and intentions to engage in lifelong…
- Trial name
- NCT04257058
- Testing
- Electronic educational material
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Emory University
Pediatric ALL, Child, Hospitalized
Robot Rehab: AAI With Robot During Inpatient Pediatric Rehab
The purpose of this study is to: Aim 1: Evaluate the feasibility [consent and refusal rates, attrition rates, length, and number of completed therapy sessions], and acceptability [interviews with children and guardians, overall…
- Conditions
- Pediatric ALL, Child, Hospitalized, Physical Therapy Modalities, Occupational Therapy
- Trial name
- NCT05275543
- Testing
- Paro Robot
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Nebraska
Pediatric Cancer, CNS Tumor, Childhood
Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy
This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.
- Conditions
- Pediatric Cancer, CNS Tumor, Childhood, Skin Inflammation
- Trial name
- NCT04479514
- Testing
- Warm Baths or Showers, Moisturizer, SPF 30 or Higher Suncreen
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Dana-Farber Cancer Institute
Heart Failure, Cardiotoxicity
The HIMALAYAS Trial and Lifestyle Changes in Pediatric, Adolescent and Young Adult Cancer Survivors Study: A Multicentre Randomized Controlled Trial
Pediatric, adolescent and young adult cancer survivors (PAYA-CS) are at higher risk of cardiovascular (CV) morbidity and mortality.
- Conditions
- Heart Failure, Cardiotoxicity, Cancer
- Trial name
- HIMALAYAS (NCT05023785)
- Testing
- Cardio-oncology Rehabilitation (CORE)
- Where
- Canada
- Volunteers
- 336 people
- Sponsor
- University Health Network, Toronto
Hematopoietic System--Cancer
Exercise and Health Counseling in Pediatric Hematopoietic Stem Cell Transplantation
Thanks to medical advances, survival rates >5 years in children/adolescents undergoing hematopoietic stem cell transplant (HSCT) exceed 70%.
- Trial name
- Henkō (NCT06300515)
- Testing
- Control Group (Active Comparator), Intervention Group
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Alejandro Lucia
Leukemia, Lymphoma
Assessing Arsenic Trioxide in Young Patients With Leukemia or Lymphoma Who Were Treated on Clinical Trial NCI-00-C-0070J
RATIONALE: Studying bone marrow and blood samples from patients with leukemia or lymphoma treated with arsenic trioxide may help doctors learn more about cancer.
- Trial name
- NCT00899015
- Testing
- pharmacological study
- Volunteers
- 23 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pediatric ALL, Stone, Urinary
Indications and Outcomes in Kidney-ureteral Pediatric Lithiasis: Experience of Parma
Incidence of paediatric urolithiasis is increasing in Europe and North America. Nowadays the management of stone disease is a common practice in not endemic country.
- Trial name
- NCT04605315
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
Cancer-related Problem/Condition
Description of Individual Radiosensitivity With Molecular Biomarkers in a Pediatric Oncology Population
This study aims to explore prospectively the distribution of individual radiosensitivity in the pediatric population and to determine the predictive power of individual radiosensitivity biomarkers from an immunofluorescence…
- Trial name
- ARPEGE BioM (NCT02827552)
- Testing
- skin biopsy
- Where
- 11 sites in France
- Volunteers
- 40 people
- Sponsor
- Institut de Cancérologie de Lorraine
Leukemia Acute Lymphoid Leukemia (ALL), Lifestyle Intervention for at Least 1 Month
The Effect of Child-centered Empowerment on Lifestyle of Leukemia Patients
This randomized clinical trial aimed to evaluate the effectiveness of a child-centered empowerment model in improving the lifestyle of children with leukemia.
- Trial name
- lifestyle (NCT07162558)
- Testing
- Child-Centered Empowerment Intervention
- Where
- Cyprus
- Volunteers
- 46 people
- Sponsor
- Near East University, Turkey
Chemotherapy Induced Nausea and Vomiting
Safety and Pharmacokinetics of Sancuso and IV Granisetron in Patients Aged 2 to 5 Years
The purpose of this study is to determine the dosing strategy for adolescents aged 2 to 5 years.
- Trial name
- NCT01596426
- Testing
- Sancuso, IV granisetron
- Sponsor
- Kyowa Kirin Pharmaceutical Development Ltd
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Non-Hodgkin Lymphoma
Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well samotolisib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with TSC or PI3K/MTOR mutations that have spread to other places in the…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Non-Hodgkin Lymphoma, Malignant Glioma
- Trial name
- NCT03213678
- Testing
- Biospecimen Collection, Computed Tomography, FDG-Positron Emission Tomography
- Where
- 127 sites in United States, Puerto Rico
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Children With Cancer
Art-Based Emotion Regulation Program
Adolescents receiving cancer treatment often experience increased anxiety, difficulties in emotion regulation, and a high symptom burden due to treatment-related physical effects and psychosocial stressors.
- Trial name
- NCT07367035
- Testing
- Art-Based Emotion Regulation Program
- Volunteers
- 60 people
- Sponsor
- Gazi University
Retinoblastoma, Clear Cell Sarcoma
Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors
This is a Phase I trial with new experimental drugs such as simvastatin in combination with topotecan and cyclophosphamide in the hopes of finding a drug that may work against tumors that have come back or that have not responded…
- Conditions
- Retinoblastoma, Clear Cell Sarcoma, Renal Cell Carcinoma, Rhabdoid Tumor
- Trial name
- AflacST1402 (NCT02390843)
- Testing
- Simvastatin, Cyclophosphamide, Topotecan
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Emory University
Sarcoma
Late Effects of Treatment for Sarcomas in Children
This study will examine late effects of treatment for sarcoma (bone and soft tissue cancers) in children. Survival of patients with these diseases has improved over the years, but long-term adverse effects of treatment have also…
- Trial name
- NCT00006515
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Physical Inactivity
Dyadic Physical Activity Intervention for Children Undergoing Cancer Treatment
The goal of this study is to learn if a parent-child dyadic physical activity (PA) intervention works to improve physical activity levels in children with leukaemia.
- Trial name
- DYAD-PA (NCT07737418)
- Testing
- Dyadic Physical Activity Intervention, Individual Intervention, Psychological Support
- Volunteers
- 198 people
- Sponsor
- The Hong Kong Polytechnic University
Cardiopulmonary Arrest, Pediatric ALL
Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness
This study will be a prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary pediatric physicians and nurses.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- InterFACE (NCT04464603)
- Testing
- InterFACE (mHealth tool), Conventional methods
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Oral Mucositis, Pediatric Cancer
Curcumin VS Photo-bio-modulation Therapy of Oral Mucositis in Pediatric Patients Undergoing Anti-Cancer Non-invasive Treatment
The main objective of this study is to assess the impact of non-invasive photodynamic therapy by Curcumin and photo-bio-modulation low level (LL) laser treatment in managing mucositis induced by chemotherapy in pediatric…
- Trial name
- NCT06044142
- Testing
- Curcumin, Laser
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Riyadh Elm University
Compare Two Nutrition Screening Tools
Pilot Test for a Newly Developed Nutrition Screening Method: Pediatric Subjective Global Assessment
Researchers are studying ways to predict if cancer patients are at risk for poor nutrition during their chemotherapy treatment. They hope to identify children with nutrition problems early in treatment.
- Trial name
- NCT00665691
- Testing
- Nutritional Screening Tools
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- St. Jude Children's Research Hospital
Thyroid Carcinoma, Pediatric Cancer
Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy
This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer.
- Trial name
- NCT07473518
- Where
- 2 sites in Italy
- Volunteers
- 2,550 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Adamantinous Craniopharyngioma, Recurrent Adamantinomatous Craniopharyngioma
MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma
MEKTOVI (binimetinib) is an oral, highly selective reversible inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2.
- Trial name
- NCT05286788
- Testing
- Binimetinib Oral Tablet [Mektovi]
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 38 people
- Sponsor
- Nationwide Children's Hospital
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